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    Process for producing acrylic ester compound
    92.
    发明授权
    Process for producing acrylic ester compound 有权
    制备丙烯酸酯化合物的方法

    公开(公告)号：US07173147B2

    公开(公告)日：2007-02-06

    申请号：US10995334

    申请日：2004-11-24

    申请人： Satoru Miyazawa ,  Yusuke Kuramoto ,  Satoru Kobayashi ,  Kazuhiko Maeda

    发明人： Satoru Miyazawa ,  Yusuke Kuramoto ,  Satoru Kobayashi ,  Kazuhiko Maeda

    IPC分类号： C07C233/00

    CPC分类号： C07C67/14 ,  C07C69/653

    摘要： A process for producing an acrylic ester compound includes reacting in the presence of alkene an alcohol represented by the formula (1), wherein R1 represents a hydrogen atom, a fluorine atom, a straight-chain or branched hydrocarbon group, a fluorine-containing alkyl group, or an aromatic or aliphatic ring and optionally contains oxygen, sulfur or a carbonyl bond, with an acid halide represented by the formula (2), wherein R2 represents a hydrogen atom, a halogen atom, a hydrocarbon group, or a fluorine-containing alkyl group, and X represents a halogen atom.

    摘要翻译： 丙烯酸酯化合物的制造方法包括在烯烃存在下使式（1）表示的醇反应，其中R 1表示氢原子，氟原子，直链或支链 烃基，含氟烷基或芳族或脂族环，并且任选地含有氧，硫或羰基键，与式（2）表示的酰基卤，其中R 2表示 氢原子，卤素原子，烃基或含氟烷基，X表示卤素原子。

    Transfection reagents
    93.
    发明授权
    Transfection reagents 有权

    公开(公告)号：US07166745B1

    公开(公告)日：2007-01-23

    申请号：US09438365

    申请日：1999-11-12

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00 ,  C07C277/00

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L′—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and any one of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C(NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and t are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Composition for external application
    95.
    发明授权
    Composition for external application 有权
    组合外部应用

    公开(公告)号：US07087646B2

    公开(公告)日：2006-08-08

    申请号：US10082115

    申请日：2002-02-26

    申请人： Masahide Hoshino ,  Hiroaki Saito ,  Yoshiya Sugai ,  Mituru Sugiyama ,  Yoshinori Nishizawa ,  Yasushi Katayama

    发明人： Masahide Hoshino ,  Hiroaki Saito ,  Yoshiya Sugai ,  Mituru Sugiyama ,  Yoshinori Nishizawa ,  Yasushi Katayama

    IPC分类号： A01N37/18 ,  A61K6/00 ,  C07C233/00

    CPC分类号： A61Q5/00 ,  A61K8/42 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007

    摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

    摘要翻译： 本发明涉及外用的组合物，保湿剂和皮肤屏障功能增强剂，其各自含有下式（1）表示的二酰胺衍生物：（其中，R 1a和R“ SUP> 1b相同或不同，分别表示C 1-13烃基，R 2a和R 2b均为 相同或不同，并且各自表示二价C 1-6 - 烃基，R 3相同或不同，并且各自表示二价C 2-6 烃基，n表示1〜100）。 外用组合物，保湿剂和皮肤屏障功能增强剂基本上提高了角质层的保水能力和阻隔功能，具有优异的混溶性和混合稳定性，可以以低成本高效制备。

    Antibiotic compounds
    100.
    发明申请
    Antibiotic compounds 失效
    抗生素化合物

    公开(公告)号：US20050209212A1

    公开(公告)日：2005-09-22

    申请号：US11126331

    申请日：2005-05-11

    申请人： Michael Betts ,  Gareth Davies ,  Michael Swain

    发明人： Michael Betts ,  Gareth Davies ,  Michael Swain

    IPC分类号： A61K31/397 ,  A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  A61K38/40 ,  A61P31/04 ,  C07C233/00 ,  C07D205/00 ,  C07D207/00 ,  C07D207/16 ,  C07D403/12 ,  C07D477/00 ,  C07D477/20 ,  C07D487/04 ,  C07F9/568 ,  C07F9/572 ,  C07F9/6574

    CPC分类号： C07D477/20 ,  A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  C07D207/16 ,  C07D403/12 ,  C07F9/568

    摘要： The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl, di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alkylamino, di-C1-4alkylamino, C1-4alkanoylamino, C1-4alkanoyl(N—C1-4alkyl)amino, C1-4alkanesulphonamido and C1-4alkylS(O)n— wherein n is zero; one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to —NR3—. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及碳青霉烯并提供式（I）化合物或其药学上可接受的盐或体内可水解的酯，其中：R 1是1-羟基乙基，1-氟乙基或羟甲基; R 2是氢或C 1-4烷基; R 3是氢或C 1-4烷基; R 4和R 5相同或不同，并且选自氢，卤素，氰基，C 1-4烷基，硝基，羟基 ，羧基，C 1-4烷氧基，C 1-4烷氧基羰基，氨基磺酰基，C 1-4烷基氨基磺酰基，二-C 1-4烷基氨基磺酰基，氨基甲酰基，C 1-4烷基氨基甲酰基，二-C 1-4烷基氨基甲酰基，三氟甲基，磺酸，氨基，C NC 1-4烷基）氨基，C 1-4烷基磺酰氨基和C 1-4烷基S（ O）n - 其中n为零; 一个或两个：条件是在与-NR 3 - 连接的邻位的位置上不存在羟基或羧基取代基。 其制备方法，制备中的中间体，其作为治疗剂的用途和含有它们的药物组合物。