公开(公告)号：US20090124547A1

公开(公告)日：2009-05-14

申请号：US12116886

申请日：2008-05-07

Applicant: Robert R. Webb ,  Constance A. McKee

Inventor： Robert R. Webb ,  Constance A. McKee

IPC: A61K38/18 ,  C07K14/475 ,  A61P25/00

CPC classification number: A61K47/6807 ,  A61K47/6425 ,  Y10T436/21

Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where:B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell;TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; andL is a linker coupling B to TM.

Abstract translation: 用于将非细胞毒性治疗部分递送至神经细胞的化合物，具有以下通式的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> BL-TM < line-formula description =“In-line Formulas”end =“tail”？>其中：B是能够选择性地结合神经细胞表面受体并介导神经细胞吸收化合物的结合剂; TM是当被神经细胞吸收时具有非细胞毒性治疗作用的治疗部分; L是连接B到TM的接头。

公开(公告)号：US07521198B1

公开(公告)日：2009-04-21

申请号：US10445320

申请日：2003-05-27

Applicant: Nancy R. Webb ,  Frederick C. DeBeer

Inventor： Nancy R. Webb ,  Frederick C. DeBeer

IPC: G01N33/573

CPC classification number: G01N33/6893 ,  G01N33/5088 ,  G01N2800/323 ,  Y10S435/96

Abstract: Methods for detecting atherosclerotic plaque and quantifying the amount of Group V sPLA2 in plasma are disclosed. These methods can be used to assess the risk of cardiovascular pathology in a patient.

Abstract translation: 公开了用于检测动脉粥样硬化斑块和量化血浆中V群SPPLA2量的方法。 这些方法可用于评估患者心血管病变的风险。

公开(公告)号：US20090069229A1

公开(公告)日：2009-03-12

申请号：US11962924

申请日：2007-12-21

Applicant: Kelley A. Smith ,  Steven R. Webb ,  Steven L. Evans ,  Charles A. Mihaliak ,  Donald J. Merlo ,  Geoffrey Letchworth

Inventor： Kelley A. Smith ,  Steven R. Webb ,  Steven L. Evans ,  Charles A. Mihaliak ,  Donald J. Merlo ,  Geoffrey Letchworth

IPC: A61K38/00 ,  C12P21/04 ,  C07K16/00 ,  A61K31/70 ,  G01N33/53

CPC classification number: C12N15/8258 ,  A61K39/12 ,  A61K2039/55555 ,  A61K2039/55566 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/394

Abstract: The subject application provides various compositions of matter directed to West Nile virus (WNV) polypeptides and fragments thereof and polynucleotides, vectors and transformed host cells that encode, direct the expression of, or produce WNV polypeptides as set forth herein. Methods of using the polypeptides and polynucleotides for the production of immune responses in individuals or detecting the presence of WNV specific or neutralizing antibodies are also provided herein.

Abstract translation: 本申请提供针对西尼罗河病毒（WNV）多肽及其片段的物质的多种组合物，以及如本文所述编码，指导表达或产生WNV多肽的多核苷酸，载体和转化的宿主细胞。 本文还提供了使用多肽和多核苷酸在个体中产生免疫应答或检测WNV特异性或中和抗体的存在的方法。

公开(公告)号：US20080200570A1

公开(公告)日：2008-08-21

申请号：US12113364

申请日：2008-05-01

Applicant: Alan L. Browne ,  Ching-Shan Cheng ,  Nancy L. Johnson ,  Gary L. Jones ,  Scott R. Webb ,  Francis D. Wood ,  Ruth M. Gusko ,  Chin-Hsu Lin

Inventor： Alan L. Browne ,  Ching-Shan Cheng ,  Nancy L. Johnson ,  Gary L. Jones ,  Scott R. Webb ,  Francis D. Wood ,  Ruth M. Gusko ,  Chin-Hsu Lin

IPC: C08J9/00

CPC classification number: B60R21/04 ,  B60R19/00

Abstract: A method of operating a volume-filling structure, comprising sensing an impact event and expanding the volume-filling structure from a non-expanded state to an expanded state upon the sensed impact event. The volume-filling structure comprises an open celled material, a first end cap connected to one end of the open celled material and a second end cap connected to a second end of the open celled material. The volume-filling structure further includes an activation mechanism regulating expansion of the open celled material from the non-expanded state to expanded state in response to an activation signal, and the activation mechanism includes an actuator interfaced with the end caps. Embodiments may include triggering a pneumatic device to force the second end cap from the first end cap. Additionally, embodiments may include triggering a mechanical event to force the second end cap from the first end cap.

