公开(公告)号：US4175130A

公开(公告)日：1979-11-20

申请号：US889073

申请日：1978-03-22

Applicant: Tsutomu Yamanaka ,  Hiroshi Yasuda ,  Kunio Osuga

Inventor： Tsutomu Yamanaka ,  Hiroshi Yasuda ,  Kunio Osuga

IPC: C07D263/42 ,  C07D263/46 ,  C07D277/30 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D413/12 ,  C07D277/20

CPC classification number: C07D263/46 ,  C07D263/42 ,  C07D277/34 ,  C07D277/36

Abstract: Oxazole- and thiazole-alkanoic acid compounds useful as drugs for the treatment of atherosclerosis with lipid metabolism disorder, and having the formula: ##STR1## wherein R is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group, a pyridylmethyl group or a tocopheryl group; each of R.sup.1 and R.sup.2 is a hydrogen atom or a halogen atom; R.sup.3 is a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms; R.sup.4 is a hydrogen atom, a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a trifuloromethyl group; each of X and Y is an oxygen atom or a sulfur atom; and A is a straight or branched alkylene group having 1 to 4 carbon atoms, and pharmaceutically acceptable salts thereof are disclosed.

Abstract translation: 恶唑和噻唑 - 链烷酸化合物可用作用于用脂质代谢紊乱治疗动脉粥样硬化的药物，并具有下式：其中R是氢原子，具有1至4个碳原子的烷基，芳烷基， 吡啶基甲基或生育酚基; R1和R2各自为氢原子或卤素原子; R3是氢原子，卤原子或碳原子数1〜4的烷基。 R4是氢原子，卤素原子，硝基，碳原子数1〜4的烷基，碳原子数1〜4的烷氧基或三氟甲基; X和Y各自为氧原子或硫原子; A是具有1至4个碳原子的直链或支链亚烷基，并且其药学上可接受的盐被公开。

公开(公告)号：US4151288A

公开(公告)日：1979-04-24

申请号：US837961

申请日：1977-09-29

Applicant: Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

Inventor： Graham J. Durant ,  John C. Emmett ,  Charon R. Ganellin

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/495 ,  A61K31/496 ,  A61P29/00 ,  C07D213/32 ,  C07D213/38 ,  C07D213/65 ,  C07D213/70 ,  C07D213/74 ,  C07D231/12 ,  C07D233/64 ,  C07D233/68 ,  C07D233/84 ,  C07D233/90 ,  C07D235/06 ,  C07D237/08 ,  C07D249/08 ,  C07D249/12 ,  C07D261/08 ,  C07D263/46 ,  C07D275/02 ,  C07D275/03 ,  C07D277/22 ,  C07D277/26 ,  C07D277/36 ,  C07D277/48 ,  C07D285/12 ,  C07D285/135 ,  C07D471/04

CPC classification number: C07D213/70 ,  C07D213/32 ,  C07D213/38 ,  C07D213/65 ,  C07D213/74 ,  C07D231/12 ,  C07D233/84 ,  C07D233/90 ,  C07D235/06 ,  C07D249/08 ,  C07D249/12 ,  C07D261/08 ,  C07D263/46 ,  C07D275/02 ,  C07D275/03 ,  C07D277/26 ,  C07D285/135 ,  C07D471/04

Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.

Abstract translation: 化合物是作为组胺活性抑制剂的取代的硫代烷基 - ，氨基烷基 - 和氧烷基 - 硫脲和脲。

公开(公告)号：USRE29843E

公开(公告)日：1978-11-21

申请号：US807054

申请日：1977-06-16

Applicant: Alan O. Pittet ,  Denis E. Hruza

Inventor： Alan O. Pittet ,  Denis E. Hruza

IPC: A23L27/20 ,  A24B15/36 ,  C07D277/22 ,  C07D277/24 ,  C07D277/34 ,  C07D277/36 ,  C11B9/00

CPC classification number: C07D277/22 ,  A23L27/2056 ,  A24B15/36 ,  A24B15/365 ,  C07D277/24 ,  C07D277/36 ,  C11B9/0096

