公开(公告)号：US07045139B2

公开(公告)日：2006-05-16

申请号：US10682004

申请日：2003-10-08

申请人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Bharat Bhikaji Parab ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

发明人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Bharat Bhikaji Parab ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

IPC分类号： A01N25/08

CPC分类号： A61K31/205 ,  C07C231/12 ,  C07C235/34 ,  C07C237/36

摘要： An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in making fabric care products and personal care products. The scope of this methodology has been demonstrated by converting water soluble organic sunscreen quaternary halides to their corresponding tosylates of Formula VI.

摘要翻译： 已经描述了用于制造肉豆蔻酰烷基胺和/或苯甲酰胺基烷基胺的甲苯磺酸盐季铵盐的有效，简单，高产，环保的方法（式I）。 这些化合物是实质的紫外线吸收剂。 它们可用于制作织物护理产品和个人护理产品。 通过将水溶性有机防晒季铵盐转化成其相应的式VI的甲苯磺酸酯已经证明了该方法的范围。

公开(公告)号：US06426435B1

公开(公告)日：2002-07-30

申请号：US09917953

申请日：2001-07-31

申请人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

发明人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

IPC分类号： C07C23309

CPC分类号： C07C233/40 ,  A61K8/416 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  C11D3/28

摘要： Substantive UV-absorbing water-soluble quaternary salts of cinnamidoalkylamine of formula I. Hair, skin and fabric care compositions containing the compounds of formula I; wherein R1 represents up to four substituents, same or different, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing up to 6 carbon atoms, alkoxy groups containing up to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing up to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing up to 6 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing up to 6 carbon atoms; n is an integer from 1 to 6; m is an integer from 1 to 10; X− is a counter anion of quaternary centres selected from halides including chloride, bromide, iodide and methane sulphonate and its derivatives such as trifluoro methane sulphonate, benzene sulphonates including its p-bromo, nitro and methyl derivative.

摘要翻译： 含有式I的肉桂酰胺基烷基胺的实质性紫外线吸收水溶性季盐。含有式I化合物的头发，皮肤和织物护理组合物;其中R1代表至多四个相同或不同的选自H，卤素，-OH， -NH 2，-NO 2，-OCH 3，-N（CH 3）2，含有至多6个碳原子的烷基，含有至多6个碳原子的烷氧基，含有至多6个碳原子的烷基氨基或N，N-二烷基氨基; R2选自氢，最多含6个碳原子的烷基; R3和R4独立地选自苄基，含有至多6个碳原子的烷基; n是1至6的整数; m为1〜10的整数; X-是选自卤化物（包括氯化物，溴化物，碘化物和甲磺酸盐）及其衍生物如三氟甲烷磺酸盐，苯磺酸盐，包括其对溴，硝基和甲基衍生物的季铵盐的抗衡阴离子。

公开(公告)号：US07205436B2

公开(公告)日：2007-04-17

申请号：US11128980

申请日：2005-05-13

申请人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Bharat Bhikaji Parab ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

发明人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Bharat Bhikaji Parab ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

IPC分类号： C07C233/00

CPC分类号： A61K31/205 ,  C07C231/12 ,  C07C235/34 ,  C07C237/36

摘要： An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in making fabric care products and personal care products. The scope of this methodology has been demonstrated by converting water soluble organic sunscreen quaternary halides to their corresponding tosylates of Formula VI.

摘要翻译： 已经描述了用于制造肉豆蔻酰烷基胺和/或苯甲酰胺基烷基胺的甲苯磺酸盐季铵盐的有效，简单，高产，环保的方法（式I）。 这些化合物是实质的紫外线吸收剂。 它们可用于制作织物护理产品和个人护理产品。

公开(公告)号：US20110263901A1

公开(公告)日：2011-10-27

申请号：US12525587

申请日：2009-01-13

申请人： Dhananjay Govind Sathe ,  Harish Kashinath Mondkar ,  Tanaji Shamrao Jadhav ,  Nitin Nivrutti Hagavane

发明人： Dhananjay Govind Sathe ,  Harish Kashinath Mondkar ,  Tanaji Shamrao Jadhav ,  Nitin Nivrutti Hagavane

IPC分类号： C07C279/26 ,  C07C277/06 ,  C07C277/08

CPC分类号： C07C279/26

摘要： Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5-isopropyl-biguanide hydrochloride (Proguanil hydrochloride), Formula-I, an antimalarial agent.

摘要翻译： 本文公开了制备1-（4-氯苯基）-5-异丙基 - 双胍盐酸盐（盐酸氯胍），式I，抗疟药剂的方法。

公开(公告)号：US20100331516A1

公开(公告)日：2010-12-30

申请号：US12525863

申请日：2009-04-06

申请人： Govind Dhananjay Sathe ,  Harish Kashinath Mondkar ,  Tanaji Shamrao Jadhav ,  Samadhan Daulat Patil

发明人： Govind Dhananjay Sathe ,  Harish Kashinath Mondkar ,  Tanaji Shamrao Jadhav ,  Samadhan Daulat Patil

IPC分类号： C08G65/02

CPC分类号： A61K31/785 ,  C08F8/00 ,  C08F8/18 ,  C08F2810/20 ,  C08F26/02 ,  C08F126/06

摘要： The present invention discloses simple process for preparation of salt of polyallylamine polymer.

