公开(公告)号：US20050209212A1

公开(公告)日：2005-09-22

申请号：US11126331

申请日：2005-05-11

申请人： Michael Betts ,  Gareth Davies ,  Michael Swain

发明人： Michael Betts ,  Gareth Davies ,  Michael Swain

IPC分类号： A61K31/397 ,  A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  A61K38/40 ,  A61P31/04 ,  C07C233/00 ,  C07D205/00 ,  C07D207/00 ,  C07D207/16 ,  C07D403/12 ,  C07D477/00 ,  C07D477/20 ,  C07D487/04 ,  C07F9/568 ,  C07F9/572 ,  C07F9/6574

CPC分类号： C07D477/20 ,  A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  C07D207/16 ,  C07D403/12 ,  C07F9/568

摘要： The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl, di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alkylamino, di-C1-4alkylamino, C1-4alkanoylamino, C1-4alkanoyl(N—C1-4alkyl)amino, C1-4alkanesulphonamido and C1-4alkylS(O)n— wherein n is zero; one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to —NR3—. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及碳青霉烯并提供式（I）化合物或其药学上可接受的盐或体内可水解的酯，其中：R 1是1-羟基乙基，1-氟乙基或羟甲基; R 2是氢或C 1-4烷基; R 3是氢或C 1-4烷基; R 4和R 5相同或不同，并且选自氢，卤素，氰基，C 1-4烷基，硝基，羟基 ，羧基，C 1-4烷氧基，C 1-4烷氧基羰基，氨基磺酰基，C 1-4烷基氨基磺酰基，二-C 1-4烷基氨基磺酰基，氨基甲酰基，C 1-4烷基氨基甲酰基，二-C 1-4烷基氨基甲酰基，三氟甲基，磺酸，氨基，C _{NC 1-4烷基）氨基，C 1-4烷基磺酰氨基和C 1-4烷基S（ O）n - 其中n为零; 一个或两个：条件是在与-NR 3 - 连接的邻位的位置上不存在羟基或羧基取代基。 其制备方法，制备中的中间体，其作为治疗剂的用途和含有它们的药物组合物。}

公开(公告)号：US20050032861A1

公开(公告)日：2005-02-10

申请号：US10480959

申请日：2002-04-03

申请人： Michael Betts ,  Michael Swain ,  Neil Hales ,  Hoan Huynh

发明人： Michael Betts ,  Michael Swain ,  Neil Hales ,  Hoan Huynh

IPC分类号： C07D413/06 ,  A61K31/422 ,  A61K31/427 ,  A61K31/541 ,  A61P31/04 ,  C07D413/14 ,  C07D417/14 ,  C07D413/02

CPC分类号： C07D413/14 ,  C07D417/14

摘要： Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, or an N-linked 6-membered di-hydro-heteroaryl ring; and Q is, for example, Q1 or Q2: wherein R2 and R3 are independently hydrogen or fluoro; T is selected, for example, from a group of the formula (TA1) or (TA2): wherein, for example, X1m is O═ and X2m is R2s—(E)ms—N—; wherein E is an electron withdrawing group, for example, —SO2— or —CO—; and, for example, R2s is hydrogen or (1-6C)alkyl; are useful as pharmaceutical agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

摘要翻译： 式（I）化合物或其药学上可接受的盐或其体内可水解的酯，其中例如HET是N-连接的5元全部或部分不饱和的杂环或N 连接的6元二氢杂芳基环; Q为例如Q1或Q2：其中R 2和R 3独立地为氢或氟; T选自例如式（TA1）或（TA2）的基团：其中，例如，X1m为O =，X2m为R2s-（E）ms-N-; 其中E是吸电子基团，例如-SO 2 - 或-CO-; 并且例如，R 2是氢或（1-6C）烷基; 作为药剂有用; 并描述了其制造方法和含有它们的药物组合物。

公开(公告)号：US20070281916A1

公开(公告)日：2007-12-06

申请号：US11238260

申请日：2005-09-29

申请人： Michael Gravestock ,  Michael Betts

发明人： Michael Gravestock ,  Michael Betts

IPC分类号： A61K31/496 ,  A61K31/4439 ,  C07D413/14

CPC分类号： C07D413/14 ,  C07D261/08 ,  C07D261/12 ,  C07D261/14

摘要： Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, R13CO—, R13SO2— or R13CS—; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

摘要翻译： 式（I）化合物或其药学上可接受的盐或其体内可水解的酯，其中例如X是O，S或NH; HET是含有2至4个独立地选自N，O和S的杂原子的任选取代的C连接的5元杂芳基环; Q选自例如Q1和Q2：R 2和R 3独立地是氢或氟; T选自一组范围，例如，N-连接的（完全不饱和的）5元杂芳基环系或式（TC5）的基团：其中Rc是例如R 13 CO-，R 13 SO 2 - 或R 13 CS-; 其中R 13是例如任选取代的（1-10C）烷基或R 14 C（O）O（1-6C）烷基，其中R 0 > 14是任选取代的（1-10C）烷基; 作为抗菌剂是有用的; 并描述了其制造方法和含有它们的药物组合物。

公开(公告)号：US20080126514A1

公开(公告)日：2008-05-29

申请号：US11771319

申请日：2007-06-29

申请人： Michael Betts

发明人： Michael Betts

IPC分类号： G06F15/16

CPC分类号： G06T1/00

摘要： A system and method for creating an image object or set from a plurality of captured images. The system comprises an interface for receiving the captured images from a client location, a storage device for storing the images and a processor for converting the received images into a format compatible with the image object. The system may include a user interface for accessing the image object and manipulating or otherwise managing the image object (or image set). According to one embodiment, the system comprises a network-based implementation, such as a web-based implementation for the Internet.

