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公开(公告)号：US07632268B2
公开(公告)日：2009-12-15
申请号：US11420712
申请日：2006-05-26
Applicant: Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
Inventor： Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
CPC classification number: A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
Abstract: Systems for treating a mucosal surface of an alimentary canal tissue region are provided. The systems can include an elongate support structure, an expandable member positionable at a distal portion of the support structure and one or more radio frequency (RF) ablation electrodes carried by the expandable member. The elongate support structure and the expandable member can be adapted to place the one or more electrodes in contact with a mucosal surface of an alimentary canal tissue region. The system can further include an RF energy source connected to the one or more electrodes.
Abstract translation: 提供了用于治疗消化道组织区域的粘膜表面的系统。 该系统可以包括细长的支撑结构，可定位在支撑结构的远端部分处的可扩张构件以及由可扩张构件承载的一个或多个射频（RF）消融电极。 细长支撑结构和可扩张构件可适于将一个或多个电极与消化道组织区域的粘膜表面接触。 该系统还可以包括连接到一个或多个电极的RF能量源。
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公开(公告)号：US06866663B2
公开(公告)日：2005-03-15
申请号：US10254471
申请日：2002-09-25
Applicant: Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
Inventor： Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
CPC classification number: A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
Abstract: A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
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公开(公告)号：US20100063495A1
公开(公告)日：2010-03-11
申请号：US12620924
申请日：2009-11-18
Applicant: Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
Inventor： Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
IPC: A61B18/18
CPC classification number: A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
Abstract: Systems for treating a mucosal surface of an alimentary canal tissue region are provided. The systems can include an elongate support structure, an expandable member positionable at a distal portion of the support structure and one or more radio frequency (RF) ablation electrodes carried by the expandable member. The elongate support structure and the expandable member can be adapted to place the one or more electrodes in contact with a mucosal surface of an alimentary canal tissue region. The system can further include an RF energy source connected to the one or more electrodes.
Abstract translation: 提供了用于治疗消化道组织区域的粘膜表面的系统。 该系统可以包括细长的支撑结构，可定位在支撑结构的远端部分处的可扩张构件以及由可扩张构件承载的一个或多个射频（RF）消融电极。 细长支撑结构和可扩张构件可适于将一个或多个电极与消化道组织区域的粘膜表面接触。 该系统还可以包括连接到一个或多个电极的RF能量源。
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公开(公告)号：US20090076438A1
公开(公告)日：2009-03-19
申请号：US12291626
申请日：2008-11-12
Applicant: Stuart D. Edwards , David S. Utley , Ronald G. Lax , John Gaiser
Inventor： Stuart D. Edwards , David S. Utley , Ronald G. Lax , John Gaiser
IPC: A61B17/12
CPC classification number: A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
Abstract: A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
Abstract translation: 用于治疗括约肌的方法提供具有液体状态的聚合物材料。 该方法还提供了具有远端的导管，由远端承载的组织刺穿装置，以及耦合到组织刺穿装置的能量输送装置。 组织穿刺装置具有内腔。 该方法将导管引入食道并刺穿组织穿刺装置内的外括约肌组织表面。 该方法使组织穿刺装置进入内部括约肌组织部位，并将液体状态下的聚合物材料通过内腔输送到内括约肌组织部位。 该方法将能量传递到组织刺穿装置，以将聚合物材料转变成内部括约肌组织部位内的较少液体状态，从而改变括约肌。
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5.发明授权Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 有权通过检测和消融胃食管神经和受体来治疗胃反流的方法公开(公告)号：US07585296B2
公开(公告)日：2009-09-08
申请号：US11230801
申请日：2005-09-20
Applicant: Stuart D Edwards , John Gaiser , David S Utley
Inventor： Stuart D Edwards , John Gaiser , David S Utley
IPC: A61B18/18
CPC classification number: A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00039 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00142 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/00898 , A61B2018/0091 , A61B2018/00982 , A61B2018/0237 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2090/064 , A61B2090/3782 , A61B2218/002 , A61N1/06
Abstract: A method detects at a tissue site an electrical activity causing a transient relaxation of at least a portion of one of a sphincter, a lower esophageal sphincter, a stomach, a cardia or a fundus. The method treats the electrical activity at the tissue site by delivering electromagnetic energy to ablate at least a portion of one of the nerve, the gastric nerve, a nerve plexus, a myenteric nerve plexus, a ganglia, a nerve pathway or an electrically conductive pathway. The method conducts a cooling solution to the tissue site at a flow rate and adjusts the flow rate in response to sensed temperature conditions.