摘要翻译： 本发明公开了制备聚烯丙基胺聚合物盐的简单方法。

公开(公告)号：US20110159087A1

公开(公告)日：2011-06-30

申请号：US13060624

申请日：2009-09-02

申请人： Dhananjay Govind Sathe ,  Harish Kashinath Mondkar ,  Mantripragada Narayan Rao ,  Samadhan Daulat Patil ,  Tanaji Shamrao Jadhav ,  Ashok Omray ,  Varsha Shashank Choudhary ,  Yogesh Sharad Bhide

发明人： Dhananjay Govind Sathe ,  Harish Kashinath Mondkar ,  Mantripragada Narayan Rao ,  Samadhan Daulat Patil ,  Tanaji Shamrao Jadhav ,  Ashok Omray ,  Varsha Shashank Choudhary ,  Yogesh Sharad Bhide

IPC分类号： A61K9/48 ,  A61K31/785 ,  A61K9/14 ,  A61K9/20 ,  C08G73/02 ,  A61P3/00 ,  B02C23/18 ,  B32B5/00 ,  A61K9/28 ,  B29C43/02 ,  B65B1/20

CPC分类号： A61K31/785 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2866 ,  Y10T428/2982

摘要： Disclosed herein are pharmaceutical compositions comprising wet granulated bile acid sequestrants having the general Formula I shown, and their process of preparation. The present invention also discloses process for preparation of Colesevelam hydrochloride, an antilipemic agent.

摘要翻译： 本文公开了包含具有所示通式I的湿法制粒胆固醇螯合剂及其制备方法的药物组合物。 本发明还公开了制备盐酸考利司他的方法，其是抗血药剂。

公开(公告)号：US07147866B2

公开(公告)日：2006-12-12

申请号：US10953832

申请日：2004-09-29

申请人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Tanaji Shamrao Jadhav

发明人： Nirmal Madhukar Koshti ,  Shubhangi Dattaram Naik ,  Tanaji Shamrao Jadhav

IPC分类号： A61K9/127 ,  C07C233/00 ,  A61K31/165

CPC分类号： A61Q5/12 ,  A61K8/14 ,  A61K8/42 ,  A61K8/466 ,  A61Q17/04

摘要： Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher levels of photoprotection to skin and hair. The vesicular compositions of the present invention are made from cationic UV-absorbing lipids of Formula I wherein, ArCO is selected from cinnamoyl, p-methoxy cinnamoyl, p-N,N-dimethylamino benzoyl and combinations thereof, R1 is selected from saturated or unsaturated alkyl group with carbons ranging from C10 to C22.

摘要翻译： 在本发明中描述了来自UV吸收型脂质的高效囊泡组合物。 紫外线吸收性能和水泡传播系统的组合导致对皮肤和头发的更高水平的光保护。 本发明的囊状组合物由式I的阳离子紫外线吸收脂质制成，其中ArCO选自肉桂酰，对甲氧基肉桂酰，pN，N-二甲基氨基苯甲酰及其组合，R 1， 选自饱和或不饱和的烷基，碳原子范围为C 10〜C 22。

公开(公告)号：US06613340B2

公开(公告)日：2003-09-02

申请号：US09917726

申请日：2001-07-31

申请人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

发明人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

IPC分类号： A61K742

CPC分类号： A61K8/466 ,  A61K8/42 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/10 ,  C07C235/34 ,  C07C309/30 ,  C11D1/62

摘要： Substantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula I. wherein R1 is a substituent, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms; n is an integer from 1 to 6; R5 is selected from an alkyl group containing from 8 to 22 carbon atoms; alkenyl groups containing from 8 to 22 carbon atoms; R7 is selected from bromo, chloro, nitro, methyl and ethyl groups.

摘要翻译： 描述肉桂酰胺基胺的实质性UV吸收有机溶性季盐。 含有式I化合物的头发，皮肤和织物护理组合物，其中R1是选自H，卤素，-OH，-NH2，-NO2，-OCH3，-N（CH3）2，含1〜 6个碳原子，含有1至6个碳原子的烷氧基，含有1至6个碳原子的烷基氨基或N，N-二烷基氨基; R2选自氢，含1至12个碳原子的烷基; R 3和R 4独立地选自苄基，含有1至12个碳原子的烷基; n是1至6的整数; R5选自含有8-22个碳原子的烷基; 含有8-22个碳原子的烯基; R 7选自溴，氯，硝基，甲基和乙基。

公开(公告)号：US06531628B1

公开(公告)日：2003-03-11

申请号：US10104162

申请日：2002-03-22

申请人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

发明人： Nirmal Madhukar Koshti ,  Arun Harchandra Jawale ,  Bharat Bhikaji Parab ,  Shubhangi Dattaram Naik ,  Manasi Dattatraya Moghe ,  Tanaji Shamrao Jadhav ,  Subhash Shivling Nashte

IPC分类号： C07C30914

CPC分类号： C07C309/14

摘要： Substantive UV-absorbing water-soluble 2-hydroxy sulfobetaine of cinnamidoalkylamines of Formula I. Hair, skin and fabric care compositions containing the compounds of Formula I. wherein, R1 is a substituent, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms, n is an integer from 1 to 6.

摘要翻译： 含有式I的化合物的头发，皮肤和织物护理组合物，其中R 1是选自H，卤素，-OH，-NH 2，C 1 -C 6烷基的取代基， -NO 2，-OCH 3，-N（CH 3）2，含有1至6个碳原子的烷基，含有1至6个碳原子的烷氧基，含有1至6个碳原子的烷基氨基或N，N-二烷基氨基; R 2 选自氢，含有1至12个碳原子的烷基; R 3和R 4独立地选自苄基，含有1至12个碳原子的烷基，n为1至6的整数。