公开(公告)号：US20050233453A1

公开(公告)日：2005-10-20

申请号：US11098417

申请日：2005-04-05

Applicant: Yutaka Kariya ,  Mamoru Kyogashima ,  Kiyoshi Suzuki ,  Yousuke Yasuda

Inventor： Yutaka Kariya ,  Mamoru Kyogashima ,  Kiyoshi Suzuki ,  Yousuke Yasuda

IPC: A61K35/12 ,  A61K35/28 ,  A61P7/00 ,  A61P35/02 ,  C08B37/00 ,  C08B37/10 ,  C12N5/07 ,  C12N5/074 ,  C12N5/0775 ,  C12N5/0789 ,  C12N5/08

CPC classification number: C08B37/0063 ,  A61K2035/124 ,  C08B37/0075 ,  C12N5/0647 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2501/91

Abstract: A 6-O-sulfated N-acetylheparosan in which a primary hydroxyl group of N-acetylglucosamine constituting N-acetylheparosan is sulfated; a hematopoietic stem cell growth auxiliary agent, which has hematopoietic stem cell growth-accelerating activity and comprises the 6-O-sulfated-N-acetylheparosan as an active ingredient; a medium for a hematopoietic stem cell, which comprises the hematopoietic stem cell growth auxiliary agent and an other medium component necessary for culturing the hematopoietic stem cell; a method for culturing a hematopoietic stem cell, which comprises culturing the hematopoietic stem cell in the presence of the hematopoietic stem cell growth auxiliary agent or in the medium for a hematopoietic stem cell; and a method for treating a blood disease, which comprises transplanting a hematopoietic stem cell cultured by the above method to bone marrow of a mammal.

Abstract translation: 其中构成N-乙酰基鸟嘌呤的N-乙酰葡糖胺的伯羟基被硫酸化的6-O-硫酸化N-乙酰基己二胺; 一种造血干细胞生长辅助剂，具有造血干细胞生长促进活性，并含有6-O-硫酸化N-乙酰肝素作为活性成分; 用于造血干细胞的培养基，其包含造血干细胞生长辅助剂和培养造血干细胞所需的其它培养基; 培养造血干细胞的方法，其包括在造血干细胞生长辅助剂存在下或在用于造血干细胞的培养基中培养造血干细胞; 和一种治疗血液病的方法，其包括将通过上述方法培养的造血干细胞移植到哺乳动物的骨髓中。

公开(公告)号：US20080221062A1

公开(公告)日：2008-09-11

申请号：US10585417

申请日：2005-01-07

Applicant: Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

Inventor： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

IPC: A61K31/726 ,  A61P19/02

CPC classification number: A61K31/196 ,  A61K31/192 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/60 ,  A61K31/728 ,  A61K47/55 ,  A61K47/61

Abstract: A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof.

Abstract translation: 一种透明质酸衍生物及其制备方法，其中抗炎药物通过共价键通过具有可生物降解区域的间隔物与透明质酸结合。

公开(公告)号：US07879817B2

公开(公告)日：2011-02-01

申请号：US10585417

申请日：2005-01-07

Applicant: Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

Inventor： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

IPC: A01N43/04 ,  A61K31/715 ,  A61K31/70 ,  A61P29/00

CPC classification number: A61K31/196 ,  A61K31/192 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/60 ,  A61K31/728 ,  A61K47/55 ,  A61K47/61

Abstract: A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof.

Abstract translation: 一种透明质酸衍生物及其制备方法，其中抗炎药物通过共价键通过具有可生物降解区域的间隔物与透明质酸结合。

公开(公告)号：US20090118348A1

公开(公告)日：2009-05-07

申请号：US11994981

申请日：2006-07-05

Applicant: Kenji Miyamoto ,  Yousuke Yasuda

Inventor： Kenji Miyamoto ,  Yousuke Yasuda

IPC: A61K47/36 ,  A61K31/192 ,  A61K31/407 ,  A61P29/00 ,  A61P19/02

CPC classification number: A61K31/192 ,  A61K9/0024 ,  A61K47/61 ,  A61K47/6903

Abstract: A drug-introduced photo-crosslinked hyaluronic acid derived gel which is a photo-crosslinked hyaluronic acid gel into which a drug is introduced through a covalent bond, and has characteristics that are capable of extruding from an injection device. The drug-introduced photo-cross-linked hyaluronic acid derived gel is capable of extruding, for example, by an injection needle of 20 to 25 gauge with a pressure of 0.5 to 5 kg/cm2.

Abstract translation: 一种药物引入的光交联透明质酸衍生凝胶，其是通过共价键引入药物的光交联透明质酸凝胶，并且具有能够从注射装置挤出的特征。 药物引入的光交联透明质酸衍生的凝胶例如可以通过20至25号的注射针以0.5至5kg / cm2的压力挤出。

公开(公告)号：US08557986B2

公开(公告)日：2013-10-15

申请号：US12299091

申请日：2007-04-27

Applicant: Yousuke Yasuda

Inventor： Yousuke Yasuda

IPC: C07D251/46

CPC classification number: C07D251/46 ,  A61K47/61 ,  C08B37/0072

Abstract: A polysaccharide derivative having a high solubility in an aqueous solvent is produced. The production method of the present invention uses a compound shown by the general formula (1) as a condensing agent and allows a polysaccharide having a carboxyl group to react with an an organic compound having a functional group capable of condensing with the carboxyl group to prepare the polysaccharide derivative: R1 and R2 independently represent a substituent selected among alkyl groups of 1 to 4 carbon atoms and aryl groups of 6 to 8 carbon atoms; Z−represents a counter anion; and E+represents an organic group shown as: R3, R4, and R5 independently represent an organic group having at least one carbon atom directly bound to a quaternary nitrogen atom and any two or all of R3, R4, and R5 may link together to form a cyclic structure.

