公开(公告)号：US11598718B2

公开(公告)日：2023-03-07

申请号：US16972345

申请日：2019-06-07

申请人： The University of York

发明人： Matthew Baker ,  Neil T. Hunt ,  Samantha Rutherford ,  Gordon Hithell

IPC分类号： G01N21/3577 ,  G01N21/63 ,  G01N33/49 ,  G01N21/35

摘要： A method of analysing an aqueous fluid comprising obtaining a 2D-IR spectrum of a sample of the aqueous fluid using a 2D-IR spectrometer configured to apply a sequence of IR pulses to the sample, wherein the sequence comprises a pump process followed by a probe pulse, where the pump process is a single pump pulse or a sequence of a first pump pulse and a second pump pulse, and a waiting time Tw between applying the single pump pulse or the second pump pulse and applying the probe pulse is from 150 to 350 fs.

公开(公告)号：US11596724B2

公开(公告)日：2023-03-07

申请号：US17374817

申请日：2021-07-13

申请人： Samsung Electronics Co., Ltd.

发明人： Jinho Oh ,  Huisung Moon ,  Minyoung Lee ,  Manseung Heo

IPC分类号： A61M1/36 ,  A61M1/34 ,  G01N33/49

摘要： A filter and a device including the filter may include a filter and a plurality of pores arranged two-dimensionally on the filter. The plurality of pores may include a plurality of first pores having a longer structure in a certain direction and a plurality of second pores having a longer structure in a direction different from that of the first pore. The first and second pores may have a two-dimensional arrangement in order to suppress or prevent the occurrence of cracks in the filter due to stress.

公开(公告)号：US20230061350A1

公开(公告)日：2023-03-02

申请号：US17779370

申请日：2020-11-24

申请人： ABBOTT DIABETES CARE INC.

发明人： Yongjin XU ,  Timothy C. DUNN

IPC分类号： G01N33/72 ,  G16H20/17 ,  G01N33/49 ,  A61B5/00 ,  G16H50/20

摘要： Physiological parameters that related to the kinetics of red blood cell hemoglobin glycation, red blood cell elimination, and red blood cell generation within the body of a subject can be used, for example, to calculate a more reliable calculated HbA1c (cHbA1c), adjusted HbA1c (aHbA1c), and/or a personalized target glucose range, among other things, for subject-personalized diagnoses, treatments, and/or monitoring protocols. Such physiological parameters may be determined using a model that considers cross-membrane glucose transport and glycation.

公开(公告)号：US11579139B2

公开(公告)日：2023-02-14

申请号：US17559841

申请日：2021-12-22

申请人： LabThroughput LLC

发明人： David Zelmanovic ,  John Roche

IPC分类号： G01N33/49 ,  G01N15/10 ,  G01N15/06 ,  G01N21/53 ,  G01N15/14 ,  G01N21/59 ,  G01N15/00

摘要： A method for measuring concentrations of blood cell components is provided. The method comprises: obtaining a blood sample from a subject, the blood sample comprising at least one of red blood cells (RBCs), white blood cells (WBCs), and platelets (PLTs); mixing the blood sample with a non-lysing aqueous solution to form a sample mixture comprising a predetermined tonicity; passing the sample mixture through a flow cell; emitting light towards the flow cell; measuring at least one of an amount of light absorbed by the RBCs to obtain an RBC absorption value, an amount of light scattered by WBCs to obtain a WBC scatter value, and an amount of light scattered by PLTs to obtain a PLT scatter value; and determining a concentration of at least one of the RBCs, WBCs, and PLTs present in the sample mixture.

公开(公告)号：US20230042775A1

公开(公告)日：2023-02-09

申请号：US17960727

申请日：2022-10-05

申请人： Cypher Medical, LLC

发明人： Christopher A. CAREW ,  JIan LING

IPC分类号： G01N33/49 ,  G01N15/05 ,  G01N9/02 ,  G01N1/40 ,  A61J1/00

摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include the use of an RBC flocculant, for example polyDADMAC, and an approximate blood hematocrit from the type of animal blood being evaluated, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal blood hematocrit, and a calculated RBC packing ratio “n” value for the collection device. A collection device with a BIP is disclosed. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml -1,500 ml) and veterinary (about 500 ml - 2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

公开(公告)号：US11564577B2

公开(公告)日：2023-01-31

申请号：US17514778

申请日：2021-10-29

申请人： OMNI MEDSCI, INC.

