公开(公告)号：US08974830B2

公开(公告)日：2015-03-10

申请号：US13772958

申请日：2013-02-21

Applicant: Canon Kabushiki Kaisha

Inventor： Shinzaburo Ito ,  Kengo Kanazaki ,  Tatsuki Fukui ,  Fumiko Tomatsu ,  Masato Minami ,  Tetsuya Yano ,  Hiroyuki Aoki

IPC: A61K9/14 ,  A61K49/22 ,  A61K9/16 ,  A61K49/00

CPC classification number: A61K49/222 ,  A61K9/1647 ,  A61K49/0036 ,  A61K49/0093

Abstract: A particle includes a copolymer of lactic acid and glycolic acid, and at least one compound selected from silicon naphthalocyanine and derivatives of silicon naphthalocyanine, in which the particle has a particle size of 10 nm or more and less than 1000 nm.

Abstract translation: 颗粒包括乳酸和乙醇酸的共聚物，以及至少一种选自硅萘酞菁和硅萘酞菁衍生物的化合物，其中颗粒的粒径为10nm以上且小于1000nm。

公开(公告)号：US20150050219A1

公开(公告)日：2015-02-19

申请号：US14385585

申请日：2013-03-12

Applicant: BBS S.r.l.

Inventor： Mauro Beccaro

IPC: A61K47/24 ,  A61K31/025 ,  A61K9/00

CPC classification number: A61K47/24 ,  A61K9/0048 ,  A61K31/025 ,  A61K49/0036

Abstract: First, a coloured solution is claimed, comprising at least one perfluorocarbon as a solvent and a dye dissolved in the perfluorocarbon and selected from the family of fluorinated derivatives of phthalocyanines obtained by substituting one or more of the hydrogen H atoms linked to the benzene rings with a fluorine atom or a fluorinated group, for use in surgical methods for the treatment of the bodies of humans or animals, in particular in surgical methods of vitreoretinal surgery where the coloured solution acts as a retinal tamponade. Second, a coloured solution is claimed, comprising at least one perfluorocarbon selected from perfluorooctane, perfluorodecalin and perfluorophenanthrene as a solvent and a dye dissolved in the perfluorocarbon and selected from the family indicated above. The dye, in general, is preferably selected from the family of metalpoly(fluoroalkyl)phthalocyanines and even more preferably of metalpoly(perfluoroalkyl)phthalocyanines.

Abstract translation: 首先，要求保护有色溶液，其包含至少一种全氟化碳作溶剂和溶于全氟化碳中的染料，并且选自通过用一个或多个与苯环连接的氢H原子取代的酞菁的氟化衍生物族， 氟原子或氟化基团，用于治疗人或动物的外科手术方法，特别是在有色溶液作为视网膜填塞物的玻璃体视网膜手术的手术方法中。 其次，要求保护有色溶液，其中包含至少一种选自全氟辛烷，全氟萘烷和全氟菲作为溶剂的全氟化碳和溶解在全氟化碳中的染料，并选自上述家族。 通常，染料优选选自金属聚（氟代烷基）酞菁，甚至更优选金属聚（全氟烷基）酞菁。

公开(公告)号：US20140276107A1

公开(公告)日：2014-09-18

申请号：US14351770

申请日：2012-10-12

Applicant: Photocure ASA

Inventor： Ketil Widerberg

IPC: A61K49/00 ,  A61B5/00

CPC classification number: A61K49/0052 ,  A61B5/0071 ,  A61K41/00 ,  A61K49/0036

Abstract: This invention relates to the diagnosis of abnormalities of the epithelial-lined surface of the esophagus and, in particular, to the use of esters of 5-aminolevulinic acid (5-ALA) in methods of photodynamic diagnosis (PDD) of Barrett's esophagus and in diagnostic methods which monitor the progression of the disease with high specificity.

Abstract translation: 本发明涉及食管上皮内表面异常的诊断，尤其涉及在Barrett食管的光动力学诊断（PDD）方法中使用5-氨基乙酰丙酸（5-ALA）的酯类和 以高特异性监测疾病进展的诊断方法。

公开(公告)号：US08815213B2

公开(公告)日：2014-08-26

申请号：US12920088

申请日：2009-03-01

Applicant: Avigdor Scherz ,  Liat Goldshaid ,  Yoram Salomon

Inventor： Avigdor Scherz ,  Liat Goldshaid ,  Yoram Salomon

IPC: A61B5/055 ,  A61K51/04 ,  A61K41/00 ,  C07D257/04

CPC classification number: A61K51/0485 ,  A61K41/0057 ,  A61K41/0071 ,  A61K49/0036 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/14 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0451 ,  A61K51/082 ,  A61K51/088 ,  C07D257/04

Abstract: RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and/or on-line prognosis of necrotic tumors.

