公开(公告)号：US20140046254A1

公开(公告)日：2014-02-13

申请号：US14054797

申请日：2013-10-15

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Zhang Liangxuan ,  Ed Berger ,  Stephen Pacetti ,  John L. Toner

IPC: A61L29/16 ,  A61L29/08

CPC classification number: A61L29/16 ,  A61L29/08 ,  A61L29/085 ,  A61L29/141 ,  A61L2300/416 ,  A61L2300/606

Abstract: A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.

Abstract translation: 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。