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公开(公告)号：US10004858B2
公开(公告)日：2018-06-26
申请号：US13932757
申请日：2013-07-01
发明人： Gerald C. Smaldone , Lucy B. Palmer
CPC分类号： A61M15/009 , A61M11/00 , A61M11/06 , A61M16/0057 , A61M16/04 , A61M16/0463 , A61M16/0465 , A61M16/0484 , A61M16/08 , A61M16/0808 , A61M16/0833
摘要： The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.
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2.发明授权公开(公告)号：US09945863B2
公开(公告)日：2018-04-17
申请号：US14107306
申请日：2013-12-16
发明人： M. Saeed Sheikh , Ying Huang , Jie An
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/5743 , G01N33/57484
摘要： Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.
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公开(公告)号：US20170044450A1
公开(公告)日：2017-02-16
申请号：US15305985
申请日：2015-04-21
发明人： David J. WAAGE
摘要： A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior.
摘要翻译： 气化器系统包括用于接收湿原料的反应器，其具有基部和可旋转地连接到基部的容器，使得容器的旋转导致原料在反应器内部的混合。 内部由基座和容器限定。 基座和容器之间的空间允许氧进入内部。 该空间具有这样的尺寸，使得原料在邻近基底的燃烧区域中被完全氧化，并且使得原料避免了在其余内部的燃烧。 反应器具有相对于水平线倾斜倾斜的纵向轴线，以促进原料在内部的混合。
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公开(公告)号：US09530048B2
公开(公告)日：2016-12-27
申请号：US14311814
申请日：2014-06-23
申请人： The Regents of the University of California , The Research Foundation of State University of New York
CPC分类号： G06K9/00335 , G06K9/00281 , G06K9/00288 , G06K9/00315 , G06K9/4652 , G06K9/6256 , G06K9/66
摘要： An automatic facial action coding system and method can include processing an image to identify a face in the image, to detect and align one or more facial features shown in the image, and to define one or more windows on the image. One or more distributions of pixels and color intensities can be quantified in each of the one or more windows to derive one or more two-dimensional intensity distributions of one or more colors within the window. The one or more two-dimensional intensity distributions can be processed to select image features appearing in the one or more windows and to classify one or more predefined facial actions on the face in the image. A facial action code score that includes a value indicating a relative amount of the predefined facial action occurring in the face in the image can be determined for the face in the image for each of the one or more predefined facial actions.
摘要翻译： 自动面部动作编码系统和方法可以包括处理图像以识别图像中的脸部，以检测和对准图像中所示的一个或多个面部特征，并且定义图像上的一个或多个窗口。 可以在一个或多个窗口中的每一个中量化像素和颜色强度的一个或多个分布，以导出窗口内的一种或多种颜色的一个或多个二维强度分布。 可以处理一个或多个二维强度分布以选择出现在一个或多个窗口中的图像特征，并对图像中的脸部上的一个或多个预定义的面部动作进行分类。 可以针对一个或多个预定义的面部动作中的每一个为图像中的面部确定包括指示出现在图像中的面部中的预定面部动作的相对量的值的面部动作代码分数。
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公开(公告)号：US20160130354A1
公开(公告)日：2016-05-12
申请号：US14800429
申请日：2015-07-15
CPC分类号： C07K16/2896 , A61K38/168 , A61K47/6825 , A61K47/6851 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , G01N33/82
摘要： The present invention provides anti-TCblR antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer, tumors and other proliferative diseases and disorders.
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公开(公告)号：US09012158B2
公开(公告)日：2015-04-21
申请号：US14284805
申请日：2014-05-22
发明人： Julian L. Ambrus, Jr. , Long Shen
IPC分类号： G01N33/53 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6893 , G01N33/564 , G01N2333/47 , G01N2333/988 , G01N2800/04 , G01N2800/101
摘要： Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-1), parotid secretory protein (PSP), carbonic anhydrase 6 (CA6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided.
