公开(公告)号：US20240176047A1

公开(公告)日：2024-05-30

申请号：US18436094

申请日：2024-02-08

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/00 ,  B05D5/10 ,  B29D11/00 ,  B29K83/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20230158760A1

公开(公告)日：2023-05-25

申请号：US17991174

申请日：2022-11-21

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06

CPC classification number: B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06 ,  G02B1/10 ,  G02B1/18 ,  G02B1/043 ,  G02C7/049 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  G02C2202/06 ,  G02C2202/16

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a watersoluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20200172756A1

公开(公告)日：2020-06-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.

公开(公告)号：US20240288713A1

公开(公告)日：2024-08-29

申请号：US18588279

申请日：2024-02-27

Applicant: Alcon Inc.

Inventor： Ethan Leveillee ,  Joseph Michael Lindacher ,  David Borja ,  Ying Pi ,  Newton T. Samuel ,  Ya-Wen Chang

IPC: G02C7/04 ,  B29D11/00 ,  G02C7/02 ,  B29K29/00

CPC classification number: G02C7/049 ,  B29D11/00057 ,  B29D11/00317 ,  B29D11/0048 ,  G02C7/021 ,  B29C2795/007 ,  B29K2029/04

Abstract: An embedded contact lens that comprises a lens body that has an anterior surface and an opposite posterior surface. The lens body is composed of a bulk hydrogel material and a circular insert embedded in the bulk hydrogel material and comprises an annular mask on the anterior surface or the posterior surface of the lens body. The circular insert comprises a peripheral edge. Both the annular mask and the insert are concentric with a central axis of the lens body. The annular mask is an opaque colored area that covers or overlaps the peripheral edge of the circular insert to minimize or eliminate optical disturbances induced by peripheral edge of the circular insert.

公开(公告)号：US11933941B2

公开(公告)日：2024-03-19

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D5/00 ,  B29D11/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/10 ,  B29K83/00

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109 ,  G02B1/043 ,  C08L83/04

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20230357478A1

公开(公告)日：2023-11-09

申请号：US18313489

申请日：2023-05-08

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Cornelius Daniel Niculas ,  Richard Charles Breitkopf ,  Nicholas Gober ,  Chandana Kolluru ,  Zahra Bassampour ,  Steve Yun Zhang

IPC: C08F283/12

CPC classification number: C08F283/124

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: depositing a small drop of a viscous lens-forming composition in the center of a female lens mold half; placing a preformed insert on top of the small drop precisely in the center of the female lens mold half so that the insert is held by capillary forces due to the presence of a thin layer of the viscous lens-forming composition between the insert and the molding surface of the female lens mold half; dosing an amount of another less viscous lens-forming composition on top of the insert to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; curing both the lens-forming compositions in the molding assembly to form an embedded hydrogel lens precursor.

公开(公告)号：US11648583B2

公开(公告)日：2023-05-16

申请号：US16843989

申请日：2020-04-09

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Yongxing Qiu ,  John Dallas Pruitt ,  Matthew McCollum

IPC: B05D1/18 ,  G02B1/18 ,  C09D5/00 ,  C09D133/02 ,  B05D3/02 ,  B05D3/10 ,  G02C7/04

CPC classification number: B05D1/18 ,  B05D3/0209 ,  B05D3/107 ,  C09D5/002 ,  C09D133/02 ,  G02B1/18 ,  B05D2258/00 ,  B05D2401/20 ,  B05D2401/21 ,  B05D2502/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing, in a consistent manner, contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material having azetidinium groups onto a base coating of a polyanionic polymer on a contact lens at a relatively low temperature (e.g., from about 40° C. to about 60° C.). The coating temperature for forming a durable hydrogel coating on top of the base coating of a contact lens can be significantly lowered by raising, in situ, the pH (to about 9.5 or higher) of a reactive coating solution which contains the hydrophilic polymeric material having azetidinium groups.

公开(公告)号：US11534994B2

公开(公告)日：2022-12-27

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: B29D11/00 ,  G02B1/18 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.