公开(公告)号：US08465482B2

公开(公告)日：2013-06-18

申请号：US13443713

申请日：2012-04-10

Applicant: Simon W. H. Thomas ,  Peter S. Edelstein ,  John T. To ,  Benjamin T. Nordell ,  Stuart D. Edwards

Inventor： Simon W. H. Thomas ,  Peter S. Edelstein ,  John T. To ,  Benjamin T. Nordell ,  Stuart D. Edwards

IPC: A61B18/18

CPC classification number: A61B18/00 ,  A61B17/0625 ,  A61B18/02 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2017/00805 ,  A61B2017/00867 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00178 ,  A61B2018/00285 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00916 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2218/007 ,  A61N1/06 ,  A61N7/022 ,  C08L2201/12

Abstract: Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

公开(公告)号：US20100256713A1

公开(公告)日：2010-10-07

申请号：US12144575

申请日：2008-06-23

Applicant: Stuart D. Edwards ,  Peter H. Muller ,  Thomas C. Wehman

Inventor： Stuart D. Edwards ,  Peter H. Muller ,  Thomas C. Wehman

IPC: A61F7/12

CPC classification number: A61B18/082 ,  A61B1/00082 ,  A61B1/005 ,  A61B1/018 ,  A61B1/267 ,  A61B1/273 ,  A61B1/303 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61F5/0003

Abstract: Minimally invasive apparatus and method for treating medical conditions of hollow organs. The treatment apparatus and method provide for delivery of energy from fluid sources of energy to the interior surface of the hollow organ in contact with the underlying glands, nerves, and muscle walls of the organ.

Abstract translation: 微创装置及治疗中空器官病态的方法。 治疗装置和方法提供能量从能量源传递到与器官的下面的腺体，神经和肌肉壁接触的中空器官的内表面。

公开(公告)号：US20100168733A1

公开(公告)日：2010-07-01

申请号：US12648249

申请日：2009-12-28

Applicant: STUART D. EDWARDS ,  SIMON W. H. THOMAS

Inventor： STUART D. EDWARDS ,  SIMON W. H. THOMAS

IPC: A61B18/18

CPC classification number: A61N1/0514 ,  A61B18/18 ,  A61B2018/0212 ,  A61N1/06 ,  A61N1/403

Abstract: The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.

Abstract translation: 本发明包括一种用于治疗身体部位的方法和装置。 更具体地，描述了使用插入到身体部分中的导管来热处理组织的方法和装置，以及用于定位导管的装置和用于相对于组织样本定位一组电极的装置用于治疗。 更具体地，使用约400至500千赫兹的射频能量来为组织处理提供热量。

公开(公告)号：US20100114087A1

公开(公告)日：2010-05-06

申请号：US12494871

申请日：2009-06-30

Applicant: Stuart D. Edwards ,  Charles S. Carignan ,  Simon Thomas

Inventor： Stuart D. Edwards ,  Charles S. Carignan ,  Simon Thomas

IPC: A61B18/18

CPC classification number: A61M25/1002 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/445 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00469 ,  A61B2017/00805 ,  A61B2017/22074 ,  A61B2018/00011 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00505 ,  A61B2018/00553 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/046 ,  A61B2034/2063 ,  A61B2090/3925 ,  A61M2025/0086 ,  A61M2025/0087

Abstract: Described herein are devices, systems and methods for treatment of tissue within a lumen of a body. For example, the devices described herein may be used to treat the urethra or gastrointestinal tract, including a sphincter. These devices may provide an expandable element at the distal end of an elongate body and may also include a plurality of electrodes (e.g., needle electrodes) configured to extend from the device and into the tissue to deliver energy to multiple, circumferentially arranged treatment sites. Sufficient energy may be delivered from the device to create a desired tissue effect.

Abstract translation: 本文描述了用于治疗身体内腔内的组织的装置，系统和方法。 例如，本文所述的装置可用于治疗尿道或胃肠道，包括括约肌。 这些装置可以在细长主体的远端处提供可扩张元件，并且还可以包括多个电极（例如针电极），其被配置为从装置延伸到组织中以将能量传递到多个周向布置的治疗部位。 可以从装置输送足够的能量以产生期望的组织效应。

公开(公告)号：US20090254142A1

公开(公告)日：2009-10-08

申请号：US12108499

申请日：2008-04-23

Applicant: Stuart D. Edwards ,  Peter H. Muller ,  Thomas C. Wehman

Inventor： Stuart D. Edwards ,  Peter H. Muller ,  Thomas C. Wehman

IPC: A61N1/04

CPC classification number: A61F5/0026 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61F5/0079 ,  A61F5/0083

Abstract: A minimally invasive treatment and appartus for treating medical conditions of hollow organs is described. Electrodes positioned within the organ and in surface contact with the underlying glands, nerves, and muscle walls of the organ apply energy to specific glandular, nerve, or muscular areas to alter the organ's operation.