摘要翻译： 提供了用于确定个体是否具有索格伦氏病（SD）的方法和组合物。 该方法需要在来自个体的生物样品中确定针对唾液腺蛋白1（SP-1），腮腺分泌蛋白（PSP），碳酸酐酶6（CA6）的抗体的存在或确定抗体的组合。 确定个体具有SD是基于抗体的存在。 该方法提供早期SD的检测。 还提供了包含SD患者抗体所针对的抗原的抗体检测试剂盒。
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公开(公告)号：US20140301636A1
公开(公告)日：2014-10-09
申请号：US14311814
申请日：2014-06-23
申请人： The Regents of the University of California , The Research Foundation of State University of New York
CPC分类号： G06K9/00335 , G06K9/00281 , G06K9/00288 , G06K9/00315 , G06K9/4652 , G06K9/6256 , G06K9/66
摘要： An automatic facial action coding system and method can include processing an image to identify a face in the image, to detect and align one or more facial features shown in the image, and to define one or more windows on the image. One or more distributions of pixels and color intensities can be quantified in each of the one or more windows to derive one or more two-dimensional intensity distributions of one or more colors within the window. The one or more two-dimensional intensity distributions can be processed to select image features appearing in the one or more windows and to classify one or more predefined facial actions on the face in the image. A facial action code score that includes a value indicating a relative amount of the predefined facial action occurring in the face in the image can be determined for the face in the image for each of the one or more predefined facial actions.
摘要翻译： 自动面部动作编码系统和方法可以包括处理图像以识别图像中的脸部，以检测和对准图像中所示的一个或多个面部特征，并且定义图像上的一个或多个窗口。 可以在一个或多个窗口中的每一个中量化像素和颜色强度的一个或多个分布，以导出窗口内的一种或多种颜色的一个或多个二维强度分布。 可以处理一个或多个二维强度分布以选择出现在一个或多个窗口中的图像特征，并对图像中的脸部上的一个或多个预定义的面部动作进行分类。 可以针对一个或多个预定义的面部动作中的每一个为图像中的面部确定包括指示出现在图像中的面部中的预定面部动作的相对量的值的面部动作代码分数。
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公开(公告)号：US20140277293A1
公开(公告)日：2014-09-18
申请号：US14207114
申请日：2014-03-12
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Jared Jagdeo , Roslyn Rivkah Isseroff , Andrew Mamalis , Neil Brody , Daniel Siegel , Hadar Lev-Tov
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61N2005/0651 , A61N2005/0659 , A61N2005/0663
摘要： Methods for LED generated low-level light therapy (LLLT) in the red, blue, and IR ranges are described to effectively inhibit fibroblast proliferation in vitro without altering viability, and may be used as therapy for the treatment of scars and other proliferative skin diseases.
摘要翻译： 描述了红色，蓝色和红外范围内LED产生低水平光疗法（LLLT）的方法，可有效抑制体外成纤维细胞增殖而不改变活力，可用作治疗瘢痕和其他增生性皮肤病的治疗方法 。
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公开(公告)号：US20140272342A1
公开(公告)日：2014-09-18
申请号：US14212559
申请日：2014-03-14
IPC分类号： C09D181/02
CPC分类号： C09D181/02 , Y10T428/24942
摘要： Embodiments of films and material layers comprising PEDOT. These embodiments are the result of methods that utilize polymerization processes including vapor phase polymerization (VPP) to form the conductive film comprising PEDOT. In one embodiment, the film can result from a method that includes steps for depositing a coating solution onto a substrate, exposing the substrate to a monomer source, and cleaning the subsrate after polymerization. The coating solution can comprise an initiating oxidant, which facilitates growth of PEDOT from 3,4 ethylenedioxythiophene (EDOT), as well as a quenching agent that neutralizes acid that results from polymerization.
摘要翻译： 包括PEDOT的膜和材料层的实施方案。 这些实施方案是利用包括气相聚合（VPP）在内的聚合方法形成包含PEDOT的导电膜的方法的结果。 在一个实施方案中，膜可以由包括将涂布溶液沉积到基材上的步骤的方法产生，将基材暴露于单体源，并在聚合后清洗该沉淀物。 涂层溶液可以包含引发氧化剂，其促进PEDOT从3,4-亚乙二氧噻吩（EDOT）的生长，以及中和聚合产生的酸的淬灭剂。
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公开(公告)号：US20140255955A1
公开(公告)日：2014-09-11
申请号：US14284805
申请日：2014-05-22
发明人： Julian L. Ambrus, JR. , Long Shen
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/564 , G01N2333/47 , G01N2333/988 , G01N2800/04 , G01N2800/101
摘要： Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-1), parotid secretory protein (PSP), carbonic anhydrase 6 (CA6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided.
摘要翻译： 提供了用于确定个体是否具有索格伦氏病（SD）的方法和组合物。 该方法需要在来自个体的生物样品中确定针对唾液腺蛋白1（SP-1），腮腺分泌蛋白（PSP），碳酸酐酶6（CA6）的抗体的存在或确定抗体的组合。 确定个体具有SD是基于抗体的存在。 该方法提供早期SD的检测。 还提供了包含SD患者抗体所针对的抗原的抗体检测试剂盒。
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