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公开(公告)号：US20190201684A1
公开(公告)日：2019-07-04
申请号：US16326824
申请日：2017-08-25
Applicant: Wisconsin Alumni Research Foundation , Mayo Foundation for Medical Education and Research
Inventor： Justin Williams , Kip Ludwig , Erika Ross
CPC classification number: A61N1/056 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/0536 , A61N1/0551 , A61N1/36025 , A61N1/36034 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36132 , A61N1/36146 , A61N1/36175 , A61N1/37516
Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.
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公开(公告)号：US20180333575A1
公开(公告)日：2018-11-22
申请号：US15578756
申请日：2016-06-02
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton
IPC: A61N1/36 , A61B5/048 , A61N1/02 , A61B5/0478 , A61B5/16 , A61B5/00 , A61N1/04 , A61B3/113 , A61B3/14 , A61B5/04 , A61N1/20 , A63F13/212
CPC classification number: A61N1/36003 , A61B3/113 , A61B3/14 , A61B5/04001 , A61B5/0478 , A61B5/048 , A61B5/0482 , A61B5/11 , A61B5/1124 , A61B5/165 , A61B5/168 , A61B5/4064 , A61B5/4836 , A61B5/486 , A61B5/6803 , A61B5/686 , A61B5/7203 , A61B5/7217 , A61B5/726 , A61B5/7405 , A61B5/742 , A61B2505/09 , A61B2560/0223 , A61N1/025 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/20 , A61N1/36031 , A61N1/36103 , A63F13/212 , G06F3/015
Abstract: The following relates generally to systems, methods and devices for rehabilitation of patients with motor impairment. Electrical signals of a patient may be sensed using electrodes. From the electrical signals, an intent to move or focus level may be determined. Based on the electrical signals, neuromuscular stimulation is delivered to the patient. The stimulation may be delivered through a neuromuscular stimulation sleeve.
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公开(公告)号：US20180296832A1
公开(公告)日：2018-10-18
申请号：US15992780
申请日：2018-05-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Harrison W. Lin , Hamid Djalilian , Ronald Sahyouni
IPC: A61N1/36 , A61N1/05 , A61N1/04 , A61B5/0492 , A61N1/02
CPC classification number: A61N1/36003 , A61B5/0492 , A61B5/1107 , A61B5/4836 , A61B5/6814 , A61N1/025 , A61N1/0452 , A61N1/0456 , A61N1/0556 , A61N1/36038 , A61N1/36067 , A61N1/36103 , A61N1/36139
Abstract: Disclosed herein is a method of treating a disease, comprising: (a) implanting an array of electrodes on one or more targeted nerves and/or targeted muscles; and (b) treating the disease by selectively stimulating the one or more targeted nerves and/or targeted muscles through electrical pulses delivered from the array. Also disclosed herein is a device, comprising a plurality of electrodes that have the capacity to be inserted in or around a facial nerve. Further disclosed herein is a method of treating facial paralysis and/or damage in a subject, comprising: (a) detecting the level of contraction of individual muscles on a healthy, non-paralyzed side of the face of the subject; and (b) treating facial paralysis by a direct targeted stimulation of the corresponding muscles or nerve fibers on a paralyzed side of the face of the subject. Also disclosed herein is a method of treating synkinesis, comprising: (a) implanting an array of electrodes on one or more targeted nerves and/or targeted muscles; and (b) selectively suppressing the one or more targeted nerves and/or targeted muscles through electrical pulses delivered from the array.
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公开(公告)号：US09981128B2
公开(公告)日：2018-05-29
申请号：US15695816
申请日：2017-09-05
Applicant: Halo Neuro, Inc.
Inventor： Brett Wingeier
IPC: A61N1/05 , A61N1/36 , A61B5/16 , A61B5/00 , A61N1/04 , A61B5/0205 , A61B5/0496 , A61B5/0488 , A61B5/0476
CPC classification number: A61N1/36025 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/16 , A61B5/4064 , A61B5/4076 , A61B5/4836 , A61N1/0456 , A61N1/0526 , A61N1/36082 , A61N1/36103
Abstract: A method for providing electrical stimulation to a user, the method comprising: providing an electrical stimulation device, in communication with a controller, at a head region of the user; with the electrical stimulation device, providing a stimulation treatment having a waveform configured for neuromodulation in the user; with the controller, performing an adjustment to the stimulation treatment, wherein performing the adjustment includes: generating a transformed waveform with application of a transfer function to the waveform, wherein the transfer function scales the waveform and selectively attenuates extreme waveform values while maintaining a frequency characteristic of the waveform in the transformed waveform; and applying the transformed waveform with the electrical stimulation device, thereby modulating the stimulation treatment.
