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公开(公告)号：US11952449B2
公开(公告)日：2024-04-09
申请号：US17148197
申请日：2021-01-13
Applicant: Alcon Inc.
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
IPC: C08F226/06 , C08F220/56 , C08F220/58 , C08G73/06 , C08L33/26 , C08L79/02 , C09D5/02 , C09D133/14 , C09D133/26 , C09D179/02 , C09D179/08 , G02B1/04 , C08F220/28 , C08F220/38
CPC classification number: C08F220/56 , C08L33/26 , C08L79/02 , C09D5/02 , C09D133/14 , C09D133/26 , C09D179/02 , C09D179/08 , G02B1/043 , C08F220/283 , C08F220/286 , C08F220/382 , C08F220/58 , C08F226/06 , C08F2800/10 , C08F2810/20 , C08G73/06 , C08F220/56 , C08F220/54 , C08F220/285 , C08F220/56 , C08F220/54 , C08F220/286 , C08F220/56 , C08F220/54 , C08F220/382 , C08F220/56 , C08F220/54 , C08F220/387 , C08L33/26 , C08L79/02 , C08L33/26 , C08L79/04
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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公开(公告)号：US20220380509A1
公开(公告)日：2022-12-01
申请号：US17870329
申请日：2022-07-21
Applicant: Alcon Inc.
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , G02B1/04 , C08G77/20 , C08G77/16 , C08G77/392
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20220251302A1
公开(公告)日：2022-08-11
申请号：US17666601
申请日：2022-02-08
Applicant: Alcon Inc.
Inventor： Frank Chang , Troy Vernon Holland , Houliang Tang , Adam K. Sniady
Abstract: The invention provides a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. Each of the hydrophilized polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane segment comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one organic substituent having a phosphorylcholine moiety; (2) ethylenically-unsaturated groups. The invention also provides a silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a hydrophilized contact lens from a polymerizable composition comprising at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers.
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公开(公告)号：US20210130644A1
公开(公告)日：2021-05-06
申请号：US17148197
申请日：2021-01-13
Applicant: Alcon Inc.
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
IPC: C09D133/26 , C08L33/26 , C08L79/02 , C09D179/02 , C08F220/28 , C08F220/38 , C08F220/56 , C09D5/02 , C09D133/14 , C09D179/08 , G02B1/04
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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公开(公告)号：US10906258B2
公开(公告)日：2021-02-02
申请号：US16114528
申请日：2018-08-28
Applicant: Alcon Inc.
Inventor： Troy Vernon Holland , Frank Chang , Ryan DeSousa
IPC: B29D11/00 , C08F16/06 , G02B1/04 , B29K105/24 , B29K105/00 , B29K29/00
Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.
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Patent Agency Ranking
公开(公告)号：US20210011197A1
公开(公告)日：2021-01-14
申请号：US17038266
申请日：2020-09-30
Applicant: Alcon Inc.
Inventor： Daqing Wu , Junhao Ge , Steve Yun Zhang , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20210009743A1
公开(公告)日：2021-01-14
申请号：US17038349
申请日：2020-09-30
Applicant: Alcon Inc.
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , G02B1/04 , C08G77/20 , C08G77/16 , C08G77/392
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US12286501B2
公开(公告)日：2025-04-29
申请号：US18435562
申请日：2024-02-07
Applicant: Alcon Inc.
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08L101/14 , C08F290/06 , C08G77/16 , C08G77/20 , C08G77/392 , C08L83/04 , G02B1/04 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20250059330A1
公开(公告)日：2025-02-20
申请号：US18929889
申请日：2024-10-29
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , B29D11/00 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/04 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US12162987B2
公开(公告)日：2024-12-10
申请号：US18465610
申请日：2023-09-12
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , B29D11/00 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/04 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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