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461 条记录 (耗时 0.025 秒)

    Method of producing polysaccharide derivatives
    92.
    发明授权
    Method of producing polysaccharide derivatives 有权
    多糖衍生物的制备方法

    公开(公告)号：US08557986B2

    公开(公告)日：2013-10-15

    申请号：US12299091

    申请日：2007-04-27

    申请人： Yousuke Yasuda

    发明人： Yousuke Yasuda

    IPC分类号： C07D251/46

    CPC分类号： C07D251/46 ,  A61K47/61 ,  C08B37/0072

    摘要： A polysaccharide derivative having a high solubility in an aqueous solvent is produced. The production method of the present invention uses a compound shown by the general formula (1) as a condensing agent and allows a polysaccharide having a carboxyl group to react with an an organic compound having a functional group capable of condensing with the carboxyl group to prepare the polysaccharide derivative: R1 and R2 independently represent a substituent selected among alkyl groups of 1 to 4 carbon atoms and aryl groups of 6 to 8 carbon atoms; Z−represents a counter anion; and E+represents an organic group shown as: R3, R4, and R5 independently represent an organic group having at least one carbon atom directly bound to a quaternary nitrogen atom and any two or all of R3, R4, and R5 may link together to form a cyclic structure.

    摘要翻译： 制备在水性溶剂中具有高溶解度的多糖衍生物。 本发明的制造方法使用通式（1）所示的化合物作为缩合剂，使具有羧基的多糖与具有能够与羧基缩合的官能团的有机化合物反应，制备 多糖衍生物：R1和R2独立地表示选自1至4个碳原子的烷基和6至8个碳原子的芳基的取代基; Z-表示抗衡阴离子; 并且E +表示如下所示的有机基团：R 3，R 4和R 5独立地表示具有至少一个碳原子与季氮原子结合的有机基团，并且R 3，R 4和R 5中的任何两个或全部可以连接至 形成循环结构。

    Adsorbents for protein purification
    94.
    发明授权
    Adsorbents for protein purification 有权
    用于蛋白质纯化的吸附剂

    公开(公告)号：US08076477B2

    公开(公告)日：2011-12-13

    申请号：US12281346

    申请日：2007-03-02

    申请人： Jason Richard Betley ,  Helen Tatton ,  Kelly Le Riche ,  Matthew Webb

    发明人： Jason Richard Betley ,  Helen Tatton ,  Kelly Le Riche ,  Matthew Webb

    IPC分类号： C07D251/46 ,  C07D251/52 ,  C07D251/54 ,  C07D251/38 ,  C07D251/30 ,  A61K31/53 ,  B01J20/22 ,  G01N30/00

    CPC分类号： C07D251/48 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/3251 ,  B01J20/3255 ,  Y10T436/25375 ,  Y10T436/255

    摘要： Use of an affinity adsorbent for the separation, removal, isolation, purification, characterisation, identification or quantification of a proteinaceous material, wherein the affinity adsorbent is a compound of formula (III), wherein R1 is H, alkyl, aryl, hydroxyalkyl, cyciohexyl, amino or a heterocyclic group which is optionally substituted with one or more of alkyl, aryl, alkoxy, aryloxy, acyloxy, acylamino, amino, OH, CO2H, sulphonyl, carbamoyl, sulphamoyl, alkylsuiphonyl and halogen; one X is N and the other is N, C—Cl or C—CN; Y is O, S or NR2; Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; Q is benzene, naphthalene, benzthiazole, benzoxazole, 1-phenylpyrazole, indazoie or benzimidazoie; R4, R5 and R6 are each H, OH, alkyl, aryl, heterocyclic, alkoxy, aryloxy, amino, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, suiphamoyl, alkylsulphonyl or halogen, or two or more of R4, R5 and R6 are linked to form a cyclic structure; U and V are the same or different C1-10 straight-chain alkylene groups optionally substituted by one or more of hydroxyl, alkyl, aryl, hydroxyl, alkyl, β-phenylethyl and halogen; and A is a support matrix optionally linked to the X-containing ring by a spacer.

    摘要翻译： 使用亲和吸附剂来分离，去除，分离，纯化，表征，鉴定或定量蛋白质物质，其中亲和吸附剂是式（III）化合物，其中R 1是H，烷基，芳基，羟基烷基，环己基 氨基或杂环基，其任选被一个或多个烷基，芳基，烷氧基，芳氧基，酰氧基，酰氨基，氨基，OH，CO 2 H，磺酰基，氨基甲酰基，氨磺酰基，烷基磺酰基和卤素取代; 一个X为N，另一个为N，C-Cl或C-CN; Y是O，S或NR2; Z是O，S或NR 3; R 2和R 3各自为H，烷基，羟基烷基，苄基或苯乙基; Q是苯，萘，苯并噻唑，苯并恶唑，1-苯基吡唑，indazoie或苯并咪唑; R4，R5和R6各自为H，OH，烷基，芳基，杂环，烷氧基，芳氧基，氨基，酰氧基，酰氨基，CO2H，磺酸，氨基甲酰基，磺酰基，烷基磺酰基或卤素，或R4，R5和R6中的两个或多个 连接形成环状结构; U和V是相同或不同的任选被羟基，烷基，芳基，羟基，烷基，苯基乙基和卤素中的一个或多个取代的C 1-10直链亚烷基; 并且A是通过间隔物任选地连接到含X环的支撑基体。