发明人： Mohammed N. Islam

IPC分类号： G01J3/00 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/14 ,  G01J3/453 ,  G01J3/42 ,  G01J3/02 ,  G01N21/35 ,  G16H40/67 ,  G01N21/359 ,  A61B5/145 ,  G01N33/15 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  A61B5/1455 ,  G16Z99/00 ,  A61C19/04 ,  G01N21/3504 ,  H01S3/30 ,  G01J3/18 ,  G01J3/12 ,  G01N21/85 ,  G01N21/95 ,  H01S3/067 ,  H01S3/00 ,  G01M3/38 ,  A61C1/00

摘要： An optical system measures one or more physiological parameters with a wearable device that includes a light emitting diode (LED) source including a driver and a plurality of semiconductor sources that generate an output optical light. One or more lenses deliver a lens output light to tissue of a user. A detection system receives at least a portion of the lens output light reflected from the tissue and generates an output signal having a signal-to-noise ratio. The detection system comprises a plurality of spatially separated detectors and an analog to digital converter. The detection system increases the signal-to-noised ratio by comparing a first signal with the LEDs off to a second signal with the LEDs on. An imaging system including a Bragg reflector is pulsed and has a near infrared wavelength. A beam splitter splits the light into a sample arm and a reference arm to measure time-of-flight.

公开(公告)号：US20230028910A1

公开(公告)日：2023-01-26

申请号：US17789340

申请日：2020-11-13

申请人： SCAILYTE AG ,  UNIVERSITAT ZURICH

发明人： Peter NESTOROV ,  Vijay Kumar TIWARI ,  Manfred CLAASSEN ,  Philip KNUCKLES ,  Sarah HAMILTON CARL ,  Emmanuella GUENOVA ,  Christina FASSNACHT ,  Eleni Maria VARYPATAKI

IPC分类号： G01N33/50 ,  G01N33/574 ,  G01N33/49 ,  G01N33/563 ,  G16H50/30

摘要： The present invention relates to a method for diagnosing Sézary syndrome or mycosis fungoides in a subject. The present invention further relates to a method for determining the frequency of Sézary signature cells and/or mycosis fungoides cells in a sample. Further, the present invention relates to a computer-implemented method comprising a classifier algorithm to determine the frequency of Sézary signature cells and/or mycosis fungoides cells. In addition the present invention relates to a panel of biomarkers that can be used for the diagnosis of Sézary syndrome or mycosis fungoides.

公开(公告)号：US20230024462A1

公开(公告)日：2023-01-26

申请号：US17813006

申请日：2022-07-15

申请人： Techcyte, Inc. ,  NanoSpot.AI, Inc.

发明人： Benjamin Cahoon ,  Richard Smith ,  Shane Swenson ,  Bryan Worthen ,  Russ Zimmerman ,  Vanessa Redecke ,  Hans Haecker ,  Mark Astill ,  Rian Wendling

IPC分类号： G16H10/40 ,  G16H10/60 ,  G01N33/49 ,  G01N33/487

摘要： Protecting information by partitioning data across multiple storage resources. A method includes receiving an image of a test card and an identity of a patient associated with the test card. The method includes associating the image of the test card with the identity of the patient as a data pair on a first storage resource. The method includes providing the image of the test card to a second storage resource by way of a network, wherein the first storage resource is independent of the second storage resource. The method includes receiving a result for the test card and associating the result for the test card with the identity of the patient based on the data pair stored on the first storage resource.

公开(公告)号：US20230023536A1

公开(公告)日：2023-01-26

申请号：US17932687

申请日：2022-09-16

申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

发明人： Daniel T. CHIU ,  Mengxia ZHAO ,  Wyatt NELSON ,  Perry G. SCHIRO

IPC分类号： G01N33/574 ,  B01L3/00 ,  G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N21/64 ,  G01N33/53

摘要： Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

公开(公告)号：US20230012920A1

公开(公告)日：2023-01-19

申请号：US17659702

申请日：2022-04-19

申请人： COR HEALTH, INC.

发明人： Robert G. MESSERSCHMIDT

IPC分类号： G01N21/25 ,  A61B5/151 ,  G01N33/49

摘要： A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.