Abstract translation: 描述了一种用于治疗中空器官的医疗状况的微创治疗方法。 位于器官内并与器官的下面的腺体，神经和肌肉壁相接触的电极对特定的腺体，神经或肌肉区域施加能量以改变器官的手术。

公开(公告)号：US07585296B2

公开(公告)日：2009-09-08

申请号：US11230801

申请日：2005-09-20

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley

IPC: A61B18/18

CPC classification number: A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00039 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00142 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00982 ,  A61B2018/0237 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2090/064 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06

Abstract: A method detects at a tissue site an electrical activity causing a transient relaxation of at least a portion of one of a sphincter, a lower esophageal sphincter, a stomach, a cardia or a fundus. The method treats the electrical activity at the tissue site by delivering electromagnetic energy to ablate at least a portion of one of the nerve, the gastric nerve, a nerve plexus, a myenteric nerve plexus, a ganglia, a nerve pathway or an electrically conductive pathway. The method conducts a cooling solution to the tissue site at a flow rate and adjusts the flow rate in response to sensed temperature conditions.

Abstract translation: 一种方法在组织位置处检测导致括约肌，下食道括约肌，胃，贲门或眼底之一的至少一部分的暂时松弛的电活动。 该方法通过传递电磁能来消除组织部位的电活动，以消融神经，胃神经，神经丛，肌间神经丛，神经节，神经通路或导电通路中的至少一部分 。 该方法以流量对组织部位进行冷却溶液，并根据感测的温度条件调节流速。

公开(公告)号：US20090131928A1

公开(公告)日：2009-05-21

申请号：US12315423

申请日：2008-12-03

Applicant: Stuart D. Edwards ,  David Utley

Inventor： Stuart D. Edwards ,  David Utley

IPC: A61B18/18

CPC classification number: A61B18/1485 ,  A61B18/00 ,  A61B18/08 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/148 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22062 ,  A61B2017/22072 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00738 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/0262 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2090/3966 ,  A61B2218/002 ,  A61F7/12 ,  A61M3/0279 ,  A61M16/0454 ,  A61M16/0459 ,  A61M16/0481 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61N1/056 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40 ,  A61N7/02 ,  C08L2201/12

Abstract: An apparatus includes an expandable member. The expandable member is sized to be positionable in a sphincter. An energy delivery device is positioned on a surface of the expandable member. The energy delivery device has a configuration that provides sufficient energy delivery to create lesions in the interior of the sphincter. When the expandable member is removed from the sphincter, the sphincter returns to its closed or contracted configuration.

Abstract translation: 一种装置包括可扩张构件。 可扩张构件的大小可定位在括约肌中。 能量输送装置位于可膨胀构件的表面上。 能量输送装置具有提供足够的能量输送以在括约肌内部产生损伤的构造。 当可伸缩构件从括约肌中取出时，括约肌返回到其闭合或收缩的构型。

公开(公告)号：US07122031B2

公开(公告)日：2006-10-17

申请号：US10024747

申请日：2001-12-19

Applicant: Stuart D Edwards ,  John W. Gaiser ,  David S Utley ,  Scott H. West ,  Jay Qin

Inventor： Stuart D Edwards ,  John W. Gaiser ,  David S Utley ,  Scott H. West ,  Jay Qin

IPC: A61B18/18

CPC classification number: A61B18/1233 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00488 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007 ,  Y10S128/922

Abstract: Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.

公开(公告)号：US07081125B2

公开(公告)日：2006-07-25

申请号：US10795955

申请日：2004-03-08

Applicant: Stuart D. Edwards ,  Ronald Lax ,  Theodore L. Parker ,  Thomas C. Wehman ,  Theodore Kucklick

Inventor： Stuart D. Edwards ,  Ronald Lax ,  Theodore L. Parker ,  Thomas C. Wehman ,  Theodore Kucklick

IPC: A61B17/08 ,  A61B18/18

CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B17/3415 ,  A61B18/14 ,  A61B18/1482 ,  A61B18/1487 ,  A61B2017/00084 ,  A61B2017/00495 ,  A61B2017/005 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672 ,  A61B2017/3441 ,  A61B2017/3492 ,  A61B2018/0063 ,  A61B2090/064 ,  A61M25/0662

Abstract: A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.

公开(公告)号：US20060058780A1

公开(公告)日：2006-03-16

申请号：US11207677

申请日：2005-08-18

Applicant: Stuart D. Edwards ,  Simon W. H. Thomas

Inventor： Stuart D. Edwards ,  Simon W. H. Thomas

IPC: A61F2/00

CPC classification number: A61N1/06 ,  A61N1/403

Abstract: The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.