Abstract: Processes for altering the flavors and/or fragrances of materials which comprise adding thereto effective amounts of at least one thiazole having the formula: ##STR1## wherein R is hydrogen, alkyl, or acyl; X is .Iadd.alkyl, .Iaddend.alkoxy, .Iadd.or .Iaddend.hydrogen, .[.or when R and Y are alkyl, alkyl;.]. and Y is alkyl, acyl, alkoxy or hydrogen, no more than two of R, X and Y being hydrogen; .Iadd.with the proviso that X is alkyl only when either (i) R and Y are each alkyl or (ii) Y is alkoxy; .Iaddend.compositions containing such thiazoles and compositions; perfumed materials containing such thiazoles and compositions; and novel thiazoles and processes for producing same.

公开(公告)号：US4064258A

公开(公告)日：1977-12-20

申请号：US706342

申请日：1976-07-19

Applicant: Brian Lewis ,  Stefan H. Unger ,  Karl G. Untch

Inventor： Brian Lewis ,  Stefan H. Unger ,  Karl G. Untch

IPC: C07D277/20 ,  A61K31/426 ,  C07C17/26 ,  C07C31/137 ,  C07D277/36 ,  C07D277/56 ,  C07D417/12 ,  A61K31/425

CPC classification number: C07D277/56 ,  C07C31/137 ,  C07D277/36 ,  C07C2102/18

Abstract: 1-Alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine. Similarly the 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative can be prepared from the corresponding 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols via treatment with an aldehyde or ketone.

Abstract translation: 1-烷基氨基-3-（5-碳代环烷基氨基羰基噻唑-2-基氧基）-2-丙醇; 5-（5-碳代环烷基氨基羰基噻唑-2-基氧基亚甲基-N-烷基氮杂环丁烷和/或其2-取代的恶唑烷衍生物及其制备方法，该化合物表现出心血管活性，可用于治疗哺乳动物异常心脏病。 5-（5-碳代环烷基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基噻唑啉及其衍生物也是1-烷基氨基-3-（5-碳代环烷基氨基羰基噻唑-2-基） 1-烷基氨基-3-（5-碳代环烷基氨基羰基噻唑-2-基氧基）-2-丙氧基甲醇可以通过碱或水解相应的5-（5-碳代环烷基氨基羰基噻唑-2-基氧基亚甲基） ）-N-烷氧基唑烷或衍生物;或通过用所需的烷基胺处理相应的3-（5-碳代环烷基氨基羰基噻唑-2-基氧基）-2,3-环氧丙烷。类似地，5-（5-碳环烷基氨基羰基硫 唑烷-2-基氧基亚甲基）-N-烷氧基唑烷或衍生物可以通过用醛或酮处理由相应的1-烷基氨基-3-（5-碳代环烷基氨基羰基噻唑-2-基氧基）-2-丙醇的惰性醇制备。

公开(公告)号：US4061637A

公开(公告)日：1977-12-06

申请号：US576582

申请日：1975-05-12

Applicant: Elso Manghisi ,  Giuseppe Cascio ,  Giancarlo Fregnan

Inventor： Elso Manghisi ,  Giuseppe Cascio ,  Giancarlo Fregnan

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P1/04 ,  A61P29/00 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D417/06 ,  C07D491/10 ,  C07D491/113

CPC classification number: C07D491/10 ,  C07D277/34 ,  C07D277/36 ,  Y10S514/821 ,  Y10S514/925

Abstract: The invention provides novel 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their salts and complexes which have activity on the central nervous system, the cardio-vascular system, and anti-inflammatory, adrenolytic and anti-ulcer activity.