Abstract translation: 家庭和积累在坏死肿瘤域中的RGD-叶绿素和RGD-细菌叶绿素缀合物比在肿瘤非坏死区域中长得多的时间被提供用于微创肿瘤靶向成像，肿瘤靶向光动力学治疗和/或在线预后 的坏死性肿瘤。

公开(公告)号：US20140235973A1

公开(公告)日：2014-08-21

申请号：US14212557

申请日：2014-03-14

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Gary M Brittenham ,  Herbert Stepp ,  Georg Hennig

IPC: A61B5/1455 ,  G02B26/00 ,  A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/14546 ,  A61B5/7275 ,  A61B5/74 ,  A61K49/0036 ,  G02B26/001

Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.

Abstract translation: 一种用于通过在两个波长范围内激发血液和分析物来无限量地测量患者血液中的荧光分析物浓度的装置和方法，并且当（i）激发时的发射强度差异时，测量荧光分析物的发射光谱 荧光分析物的波长范围大于背景荧光团的波长范围，（ii）当两个激发波长范围的吸光度相似时。 提供了一种用于测量患者血液中荧光分析物浓度的装置和方法。

公开(公告)号：US20140170073A1

公开(公告)日：2014-06-19

申请号：US14015363

申请日：2013-08-30

Applicant: The Ohio State University Research Foundation

Inventor： Periannan Kuppusamy ,  Ramasamy P. Pandian ,  Narasimham L. Parinandi ,  Jay L. Zweier

IPC: A61K49/10 ,  C07F1/02

CPC classification number: A61K49/10 ,  A61K49/0036 ,  A61K49/1818 ,  A61K49/20 ,  B82Y5/00 ,  C07F1/02 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62

Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

Abstract translation: 一类新型的微粒子和纳米颗粒顺磁性自旋探针，特别适用于磁共振成像技术，包括电子顺磁共振（EPR）和磁共振成像（MRI）。 探针是锂酞菁衍生物化合物。 还提供了包含锂酞菁衍生物探针的悬浮液和乳液。 还提供了用于在体内或体外测量特定组织，器官或细胞中的氧浓度，氧分压，氧代谢和一氧化氮浓度的无创方法的非侵入性方法。

公开(公告)号：US08652441B2

公开(公告)日：2014-02-18

申请号：US12893074

申请日：2010-09-29

Applicant: Tatsuki Fukui ,  Fumio Yamauchi ,  Satoshi Yuasa ,  Sachiko Inoue

Inventor： Tatsuki Fukui ,  Fumio Yamauchi ,  Satoshi Yuasa ,  Sachiko Inoue

IPC: A61B10/00 ,  A61B8/00 ,  A61B5/00

CPC classification number: C07D209/58 ,  A61K41/00 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0093 ,  C07D209/60 ,  C07D209/62 ,  C07D487/22 ,  C09B23/0033 ,  C09B23/0066 ,  C09B23/086 ,  C09B47/0673

Abstract: A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.

Abstract translation: 检测光声成像造影剂的方法提供高信号强度。 在用于光声成像的造影剂中，含有无机材料的每个颗粒通过化学键合至少支持在近红外区域具有吸收系数的有机染料。

公开(公告)号：US20130315837A1

公开(公告)日：2013-11-28

申请号：US13960377

申请日：2013-08-06

Applicant: Canon Kabushiki Kaisha

Inventor： Fumiko Tomatsu ,  Tatsuki Fukui ,  Kengo Kanazaki ,  Satoshi Yuasa ,  Mayuko Kishi ,  Daisuke Sasaguri

IPC: A61K49/22

CPC classification number: A61K49/22 ,  A61K49/0036 ,  A61K49/0078 ,  A61K49/226 ,  B82Y30/00 ,  C07D487/22 ,  C09B67/0005 ,  C09B67/0013 ,  C09B67/009 ,  C09B69/008

Abstract: An object of the present invention is to increase the dye content in nanoparticles and to improve the signal intensity per particle. According to the nanoparticle including at least a silicon naphthalocyanine or a derivative thereof and a surfactant, wherein the proportion of the silicon naphthalocyanine or the derivative thereof is 70% or more by weight in relation to the other component of the particle exclusive of the surfactant, the dye content in the nanoparticles can be increased and the signal intensity per particle can be improved without weakening the signal intensity per dye molecule (light absorptivity)