Abstract translation: 制备在水性溶剂中具有高溶解度的多糖衍生物。 本发明的制造方法使用通式（1）所示的化合物作为缩合剂，使具有羧基的多糖与具有能够与羧基缩合的官能团的有机化合物反应，制备 多糖衍生物：R1和R2独立地表示选自1至4个碳原子的烷基和6至8个碳原子的芳基的取代基; Z-表示抗衡阴离子; 并且E +表示如下所示的有机基团：R 3，R 4和R 5独立地表示具有至少一个碳原子与季氮原子结合的有机基团，并且R 3，R 4和R 5中的任何两个或全部可以连接至 形成循环结构。

公开(公告)号：US08354392B2

公开(公告)日：2013-01-15

申请号：US11994981

申请日：2006-07-05

Applicant: Kenji Miyamoto ,  Yousuke Yasuda

Inventor： Kenji Miyamoto ,  Yousuke Yasuda

IPC: A61K31/728 ,  C07H5/06

CPC classification number: A61K31/192 ,  A61K9/0024 ,  A61K47/61 ,  A61K47/6903

Abstract: A drug-introduced photo-crosslinked hyaluronic acid derived gel which is a photo-crosslinked hyaluronic acid gel into which a drug is introduced through a covalent bond, and has characteristics that are capable of extruding from an injection device. The drug-introduced photo-cross-linked hyaluronic acid derived gel is capable of extruding, for example, by an injection needle of 20 to 25 gauge with a pressure of 0.5 to 5 kg/cm2.

Abstract translation: 一种药物引入的光交联透明质酸衍生凝胶，其是通过共价键引入药物的光交联透明质酸凝胶，并且具有能够从注射装置挤出的特征。 药物引入的光交联透明质酸衍生的凝胶例如可以通过20至25号的注射针以0.5至5kg / cm2的压力挤出。

公开(公告)号：US20090104678A1

公开(公告)日：2009-04-23

申请号：US12299091

申请日：2007-04-27

Applicant: Yousuke Yasuda

Inventor： Yousuke Yasuda

IPC: C08B37/00 ,  C07K1/00 ,  C12N9/96

CPC classification number: C07D251/46 ,  A61K47/61 ,  C08B37/0072

Abstract: A polysaccharide derivative having a high solubility in an aqueous solvent is produced. The production method of the present invention uses a compound shown by the general formula (1) as a condensing agent and allows a polysaccharide having a carboxyl group to react with an an organic compound having a functional group capable of condensing with the carboxyl group to prepare the polysaccharide derivative: R1 and R2 independently represent a substituent selected among alkyl groups of 1 to 4 carbon atoms and aryl groups of 6 to 8 carbon atoms; Z−represents a counter anion; and E+represents an organic group shown as: R3, R4, and R5 independently represent an organic group having at least one carbon atom directly bound to a quaternary nitrogen atom and any two or all of R3, R4, and R5 may link together to form a cyclic structure.

Abstract translation: 制备在水性溶剂中具有高溶解度的多糖衍生物。 本发明的制造方法使用通式（1）所示的化合物作为缩合剂，使具有羧基的多糖与具有能够与羧基缩合的官能团的有机化合物反应，制备 多糖衍生物：R1和R2独立地表示选自1至4个碳原子的烷基和6至8个碳原子的芳基的取代基; Z-表示抗衡阴离子; 并且E +表示如下所示的有机基团：R 3，R 4和R 5独立地表示具有至少一个碳原子与季氮原子结合的有机基团，并且R 3，R 4和R 5中的任何两个或全部可以连接至 形成循环结构。

公开(公告)号：US06562954B1

公开(公告)日：2003-05-13

申请号：US09478025

申请日：2000-01-05

Applicant: Yuji Matsuzaki ,  Yousuke Yasuda ,  Satoshi Miyauchi ,  Junichi Onaya ,  Yusuke Hori ,  Akira Tawada ,  Hideo Mochizuki ,  Masami Iida

Inventor： Yuji Matsuzaki ,  Yousuke Yasuda ,  Satoshi Miyauchi ,  Junichi Onaya ,  Yusuke Hori ,  Akira Tawada ,  Hideo Mochizuki ,  Masami Iida

IPC: C07H1702

CPC classification number: C07H11/00 ,  Y02P20/55

Abstract: Oligosaccharides including those usable as anti-inflammatory agent or anti-allergy agent, represented by the following general formula (3): wherein R10 and R11 each independently represent a hydrogen atom or —SO3M where M represents a proton or a monovalent cation, Ac represents an acetyl group, R12 represents a hydrogen atom or an anomeric substituent (a 6-O-sulfated N-acetylglucosamine residue, an alkyl group, a glycerol residue, an O-alkylglycerol residue, a cholesterol residue, a cholestanyl group, a ceramide residue, a phospholipid residue, a biotin residue, or a peptide residue), and Z represents an oxygen atom or —NHCO—.

Abstract translation: 包括可用作抗炎剂或抗过敏剂的寡糖，由以下通式（3）表示：其中R10和R11各自独立地表示氢原子或-SO3M，其中M表示质子或一价阳离子，Ac表示 乙酰基，R 12表示氢原子或端基异构取代基（6-O-硫酸化N-乙酰葡糖胺残基，烷基，甘油残基，O-烷基甘油残基，胆固醇残基，胆甾烷基，神经酰胺残基 ，磷脂残基，生物素残基或肽残基），Z表示氧原子或-NHCO-。