Abstract translation: 一种操作体积填充结构的方法，包括感测冲击事件并且在所感测到的碰撞事件时将体积填充结构从非展开状态扩展到展开状态。 体积填充结构包括开孔材料，连接到开孔材料的一端的第一端盖和连接到开孔组件的第二端的第二端盖。 体积填充结构还包括响应于激活信号而将开放细胞材料从非扩张状态扩展到膨胀状态的激活机构，并且激活机构包括与端盖接合的致动器。 实施例可以包括触发气动装置以迫使第二端盖从第一端盖。 另外，实施例可以包括触发机械事件以迫使第二端盖从第一端盖。

公开(公告)号：US20070160103A1

公开(公告)日：2007-07-12

申请号：US11715082

申请日：2007-03-06

Applicant: Palash Das ,  Khurshid Ahmed ,  Gregory Francis ,  Holger Glatzel ,  Alexei Lukashev ,  Jeremy Tyler ,  R. Webb

Inventor： Palash Das ,  Khurshid Ahmed ,  Gregory Francis ,  Holger Glatzel ,  Alexei Lukashev ,  Jeremy Tyler ,  R. Webb

IPC: H01S3/22

CPC classification number: B23K26/12 ,  B23K26/128 ,  B23K26/705 ,  G01J1/04 ,  G01J1/0418 ,  G01J1/4257 ,  G01J2001/0285 ,  G03F7/70025 ,  G03F7/70041 ,  G03F7/7055 ,  G03F7/70575 ,  G03F7/70933 ,  H01S3/005 ,  H01S3/0057 ,  H01S3/0071 ,  H01S3/02 ,  H01S3/03 ,  H01S3/036 ,  H01S3/038 ,  H01S3/0385 ,  H01S3/0404 ,  H01S3/041 ,  H01S3/08004 ,  H01S3/08009 ,  H01S3/0943 ,  H01S3/097 ,  H01S3/09705 ,  H01S3/0971 ,  H01S3/0975 ,  H01S3/104 ,  H01S3/105 ,  H01S3/1305 ,  H01S3/134 ,  H01S3/139 ,  H01S3/22 ,  H01S3/2207 ,  H01S3/223 ,  H01S3/225 ,  H01S3/2251 ,  H01S3/2256 ,  H01S3/2258 ,  H01S3/2333 ,  H01S3/2366

Abstract: A beam delivery unit and method of delivering a laser beam from a laser light source for excimer or molecular fluorine gas discharge laser systems in the DUV and smaller wavelengths is disclosed, which may comprise: a beam delivery enclosure defining an output laser light pulse beam delivery path from an output of a gas discharge laser to an input of a working apparatus employing the light contained in the output laser light pulse beam; a purge mechanism operatively connected to the beam delivery enclosure; an in-situ beam parameter monitor and adjustment mechanism within the enclosure, comprising a retractable beam redirecting optic; a beam analysis mechanism external to the enclosure; and, a retraction mechanism within the enclosure and operable from outside the enclosure and operative to move the retractable beam redirecting optic from a retracted position out of the beam path to an operative position in the beam path. The BDU may also include a beam attenuator unit contained within the enclosure adjustably mounted within the enclosure for positioning within the beam delivery path. The BDU may have at least two enclosure isolation mechanisms comprising a first enclosure isolation mechanism on a first side of the enclosure from the at least one optic module and a second enclosure isolation mechanism on a second side of the enclosure from the at least one optic module, each respective enclosure isolation mechanism comprising a flapper valve having a metal to metal seating mechanism and a locking pin assembly. A precision offset ratchet driver operative to manipulate actuator mechanisms in difficult to reach locations may be provided. An external kinematic alignment tool may be provided. A method of contamination control for a BDU is disclosed comprising selection of allowable materials and fabrication processes.

Abstract translation: 公开了一种束传递单元和从DUV和较小波长的准分子或分子氟气体放电激光系统的激光光源传送激光束的方法，其可以包括：限定输出激光束脉冲束传送 从气体放电激光器的输出到使用包含在输出激光脉冲光束中的光的工作装置的输入的路径; 可操作地连接到射束输送罩的清洗机构; 壳体内的原位光束参数监视和调节机构，包括可伸缩光束重定向光学元件; 外壳外部的光束分析机构; 以及在所述外壳内的收缩机构，并且可从所述外壳的外部操作，并且可操作地将所述可伸缩的束重定向光学器件从缩回位置移出所述光束路径到所述光束路径中的操作位置。 BDU还可以包括容纳在可调节地安装在外壳内的外壳内的光束衰减器单元，用于定位在光束输送路径内。 BDU可以具有至少两个机壳隔离机构，该机构包括位于外壳的第一侧面上的至少一个光学模块的第一外壳隔离机构和位于外壳的第二侧的第二外壳隔离机构，所述第二外壳隔离机构与所述至少一个光学模块 每个相应的外壳隔离机构包括具有金属对金属安置机构和锁销组件的挡板阀。 可以提供操作来操作难以到达位置的致动器机构的精密偏移棘轮驱动器。 可以提供外部运动学对准工具。 公开了一种用于BDU的污染控制方法，包括选择允许的材料和制造工艺。