Abstract translation: 本发明的目的是增加纳米颗粒中的染料含量并提高每个颗粒的信号强度。 根据包含至少一种硅萘酞菁或其衍生物和表面活性剂的纳米颗粒，其中相对于不含表面活性剂的颗粒的其它组分，硅萘酞菁或其衍生物的比例为70重量％以上， 可以增加纳米颗粒中的染料含量，并且可以提高每个颗粒的信号强度，而不会削弱每个染料分子的信号强度（光吸收率）

公开(公告)号：US20130237688A1

公开(公告)日：2013-09-12

申请号：US13863145

申请日：2013-04-15

Applicant: HEALTH RESEARCH, INC. ,  THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

Inventor： Ravindra K. Pandey ,  Suresh Pandey ,  Lalit Goswami ,  Allan Oseroff ,  Shipra Dubey ,  Munawwar Sajjad

IPC: C07K7/06

CPC classification number: C07K7/06 ,  A61B5/02007 ,  A61B5/416 ,  A61K41/0071 ,  A61K47/54 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0056 ,  A61K51/082 ,  A61K51/088

Abstract: A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is 11C, 18F, 64Cu, 124I, 99Tc, 111In or GdIII and its method of use for diagnosing, imaging and/or treating hyperproliferative tissue such as tumors. Preferably the photosensitizer is a tumor avid tetrapyrollic photosensitizer, e.g. a porphyrin, chlorin or bacteriochlorin, e.g. pheophorbides and pyropheophorbides. Such conjugates have extreme tumor avidity and can be used to inhibit or completely destroy the tumor by light absorption. The integrin is usually αvβ3, α5β1, αvβ5, α4β1, or α2β1. Preferably, the antagonist is an RGD peptide or another antagonist that may be synthetic such as a 4-{2-(3,4,5,6-tetra-hydropyrimidin-2-ylamino)ethyloxy}-benzoyl]amino-2-(S)-amino-ethyl-sulfonylamino group. Such compounds provide tumor avidity and imaging ability thus permitting selective and clear tumor imaging.

Abstract translation: 作为拮抗剂与由肿瘤细胞表达的整联蛋白结合的化合物，以及至少一种肿瘤病毒四级光敏剂，荧光染料和放射性同位素标记部分，其中放射性同位素为11C，18F，64Cu，124I，99Tc ，111In或GdIII及其用于诊断，成像和/或治疗过度增生组织如肿瘤的方法。 优选地，光敏剂是肿瘤急性四分光敏光敏剂，例如。 卟啉，二氢卟酚或细菌二氢卟酚。 脱镁叶绿素和焦偏镁偏磷酸盐。 这种缀合物具有极端的肿瘤亲合力，可用于通过光吸收抑制或完全破坏肿瘤。 整合素通常是alphavbeta3，alpha5beta1，alphavbeta5，alpha4beta1或alpha2beta1。 优选地，拮抗剂是可以是合成的RGD肽或另一种拮抗剂，例如4- {2-（3,4,5,6-四 - 嘧啶-2-基氨基）乙氧基} - 苯甲酰基]氨基-2-（ S） - 氨基 - 乙基 - 磺酰基氨基。 这样的化合物提供了肿瘤亲合力和成像能力，从而允许选择性和清晰的肿瘤成像。

公开(公告)号：US20130178787A1

公开(公告)日：2013-07-11

申请号：US13809093

申请日：2011-07-08

Applicant: Bjorn Klem ,  Norbert Lange

Inventor： Bjorn Klem ,  Norbert Lange

IPC: A61K31/197 ,  A61N5/06

CPC classification number: A61K31/197 ,  A61K9/19 ,  A61K9/7007 ,  A61K41/0061 ,  A61K49/0017 ,  A61K49/0036 ,  A61N5/0601 ,  A61N5/062

Abstract: This invention relates to dry pharmaceutical compositions comprising an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA, or a pharmaceutically acceptable salt thereof. The compositions may be used in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions. The invention relates further to irradiation devices comprising dry compositions and the use of such devices in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions.

Abstract translation: 本发明涉及包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐的干燥药物组合物。 组合物可用于癌症，癌前病症和非癌症病症的光动力学治疗（PDT）或光动力学诊断（PDD）。 本发明进一步涉及包含干组合物的照射装置以及在光动力学治疗（PDT）或癌症，癌前病症和非癌症病症的光动力学诊断（PDD）中使用这些装置。