公开(公告)号：US08946186B2

公开(公告)日：2015-02-03

申请号：US13847930

申请日：2013-03-20

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State

发明人： Douglas Lake ,  Benjamin Katchman

IPC分类号： C12N15/11 ,  C12Q1/68 ,  C12N15/113

CPC分类号： C12N15/1137 ,  C12Y108/03002 ,  C12N2310/14 ,  C12N2310/531

摘要： The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

摘要翻译： 本发明提供了通过施用静滴蛋白巯基氧化酶1（QSOX1）的抑制剂，包含这种抑制剂的组合物和鉴定这种抑制剂的方法来进行肿瘤治疗的方法。

公开(公告)号：US20140263693A1

公开(公告)日：2014-09-18

申请号：US14354177

申请日：2012-11-19

申请人： ARIZONA BOARD OF REGENTS, a body corporate of the state of Arizona, acting for and on behalf

发明人： R. Bruce Doak ,  John Spence ,  Uwe Weierstall

IPC分类号： B05B9/04 ,  B05D1/32 ,  B05D1/00 ,  B05B1/02 ,  B29C39/02

CPC分类号： B05B9/04 ,  B05B1/02 ,  B05B7/064 ,  B05B7/068 ,  B05B7/2483 ,  B05D1/005 ,  B05D1/32 ,  B29C39/02

摘要： A nozzle for producing a liquid jet a fluid, methods using the nozzle, and an injector comprising the nozzle of the invention for providing the liquid jet of a fluid to a vacuum system are described.

摘要翻译： 描述了用于产生液体喷射流体的喷嘴，使用喷嘴的方法，以及包括本发明的喷嘴的喷射器，用于将流体的液体射流提供给真空系统。

公开(公告)号：US20130295675A1

公开(公告)日：2013-11-07

申请号：US13927673

申请日：2013-06-26

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of

发明人： Bertram JACOBS ,  Stacy WHITE ,  Kip CONWELL ,  Jeffrey LANGLAND ,  James JANCOVICH

IPC分类号： C12N15/85

CPC分类号： C12N15/86 ,  C12N15/70 ,  C12N15/79 ,  C12N15/80 ,  C12N15/82 ,  C12N15/85 ,  C12N15/907 ,  C12N2710/24143 ,  C12N2800/40

摘要： The present invention provides reagents and methods for improved homologous recombination.

摘要翻译： 本发明提供用于改善同源重组的试剂和方法。

公开(公告)号：US20130193308A1

公开(公告)日：2013-08-01

申请号：US13724244

申请日：2012-12-21

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State

发明人： Oray Orkun Cellek ,  Yong-Hang Zhang

IPC分类号： H01L27/146 ,  H01L27/144

CPC分类号： H01L27/14621 ,  H01L27/144 ,  H01L31/02019 ,  H01L31/1013 ,  H01L31/105 ,  H01L31/109

摘要： Multi-band photodetectors can be formed by series connecting unipolar and, optionally, bipolar semiconductor structures, each having different photodetection bands. Under default mode of operation, the detector with highest resistance and lowest current will be the current limiting device and will be the active photodetector. When the active photodetector is illuminated with strong light in its own detection band it will be optically biased. This active photodetector will no longer be the highest resistance device, and the next photodetector will be the active photodetector. Repeating this operation pattern, allows switching photodetection bands of the multi-band photodetector. The resistances, dark current and photocurrent of the devices should be engineered to have proper switching. Moreover, the illuminating surface, and photodetector placement should be optimized for proper light biasing. The current passing through the device will always be equal to the current of the active photodetector.

摘要翻译： 多波段光电检测器可以通过串联连接单极和可选地双极半导体结构形成，每个具有不同的光电检测带。 在默认工作模式下，具有最高电阻和最低电流的检测器将是限流装置，并将作为有源光电检测器。 当有源光电探测器在其自身的检测带中用强光照射时，它将被光学偏置。 该有源光电检测器将不再是最高电阻器件，下一个光检测器将是有源光电检测器。 重复该操作模式，允许多频带光电探测器的开关光电检测带。 设备的电阻，暗电流和光电流应设计为具有适当的开关。 此外，应优化照明表面和光电检测器放置以适当的光偏置。 通过器件的电流将始终等于有源光电检测器的电流。