摘要翻译： 一种用于从多个捕获图像创建图像对象或集合的系统和方法。 该系统包括用于从客户端位置接收捕获的图像的接口，用于存储图像的存储装置和用于将接收到的图像转换成与图像对象兼容的格式的处理器。 系统可以包括用于访问图像对象并操纵或以其他方式管理图像对象（或图像集合）的用户界面。 根据一个实施例，该系统包括基于网络的实现，诸如用于因特网的基于web的实现。

公开(公告)号：US20060035895A1

公开(公告)日：2006-02-16

申请号：US11238709

申请日：2005-09-29

申请人： Michael Betts

发明人： Michael Betts

IPC分类号： A61K31/5377 ,  A61K31/42 ,  C07D413/02

CPC分类号： C07D413/06 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, or HET is an N-linked 6-membered di-hydro-heteroaryl ring; Q is, for example, Q1 or Q2: wherein R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example a group of the formula (TC7) wherein Rc is, for example, hydrogen, R13CO—, R13SO2— or R13CS—; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

摘要翻译： 式（I）化合物或其药学上可接受的盐或其体内可水解的酯，其中例如HET是N-连接的5元全部或部分不饱和杂环，或HET是 N-连接的6-元二氢杂芳基环; Q是例如Q1或Q2：其中R 2和R 3独立地是氢或氟; T选自一组范围，例如其中R c为例如式（TC7）的基团，R 13为CO，R 13 SO 2 - 或 - R 13 CS-; 其中R 13为例如任选取代的（1-10C）烷基或R 14 C（O）O（1-6C）烷基，其中R 14 任选取代的（1-10C）烷基; 作为抗菌剂是有用的; 并描述了其制造方法和含有它们的药物组合物。

公开(公告)号：US20050161261A1

公开(公告)日：2005-07-28

申请号：US10506829

申请日：2003-03-07

申请人： Michael Betts ,  Josef Guillaume Coenen ,  Pieter Kapteijn ,  Peter Oosterling ,  Paul Schilte ,  Pleun Van Der Sman ,  Gustaaf Van Wechem

发明人： Michael Betts ,  Josef Guillaume Coenen ,  Pieter Kapteijn ,  Peter Oosterling ,  Paul Schilte ,  Pleun Van Der Sman ,  Gustaaf Van Wechem

IPC分类号： E21B7/06 ,  E21B7/20 ,  E21B7/26 ,  E21B7/30 ,  E21B17/20 ,  E21B7/04

CPC分类号： E21B7/30 ,  E21B7/067 ,  E21B7/20 ,  E21B7/26 ,  E21B17/20

摘要： A steerable soil penetration system having a steerable penetration head, which compacts and does not cut away the surrounding soil and which is connected to an elongate flexible tubing such that the orientation of the penetration head can be varied relative to the tubing. The elongate tubing and/or a downhole hammer or tractor pushes the penetration head through the subsurface formation. Preferably the tubing is surrounded by a narrow annulus so that buckling of the tubing is inhibited and the tubing protects the pierced hole against caving in. Optionally the tubing is circumferentially expanded after completion of the piercing process thereby increasing the width of the pierced hole and providing a permanent hole lining

摘要翻译： 可操纵的土壤穿透系统，其具有可转向的穿透头，其压紧并且不切除周围的土壤并且连接到细长的柔性管，使得穿透头的取向可以相对于管变化。 细长管和/或井下锤或拖拉机将穿透头推动通过地下地层。 优选地，管道被狭窄的环带包围，使得管道的弯曲被抑制，并且管道保护穿孔以防止塌陷。可选地，在穿孔过程完成之后，管道被周向地膨胀，从而增加穿孔的宽度并提供 永久性孔衬

公开(公告)号：US20050119317A1

公开(公告)日：2005-06-02

申请号：US10493707

申请日：2002-10-23

申请人： Michael Betts

发明人： Michael Betts

IPC分类号： A61K31/422 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/54 ,  A61P31/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/42 ,  A61K31/427 ,  C07D413/02

CPC分类号： C07D413/06 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, or HET is an N-linked 6-membered di-hydro-heteroaryl ring; Q is, for example, Q1 or Q2: wherein R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example a group of the formula (TC7) wherein Rc is, for example, hydrogen, R13CO—, R13SO2— or R13CS—; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

摘要翻译： 式（I）化合物或其药学上可接受的盐或其体内可水解的酯，其中例如HET是N-连接的5元全部或部分不饱和杂环，或HET是 N-连接的6-元二氢杂芳基环; Q是例如Q1或Q2：其中R 2和R 3独立地是氢或氟; T选自一组范围，例如其中R c为例如式（TC7）的基团，R 13为CO，R 13 SO 2 - 或 - R 13 CS-; 其中R 13为例如任选取代的（1-10C）烷基或R 14 C（O）O（1-6C）烷基，其中R 14 任选取代的（1-10C）烷基; 作为抗菌剂是有用的; 并描述了其制造方法和含有它们的药物组合物。