公开(公告)号：US20060237092A1

公开(公告)日：2006-10-26

申请号：US11113651

申请日：2005-04-25

Applicant: R. Webb

Inventor： R. Webb

IPC: B65B1/04

CPC classification number: B67D7/78 ,  B60S5/02 ,  E04H1/1233

Abstract: An aboveground fueling facility includes one or more vertical fuel supply tanks, each of which is positioned on a reinforced mounting pad on a fueling island that also includes one or more fuel dispensers. Fuel is supplied from the vertical fuel supply tanks to the dispensers via piping that is secondarily contained within the reinforced mounting pad. Each of the vertical fuel supply tanks may have more than one compartment so as to permit different grades of fuel to be dispensed by the dispensers, including mixtures. Fueling lanes are defined between the vertical fuel supply tanks for permitting vehicular access to the fuel dispensers. A canopy for sheltering the fueling lanes is structurally supported by the vertical fuel supply tanks, and informational signage is provided on the canopy for providing information such as fuel pricing to the consumer.

Abstract translation: 地上加油设备包括一个或多个垂直燃料供应罐，每个立式燃料供应罐都位于加油岛上的加强安装垫上，该加压安装垫还包括一个或多个燃料分配器。 燃料从立式燃料供应罐通过管道供给到分配器，该管道被二次包含在加强的安装垫中。 每个垂直燃料供应罐可以具有多于一个隔室，以便允许由分配器（包括混合物）分配不同等级的燃料。 在立式燃料供应罐之间限定加油车道，以允许车辆进入燃料分配器。 用于庇护燃油通道的舱盖在垂直燃料供应罐的结构上得到支撑，并且在舱盖上提供信息标识，以向消费者提供燃料定价等信息。

公开(公告)号：US20060195078A1

公开(公告)日：2006-08-31

申请号：US11277477

申请日：2006-03-24

Applicant: R. Webb ,  Michael Brownell ,  Christopher Horvath ,  Tibor Juhasz ,  Ronald Kurtz ,  Leszlo Nagy ,  Mark Ross ,  Carlos Suarez

Inventor： R. Webb ,  Michael Brownell ,  Christopher Horvath ,  Tibor Juhasz ,  Ronald Kurtz ,  Leszlo Nagy ,  Mark Ross ,  Carlos Suarez

IPC: A61B18/18

CPC classification number: A61F9/009 ,  A61B2017/306 ,  A61F9/008 ,  A61F2009/00846

Abstract: An interface for coupling an eye to a surgical laser is disclosed. A lens cone includes a base ring opposite an apex ring. The base ring defines a first plane and is adapted to couple to the delivery tip of the laser such that the first plane has a predetermined position relative to the delivery tip. An applanation lens is affixed to the apex ring and has a surface disposed in a second plane such that the second plane is parallel to and has a predetermined position relative to the first plane. A gripper is engagable with the lens cone. An attachment ring is affixed to the gripper and is adapted to couple to the anterior surface of the eye. When the lens cone and gripper are engaged, the applanation lens contacts the anterior surface of the eye, placing the anterior surface in spatial registration with the delivery tip.

Abstract translation: 公开了一种用于将眼睛联接到手术激光器的界面。 透镜锥体包括与顶点环相对的基座环。 基座限定第一平面并且适于联接到激光器的输送末端，使得第一平面相对于输送末端具有预定位置。 压平透镜固定到顶点环上，并且具有设置在第二平面中的表面，使得第二平面相对于第一平面平行并具有预定位置。 夹具可与透镜锥接合。 附接环固定在夹持器上并适于联接到眼睛的前表面。 当透镜锥体和夹持器接合时，压平透镜接触眼睛的前表面，将前表面与输送尖端空间对准。

公开(公告)号：US07074617B1

公开(公告)日：2006-07-11

申请号：US09715891

申请日：2000-11-17

Applicant: Susan R. Webb ,  Ola Wingvist ,  Lars Karlsson ,  Michael R. Jackson ,  Per A. Peterson

