公开(公告)号：US20230027904A1

公开(公告)日：2023-01-26

申请号：US17779318

申请日：2020-11-24

申请人： ABBOTT DIABETES CARE INC.

发明人： Yongjin XU ,  Timothy C. DUNN

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61M5/172 ,  G16H10/40

摘要： A method for deriving physiological parameters may include: measuring a glucose level of a subject over time; measuring a HbA1c of individual red blood cells in a sample comprising a plurality of red blood cells; deriving a measured cellular HbA1c distribution of the sample; and calculating at least one physiological parameter selected from the group consisting of (a) a red blood cell elimination constant (kage), (b) a red blood cell glycation rate constant (kgly), and/or (c) an apparent glycation constant (K) based on the measured cellular HbA1c distribution and the glucose levels of the subject over time.

公开(公告)号：US20240225559A1

公开(公告)日：2024-07-11

申请号：US18611402

申请日：2024-03-20

申请人： Abbott Diabetes Care Inc.

发明人： Erwin Satrya BUDIMAN ,  Kenneth J. DONIGER ,  Timothy C. DUNN ,  Nathan C. CROUTHER ,  Glenn BERMAN ,  Howard A. WOLPERT

IPC分类号： A61B5/00 ,  A61B5/145 ,  G01N33/66 ,  G16H15/00 ,  G16H20/10 ,  G16H50/30 ,  G16Z99/00

CPC分类号： A61B5/7275 ,  A61B5/14532 ,  A61B5/4848 ,  A61B5/7282 ,  A61B5/742 ,  G01N33/66 ,  G16H20/10 ,  G16H50/30 ,  G16Z99/00 ,  A61B5/4836 ,  A61B5/746 ,  G16H15/00

摘要： A system and method provides a glucose report for determining glycemic risk based on an ambulatory glucose profile of glucose data over a time period, a glucose control assessment based on median and variability of glucose, and indicators of high glucose variability. Time of day periods are shown at which glucose levels can be seen. A median glucose goal and a low glucose line provide coupled with glucose variability provide a view into effects that raising or lowering the median goal would have. Likelihood of low glucose, median glucose compared to goal, and variability of glucose below median provide probabilities based on glucose data. Patterns can be seen and provide guidance for treatment.

公开(公告)号：US20230061350A1

公开(公告)日：2023-03-02

申请号：US17779370

申请日：2020-11-24

申请人： ABBOTT DIABETES CARE INC.

发明人： Yongjin XU ,  Timothy C. DUNN

IPC分类号： G01N33/72 ,  G16H20/17 ,  G01N33/49 ,  A61B5/00 ,  G16H50/20

摘要： Physiological parameters that related to the kinetics of red blood cell hemoglobin glycation, red blood cell elimination, and red blood cell generation within the body of a subject can be used, for example, to calculate a more reliable calculated HbA1c (cHbA1c), adjusted HbA1c (aHbA1c), and/or a personalized target glucose range, among other things, for subject-personalized diagnoses, treatments, and/or monitoring protocols. Such physiological parameters may be determined using a model that considers cross-membrane glucose transport and glycation.

公开(公告)号：US20220280122A1

公开(公告)日：2022-09-08

申请号：US17742088

申请日：2022-05-11

申请人： Abbott Diabetes Care Inc.

发明人： Timothy C. DUNN ,  Kenneth J. DONIGER ,  Glenn BERMAN ,  Gary A. HAYTER ,  Erwin S. BUDIMAN ,  Daniel M. BERNSTEIN ,  Nathan CROUTHER

IPC分类号： A61B5/00 ,  A61B5/145 ,  G16H50/20

摘要： A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.