Abstract translation: 本发明提供了对中枢神经系统，心血管系统和抗炎，肾上腺素和抗溃疡活性具有活性的新的4-芳基-5-氨基烷基-4-噻唑啉-2-酮及其盐和配合物 。

公开(公告)号：US4038288A

公开(公告)日：1977-07-26

申请号：US569243

申请日：1975-04-18

Applicant: Thomas Andrew Lies ,  James Wellington Clapp

Inventor： Thomas Andrew Lies ,  James Wellington Clapp

IPC: C07D277/36 ,  C07D295/21 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28 ,  C07D333/00

CPC classification number: C07D295/21 ,  C07D277/36 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28

Abstract: The present invention relates to certain novel dithiocarbamate esters, methods for their synthesis and their use as bactericidal and fungicidal agents.

公开(公告)号：US4022607A

公开(公告)日：1977-05-10

申请号：US584885

申请日：1975-06-09

Applicant: Thomas E. Jackson

Inventor： Thomas E. Jackson

IPC: C07D263/46 ,  C07D277/36 ,  A01N9/12 ,  A01N9/14

CPC classification number: C07D263/46 ,  C07D277/36

Abstract: Substituted oxazoles and thiazoles are useful as herbicides.

Abstract translation: 取代的恶唑和噻唑可用作除草剂。

公开(公告)号：US4011230A

公开(公告)日：1977-03-08

申请号：US567664

申请日：1975-04-14

Applicant: Thomas Andrew Lies ,  James Wellington Clapp

Inventor： Thomas Andrew Lies ,  James Wellington Clapp

IPC: C07D277/36 ,  C07D295/21 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28 ,  C07D401/12 ,  C07D403/12

CPC classification number: C07D295/21 ,  C07D277/36 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28

Abstract: The present invention relates to certain novel dithiocarbamate esters, methods for their synthesis and their use as bactericidal and fungicidal agents.

公开(公告)号：US3996208A

公开(公告)日：1976-12-07

申请号：US344020

申请日：1973-03-21

Applicant: Bruno Fechtig ,  Karoly Kocsis ,  Hans Bikel

Inventor： Bruno Fechtig ,  Karoly Kocsis ,  Hans Bikel

IPC: C07D207/34 ,  C07D213/75 ,  C07D213/78 ,  C07D233/90 ,  C07D241/22 ,  C07D277/36 ,  C07D307/68 ,  C07D499/00 ,  C07D499/64 ,  C07D501/20 ,  C07F7/18 ,  C07D499/46

CPC classification number: C07D213/75 ,  C07D207/34 ,  C07D213/78 ,  C07D233/90 ,  C07D241/22 ,  C07D277/36 ,  C07D307/68 ,  C07D499/00 ,  C07F7/1896

Abstract: 6-acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, and R is a radical which is linked through a carbon, oxygen, sulphur or nitrogen atom.

Abstract translation: 6-酰基氨基 - penam-3-羧酸和7-酰基氨基-3-头孢烯-4-羧酸，其中酰基具有式“IMAGE”，其中R 1是氢，R 2是任选取代的苯基，噻吩基或呋喃基，或 R1和R2一起是任选取代的环烷基，R是通过碳，氧，硫或氮原子连接的基团。

公开(公告)号：US3989710A

公开(公告)日：1976-11-02

申请号：US497356

申请日：1974-08-14

Applicant: Klaus Sasse ,  Gunther Beck ,  Ludwig Eue

Inventor： Klaus Sasse ,  Gunther Beck ,  Ludwig Eue

IPC: A01N47/02 ,  A01N47/06 ,  A01N47/10 ,  A01N47/18 ,  A01N47/20 ,  C07D277/20 ,  C07D277/36 ,  C07D277/74 ,  C07D417/12

CPC classification number: C07D277/36

Abstract: Novel carbonic acid derivatives of 2-mercapto-4,5-dichloro-thiazole which has the formula ##SPC1##In whichX is oxygen or sulfurY is a radical -OR, -SR or ##EQU1## are outstandingly effective herbicides exhibiting particularly pronounced post-emergence activity.

Abstract translation: 2-巯基-4,5-二氯 - 噻唑的新型碳酸衍生物，其具有式I，其中X是氧或硫，Y是基团-OR，-SR或R 1 -N ANGLE R 2是显着特别显着的柱 出生活动。