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95.发明授权公开(公告)号：US09931508B2
公开(公告)日：2018-04-03
申请号：US15199580
申请日：2016-06-30
Applicant: California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
Inventor： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangsheng Chen
CPC classification number: A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.
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Patent Agency Ranking
公开(公告)号：US20180064931A1
公开(公告)日：2018-03-08
申请号：US15697358
申请日：2017-09-06
Applicant: Axion BioSystems, Inc. , Virginia Commonwealth University
Inventor： Isaac Perry Clements , Andrew Willsie , James David Ross , Alex Weidenbach , Jonathan Isaacs
CPC classification number: A61N1/0556 , A61B5/04001 , A61B5/6877 , A61B5/6882 , A61N1/0558 , A61N1/36103
Abstract: An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.
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公开(公告)号：US20170319852A1
公开(公告)日：2017-11-09
申请号：US15657915
申请日：2017-07-24
Applicant: Halo Neuro, Inc.
Inventor： Brett Wingeier , Daniel S. Chao , Lee Von Kraus , Amol Sarva , Sophia Sanchez
IPC: A61N1/36 , A61B5/00 , A61B5/04 , A61B5/16 , A61B5/0205 , A61N1/04 , A61N1/08 , A61N2/00 , A61B5/0496 , A61B5/053 , A61B5/0476 , A61N1/05 , A61B5/0488
CPC classification number: A61N1/36025 , A61B5/0205 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0533 , A61B5/16 , A61B5/4064 , A61B5/4076 , A61B5/4836 , A61N1/0456 , A61N1/0526 , A61N1/08 , A61N1/36082 , A61N1/36103 , A61N2/006
Abstract: A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.
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公开(公告)号：US09808641B2
公开(公告)日：2017-11-07
申请号：US14916011
申请日：2014-09-05
Applicant: EBS TECHNOLOGIES GMBH
Inventor： Ingo Wundrich , Udo Warschewske
CPC classification number: A61N2/002 , A61N1/0456 , A61N1/0484 , A61N1/323 , A61N1/36014 , A61N1/36025 , A61N1/36046 , A61N1/36103 , A61N2/006 , A61N2/02
Abstract: The invention relates to a system for electrical and/or magnetic neuronal stimulation, comprising a signal generator for generating a stimulation signal, in particular an alternating-current stimulation signal, an applicator for applying the stimulation signal, in particular in an area on or directly around the optic nerve, a lead for deriving a measurement signal, in particular an EEG signal, a biomarker calculation unit for calculating a biomarker based on the measurement signal, and an optimization unit, in particular for performing a stochastic optimization process, for optimizing the value of the biomarker by varying the stimulation signal.
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公开(公告)号：US20170312493A1
公开(公告)日：2017-11-02
申请号：US15652687
申请日：2017-07-18
Applicant: Duncan Bain , Arthur Tucker , Bernard Ross
Inventor： Duncan Bain , Arthur Tucker , Bernard Ross
CPC classification number: A61N1/0452 , A61N1/205 , A61N1/36003 , A61N1/36014 , A61N1/36067 , A61N1/36103 , A61N1/39
Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.
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公开(公告)号：US09782585B2
公开(公告)日：2017-10-10
申请号：US15059095
申请日：2016-03-02
Applicant: Halo Neuro, Inc.
Inventor： Brett Wingeier
IPC: A61N1/05 , A61N1/36 , A61B5/16 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/00 , A61N1/04
CPC classification number: A61N1/36025 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/16 , A61B5/4064 , A61B5/4076 , A61B5/4836 , A61N1/0456 , A61N1/0526 , A61N1/36082 , A61N1/36103
Abstract: A method for providing electrical stimulation to a user, the method comprising: providing an electrical stimulation device, in communication with a controller, at a head region of the user; with the electrical stimulation device, providing a stimulation treatment having a waveform configured for neuromodulation in the user; with the controller, performing an adjustment to the stimulation treatment, wherein performing the adjustment includes: generating a transformed waveform with application of a transfer function to the waveform, wherein the transfer function scales the waveform and selectively attenuates extreme waveform values while maintaining a frequency characteristic of the waveform in the transformed waveform; and applying the transformed waveform with the electrical stimulation device, thereby modulating the stimulation treatment.
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