Inventor： Susan R. Webb ,  Ola Wingvist ,  Lars Karlsson ,  Michael R. Jackson ,  Per A. Peterson

IPC: C12N15/12 ,  C12N5/06 ,  C12N15/63 ,  C07H21/04

CPC classification number: C07K14/70596 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C12N5/0601 ,  C12N2510/00 ,  Y10S424/81

Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

Abstract translation: 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。 这些基质用于激活幼稚的CD4 + T细胞，以及将正在进行的激活状态转移到Th1或Th2细胞的优选的分化群体中。

公开(公告)号：US06948231B2

公开(公告)日：2005-09-27

申请号：US10153333

申请日：2002-05-21

Applicant: Richard Hsiao ,  Quang Le ,  Paul P. Nguyen ,  Son Van Nguyen ,  Mustafa Pinarbasi ,  Patrick R. Webb ,  Howard G. Zolla

Inventor： Richard Hsiao ,  Quang Le ,  Paul P. Nguyen ,  Son Van Nguyen ,  Mustafa Pinarbasi ,  Patrick R. Webb ,  Howard G. Zolla

IPC: G11B5/17 ,  G11B5/31 ,  G11B5/39 ,  G11B5/127 ,  H04R31/00

CPC classification number: B82Y10/00 ,  G11B5/17 ,  G11B5/313 ,  G11B5/3163 ,  G11B5/3967 ,  Y10T29/49043 ,  Y10T29/49044 ,  Y10T29/49064 ,  Y10T29/49073

Abstract: The present invention presents a method for fabricating coil elements for magnetic write heads. A coil pattern is formed on a substrate using photolithographic techniques. The substrate is etched using reactive ion etching, creating a coil-shaped trench in the substrate. Thin film seed layers are deposited using ion beam deposition. The substrate is electroplated with metal filling the trenches with metal. The substrate is chemical mechanical polished to remove excess metal and planarize the air bearing surface of the write head.

Abstract translation: 本发明提供一种用于制造用于磁写头的线圈元件的方法。 使用光刻技术在衬底上形成线圈图案。 使用反应离子蚀刻蚀刻衬底，在衬底中产生线圈状沟槽。 使用离子束沉积沉积薄膜种子层。 用金属电镀衬底，用金属填充沟槽。 基板进行化学机械抛光以去除多余的金属并平面化写入头的空气轴承表面。

公开(公告)号：US06859998B2

公开(公告)日：2005-03-01

申请号：US10121989

申请日：2002-04-12

Applicant: James Kruger ,  Benjamin L. Wang ,  Patrick R. Webb ,  Howard G. Zolla

Inventor： James Kruger ,  Benjamin L. Wang ,  Patrick R. Webb ,  Howard G. Zolla

IPC: G11B5/187 ,  G11B5/31 ,  B44C1/22 ,  C23C14/04

CPC classification number: G11B5/1871 ,  G11B5/3116 ,  G11B5/3163 ,  Y10S29/016 ,  Y10T29/49032 ,  Y10T29/49041 ,  Y10T29/49043 ,  Y10T29/49046 ,  Y10T29/49052 ,  Y10T428/1186 ,  Y10T428/24174 ,  Y10T428/24479 ,  Y10T428/2462

Abstract: An article is formed as a substrate having a projection extending outwardly therefrom. The article may be a magnetic recording head and the projection a write pole. The projection has a width in a thinnest dimension measured parallel to a substrate surface of no more than about 0.3 micrometers and a height measured perpendicular to the substrate of not less than about 5 times the width. The article is fabricated by forming an overlying structure on the substrate with an edge thereon, depositing a replication layer lying on the edge, depositing a filler onto the edge and the substrate, so that the filler, the replication layer, and the overlying structure in combination comprise a continuous layer on the substrate, selectively removing at least a portion of the replication layer from a free surface of the continuous layer inwardly toward the substrate, to form a defined cavity, and depositing a projection material into the defined cavity to form the projection.

Abstract translation: 形成具有从其向外延伸的突起的基底的制品。 物品可以是磁记录头，并且投影是写柱。 突起具有平行于衬底表面测量的最薄尺寸的宽度不大于约0.3微米，垂直于衬底的高度不小于宽度的约5倍。 通过在其上具有边缘的衬底上形成覆盖结构来制造制品，沉积位于边缘上的复制层，在边缘和衬底上沉积填料，使得填料，复制层和上覆结构在 组合包括在衬底上的连续层，选择性地将复制层的至少一部分从连续层的自由表面向内移动到衬底，以形成限定的空腔，并将突出材料沉积到限定的空腔中以形成 投影。