公开(公告)号：US20200172926A1

公开(公告)日：2020-06-04

申请号：US16513757

申请日：2019-07-17

申请人： Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Arizo ,  Consejo Superior De Investigaciones Cientificas ,  IPPOX Foundation

发明人： Giuseppe Pantaleo ,  Thierry Calandra ,  Alexandre Harari ,  Thierry Roger ,  Mario Esteban ,  Bertram Jacobs ,  Karen Kibler ,  Cornelius Melief ,  Rafick-Pierre Sekaly ,  Elias El Haddad ,  James Tartaglia

IPC分类号： C12N15/86 ,  A61K39/275 ,  A61K39/295

摘要： The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

公开(公告)号：US10370679B2

公开(公告)日：2019-08-06

申请号：US15289297

申请日：2016-10-10

申请人： Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Arizona State University ,  Consejo Superior De Investigaciones Cientificas ,  IPPOX Foundation

发明人： Giuseppe Pantaleo ,  Thierry Calandra ,  Alexandre Harari ,  Thierry Roger ,  Mariano Esteban ,  Bertram Jacobs ,  Karen Kibler ,  Cornelius Melief ,  Rafick-Pierre Sekaly ,  Elias El Haddad ,  James Tartaglia

IPC分类号： A61K39/275 ,  A61K39/295 ,  A61K39/12 ,  C12N15/86 ,  A61K49/00 ,  A61K39/00

摘要： The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

公开(公告)号：US09941089B2

公开(公告)日：2018-04-10

申请号：US15517917

申请日：2015-10-13

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University

发明人： Peter Williams ,  Karen Amanda Williams ,  Maitrayee Bose ,  John Prince

IPC分类号： H01J27/02 ,  H03L7/26 ,  H01H3/02 ,  H01J49/26

CPC分类号： H01J27/022 ,  H01H3/02 ,  H01J27/22 ,  H01J49/0004 ,  H01J49/26 ,  H03L7/26

摘要： A primary ion source subassembly for use with a secondary ion mass spectrometer may include a unitary graphite ionizer tube and reservoir base. A primary ion source may include a capillary insert defining an ionizer aperture. An ionizer aperture may be centrally arranged in an outwardly protruding conical or frustoconical surface, and may be overlaid with a refractory metal coating or sheath. Parameters including ionizer surface shape, ionizer materials, ionizer temperature, and beam stop plate orifice geometry may be manipulated to eliminate ghost images. A graphite tube gasket with a dual tapered surface may promote sealing of a source material cavity.

公开(公告)号：US20170204170A1

公开(公告)日：2017-07-20

申请号：US15390402

申请日：2016-12-23

申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona, Acting For and On Behalf of

发明人： Michael Sierks ,  Srinath Kasturirangan

IPC分类号： C07K16/18 ,  G01N33/68 ,  C07K16/00

CPC分类号： C07K16/18 ,  A61K38/1716 ,  A61K39/3955 ,  C07K16/005 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  G01N33/5438 ,  G01N33/54386 ,  G01N33/6857 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The invention relates to antibodies, antibody fragments and binding agents that specifically recognizes oligomeric Aβ that is resistant to denaturation by SDS but does not bind monomeric, fibrillar or other oligomeric forms of Aβ that are generated in vitro.

公开(公告)号：US09700712B2

公开(公告)日：2017-07-11

申请号：US13735716

申请日：2013-01-07

申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State University

发明人： Bruce C Towe

IPC分类号： A61N1/05 ,  H01P11/00 ,  A61N1/378 ,  H01Q9/00 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61N1/05 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3787 ,  H01P11/00 ,  H01Q9/00 ,  Y10T29/49018

摘要： Some embodiments include a dipolar antenna system to electrically power an implantable miniature device and/or to stimulate bioelectrically excitable tissue, such as, for example, through microelectronic neurostimulation. Other related systems and methods are also disclosed.

公开(公告)号：US20170182046A1

公开(公告)日：2017-06-29

申请号：US15398584

申请日：2017-01-04

申请人： Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting For and On Behalf of Ariz

发明人： Carl E. Wagner ,  Peter W. Jurutka ,  Pamela A. Marshall

IPC分类号： A61K31/505

CPC分类号： A61K31/505 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C2602/10 ,  C07D213/55 ,  C07D213/80 ,  C07D239/28

摘要： The invention provides compounds of formulae I, II, III, and IV: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.