Abstract translation: 一种方法在组织位置处检测导致括约肌，下食道括约肌，胃，贲门或眼底之一的至少一部分的暂时松弛的电活动。 该方法通过传递电磁能来消除组织部位的电活动，以消融神经，胃神经，神经丛，肌间神经丛，神经节，神经通路或导电通路中的至少一部分 。 该方法以流量对组织部位进行冷却溶液，并根据感测的温度条件调节流速。
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Patent Agency Ranking
6.发明授权Systems and methods for forming composite lesions to treat dysfunction in sphincters and adjoining tissue regions 有权用于形成复合损伤以治疗括约肌和邻近组织区域的功能障碍的系统和方法公开(公告)号：US06712074B2
公开(公告)日：2004-03-30
申请号：US10155294
申请日：2002-05-24
Applicant: Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
Inventor： Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
IPC: A61B1900
CPC classification number: A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
Abstract: Systems and methods manipulate a support structure to form a composite lesion in a tissue region at or near a sphincter. The support structure carries an array of electrodes attachable to a source of energy capable of heating tissue when transmitted by the electrodes. The systems and methods advance the electrodes to penetrate the tissue region and form, when the energy is transmitted, a first pattern of lesions. The systems and methods retract the electrodes, and shift the position of the electrodes, either rotationally, or axially, or both rotationally and axially. The systems and methods advance the electrodes a second time to form, when the energy is transmitted, a second pattern of lesions either rotationally or axially or both rotationally and axially shifted from the first pattern of lesions. The first and second patterns of lesion together comprise the composite lesion.
Abstract translation: 系统和方法操纵支撑结构以在括约肌处或附近的组织区域中形成复合损伤。 支撑结构带有可连接到能够通过电极传输的能够加热组织的能量源的电极阵列。 系统和方法使电极穿过组织区域并在能量传输时形成第一种损伤模式。 系统和方法缩回电极，并且可旋转地或轴向地或者旋转地和轴向地移动电极的位置。 系统和方法第二次推进电极，当能量传递时，可以旋转地或轴向地或者从第一病变图案旋转地和轴向移动的第二病变图案。 病灶的第一和第二模式一起构成复合损伤。
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7.发明授权Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 失效通过检测和消融胃食管神经和受体来治疗胃反流的方法公开(公告)号：US06405732B1
公开(公告)日：2002-06-18
申请号：US09410448
申请日：1999-10-01
Applicant: Stuart D. Edwards , John Gaiser , David S. Utley
Inventor： Stuart D. Edwards , John Gaiser , David S. Utley
IPC: A61B1900
CPC classification number: A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00039 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00142 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/00898 , A61B2018/0091 , A61B2018/00982 , A61B2018/0237 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2090/064 , A61B2090/3782 , A61B2218/002 , A61N1/06
Abstract: A method of treating a sphincter provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity.
Abstract translation: 治疗括约肌的方法提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。
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公开(公告)号：US08518032B2
公开(公告)日：2013-08-27
申请号：US12291626
申请日：2008-11-12
Applicant: Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
Inventor： Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
Abstract: A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
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公开(公告)号：US20090254079A1
公开(公告)日：2009-10-08
申请号：US12456091
申请日：2009-06-11
Applicant: Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
Inventor： Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
IPC: A61B18/18
CPC classification number: A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
Abstract: Methods treat a tissue region. In one arrangement, the methods deploy an endoscope in an esophagus and visualize with the endoscope a Z-line that marks a transition between esophageal tissue and stomach tissue by observing tissue color change at or near the Z-line. The methods deploy an electrode support structure over the endoscope at or near the Z-line visualized by the endoscope, wherein the endoscope serves as a guide for the electrode support structure. The methods introduce from the electrode support structure a tissue-piercing needle electrode into tissue at or near the Z-line and observe introduction of the tissue-piercing needle electrode using the endoscope. The methods couple the tissue-piercing electrode to a source of radio frequency energy to ohmically heat tissue and create a subsurface tissue lesion in tissue at or near the Z-line, and observe creation of the tissue lesion using the endoscope.
Abstract translation: 方法治疗组织区域。 在一种布置中，该方法在食道中部署内窥镜并且通过观察Z线处或附近的组织颜色变化，通过内窥镜观察标记食管组织和胃组织之间转变的Z线。 该方法在由内窥镜可视化的Z线处或附近在内窥镜上部署电极支撑结构，其中内窥镜用作电极支撑结构的引导件。 所述方法从电极支撑结构将组织穿刺针电极引入到Z线处或附近的组织中，并且使用内窥镜观察组织穿刺针电极的引入。 该方法将组织刺穿电极耦合到射频能量源以欧姆加热组织并在Z线或其附近的组织中产生表面下组织损伤，并且使用内窥镜观察组织损伤的产生。
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公开(公告)号：US07556628B2
公开(公告)日：2009-07-07
申请号：US11420722
申请日：2006-05-26
Applicant: David S Utley , John Gaiser , Stuart D Edwards , Scott H West , Jay Qin
Inventor： David S Utley , John Gaiser , Stuart D Edwards , Scott H West , Jay Qin
IPC: A61B18/18
CPC classification number: A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
Abstract: Methods of ablating mucosal tissue in an alimentary canal are provided. The methods can include the steps of (i) providing an ablation device comprising a tissue ablation source; (ii) positioning at least a portion of the ablation device at a mucosal tissue surface of the alimentary canal; (iii) delivering a sufficient amount of the source for tissue ablation to the mucosal tissue surface to create a lesion in the mucosal tissue. In one implementation the methods include a step of providing a radiofrequency (RF) energy delivery device.
Abstract translation: 提供消化道中消融粘膜组织的方法。 所述方法可以包括以下步骤：（i）提供包括组织消融源的消融装置; （ii）将消融装置的至少一部分定位在消化道的粘膜组织表面; （iii）将足够量的用于组织消融的来源输送到粘膜组织表面以在粘膜组织中产生损伤。 在一个实现中，所述方法包括提供射频（RF）能量传递装置的步骤。
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