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公开(公告)号：US08865148B2
公开(公告)日：2014-10-21
申请号：US14149533
申请日：2014-01-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , C08L77/12 , A61K9/08 , A61K31/337 , A61K47/48 , A61K31/4745 , A61K47/34 , A61K9/10 , A61K9/00
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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12.发明申请公开(公告)号：US20140154300A1
公开(公告)日：2014-06-05
申请号：US14175933
申请日：2014-02-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny
IPC: A61K33/00 , A61K31/198 , A61K38/44 , A61K9/00 , A61K38/00
CPC classification number: A61K33/00 , A61K9/00 , A61K31/198 , A61K38/005 , A61K38/44 , A61L27/38 , A61L29/16 , A61L31/16 , A61L2300/40
Abstract: Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
Abstract translation: 本文公开了在身体损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其它合适的装置之类的递送系统实现递送。
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公开(公告)号：US20140046254A1
公开(公告)日：2014-02-13
申请号：US14054797
申请日：2013-10-15
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy , Zhang Liangxuan , Ed Berger , Stephen Pacetti , John L. Toner
CPC classification number: A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
Abstract: A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
Abstract translation: 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。
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公开(公告)号：US20190133798A1
公开(公告)日：2019-05-09
申请号：US15807963
申请日：2017-11-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Victoria M. Gong , Stephen Pacetti
Abstract: A medical device includes a balloon expanded scaffold crimped to a balloon catheter. The scaffold has a network of rings formed by struts connected at crowns and links connecting adjacent rings. The scaffold has a polymer coating and is crimped to the balloon. The scaffold is rotated, or allowed to rotate during crimping to improve results from crimping, such as reduced damage to the coating.
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公开(公告)号：US09907682B2
公开(公告)日：2018-03-06
申请号：US15356930
申请日：2016-11-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
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Patent Agency Ranking
公开(公告)号：US09795780B2
公开(公告)日：2017-10-24
申请号：US14574684
申请日：2014-12-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Benny Serna , Stephen Pacetti , John Stankus
IPC: A61N1/05 , A61N1/36 , A61N7/00 , A61M25/10 , A61B18/08 , A61B18/14 , A61B18/00 , A61B18/02 , A61B18/04
CPC classification number: A61N1/0551 , A61B18/08 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/0212 , A61B2018/0262 , A61B2018/044 , A61B2018/1435 , A61M25/10184 , A61M25/1029 , A61N1/36117 , A61N7/00 , A61N2007/0021 , A61N2007/0026 , A61N2007/003
Abstract: An apparatus for vascular denervation, comprising a catheter configured for delivery into a vessel of a patient. A balloon is mounted on a distal tip of the catheter, the balloon being configured to be inflatable and further configured so that, upon inflation, the balloon adopts a shape that includes a first edge and a second edge that wind around each other in a double helix, the first edge and the second edge being separated from each other by a first crease and a second crease that also wind around each other in a double helix. A first electrode is attached to the balloon and is located to extend along the first edge.
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公开(公告)号：US09669137B2
公开(公告)日：2017-06-06
申请号：US14613304
申请日：2015-02-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Fuh-Wei Tang , Xiao Ma , Ni Ding , Derek Mortisen
IPC: A61F2/82 , A61K47/48 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/91 , A61L2/08 , B29C71/04 , C08G63/08 , B29B13/08 , B29C35/08 , A61F2/91
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
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公开(公告)号：US20160052200A1
公开(公告)日：2016-02-25
申请号：US14928823
申请日：2015-10-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yung-Ming Chen , Jason Van Sciver , Syed F.A. Hossainy , Stephen Pacetti
CPC classification number: B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
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公开(公告)号：US20150352264A1
公开(公告)日：2015-12-10
申请号：US14298144
申请日：2014-06-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Julia C. Fox , Joel Harrington , Stephen Pacetti
CPC classification number: A61L31/14 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , A61L31/18 , C08L53/02
Abstract: This invention is directed to vascular stents that can be visualized in vivo through the use of fluorescent imaging.
Abstract translation: 本发明涉及通过使用荧光成像在体内可视化的血管支架。
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20.发明授权Controlling moisture in and plasticization of bioresorbable polymer for melt processing 有权控制生物可吸收聚合物的水分和塑化，用于熔体加工公开(公告)号：US09168677B2
公开(公告)日：2015-10-27
申请号：US14311175
申请日：2014-06-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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