公开(公告)号：US20160043074A1

公开(公告)日：2016-02-11

申请号：US14782570

申请日：2014-04-07

Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Inventor： Paul HURLEY ,  Karim CHERKAOUI ,  Vladimir DJARA

IPC: H01L27/06 ,  H01L21/84 ,  H01L29/16 ,  H01L27/12 ,  H01L29/06 ,  H01L29/20 ,  H01L21/8258 ,  H01L27/092

CPC classification number: H01L27/0688 ,  H01L21/8252 ,  H01L21/8258 ,  H01L21/84 ,  H01L27/0605 ,  H01L27/092 ,  H01L27/1203 ,  H01L29/0673 ,  H01L29/16 ,  H01L29/20

Abstract: The invention provides a three dimensional (3D) semi-conductor device comprising a first junctionless transistor doped with dopants of the same polarity; a second junctionless transistor doped with dopants of the same polarity; and the second junctionless transistor and the first junctionless transistor comprise an opposite dopant polarity are stacked in a vertical arrangement, where the first and second junctionless transistors are separated by an insulating layer. The invention makes use of the fact that the transistors are uniformly doped with the same polarity to provide a junctionless transistor. The junctionless concept provides that the junction is already formed, so there is no high temperature step associated with junction formation or junction regrowth. This is an important advantage in the junctionless concept in relation to 3D monolithic integration that allows for vertical stacking of the transistors to form a three dimensional CMOS inverter.

Abstract translation: 本发明提供一种三维（3D）半导体器件，其包括掺杂有相同极性的掺杂剂的第一无结晶体晶体管; 掺杂相同极性的掺杂剂的第二无结晶体晶体管; 并且第二无连接晶体管和包括相反掺杂剂极性的第一无连接晶体管以垂直布置堆叠，其中第一和第二无连接晶体管被绝缘层分开。 本发明利用以相同极性均匀掺杂的晶体管来提供无连接晶体管的事实。 无连接的概念提供了结已经形成，因此没有与结形成或连接再生长有关的高温步骤。 这在与3D单片集成相关的无连接概念中是重要的优点，其允许晶体管的垂直堆叠以形成三维CMOS反相器。

公开(公告)号：US20150303345A1

公开(公告)日：2015-10-22

申请号：US14646649

申请日：2013-11-25

Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Inventor： Farzan Gity ,  Brian Corbett ,  Alan Morrison ,  John Hayes

IPC: H01L31/109 ,  H01L27/146 ,  H01L31/0216

CPC classification number: H01L31/109 ,  H01L21/187 ,  H01L27/1465 ,  H01L31/02161 ,  H01L31/028 ,  H01L31/1804 ,  Y02E10/547 ,  Y02P70/521

Abstract: In one embodiment the invention relates to a photodetector device sensitive for wavelengths comprising a doped Ge absorbing material bonded to a substrate material locally of opposite doping polarity and an interface layer formed between the Ge absorbing material and the substrate material to form a p-n junction. In one embodiment the bonded material comprises a p-doped Ge wafer and n-doped Si or So I wafer and obtained from a low-temperature heat treatment after bonding. The invention also discloses a process for making a photodetector.

Abstract translation: 在一个实施例中，本发明涉及一种对于波长敏感的光电检测器件，其包括局部具有相反掺杂极性的基底材料结合的掺杂Ge吸收材料和形成在Ge吸收材料和衬底材料之间以形成p-n结的界面层。 在一个实施例中，粘合材料包括p掺杂的Ge晶片和n掺杂的Si或So I晶片，并且在结合之后由低温热处理获得。 本发明还公开了一种制造光电检测器的方法。

公开(公告)号：US08642350B2

公开(公告)日：2014-02-04

申请号：US13074187

申请日：2011-03-29

Applicant: Dmitri Papkovsky

Inventor： Dmitri Papkovsky

IPC: G01N31/22 ,  G01N21/80 ,  G01N21/77

CPC classification number: C09K9/02 ,  C09K2211/1029 ,  C09K2211/185 ,  G01N31/225 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/7786

Abstract: A sensor material of the type comprising a long-decay photoluminescent, protonable dye embedded in a suitable polymeric matrix, is used for generating a specific optical response to two different analytes present in a sample, thus allowing selective determination of the two analytes in the sample. Also described is a method for the simultaneous sensing of a first and second analyte in a sample. The method comprises the steps of irradiating a sensor material of the type comprising a long-decay photoluminescent protonable dye embedded in a suitable polymeric matrix with light of one or two wavelengths, determining photoluminescence intensity and lifetime signals originating from the sensor, and correlating the photoluminescence intensity signal with a concentration of the first analyte and the photoluminescence lifetime signal(s) with the concentration of the second analyte.

Abstract translation: 使用包含嵌入合适的聚合物基质中的长衰减光致发光，可质子化染料的传感器材料，以产生对存在于样品中的两种不同分析物的特定光学响应，从而允许选择性地测定样品中的两种分析物 。 还描述了用于同时检测样品中的第一和第二分析物的方法。 该方法包括以下步骤：将包含长时间衰变的光致发光可质子化染料的传感器材料照射在合适的聚合物基质中，其具有一个或两个波长的光，确定来自传感器的光致发光强度和寿命信号，并将光致发光 具有第一分析物的浓度的强度信号和具有第二分析物浓度的光致发光寿命信号。

公开(公告)号：US20130275049A1

公开(公告)日：2013-10-17

申请号：US13698660

申请日：2011-05-18

Applicant: Audrey Dunn-Galvin ,  Jonathan B. O'Hourihane

Inventor： Audrey Dunn-Galvin ,  Jonathan B. O'Hourihane

IPC: G06F19/00

CPC classification number: G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70

Abstract: A method of assessing the allergic status of a subject to a specific allergen, comprises the steps of determining a subject-specific numeric value for a plurality of variables comprising age, sex, SPT, IgE, (sIgE or tIgE minus sIgE) and allergic symptoms, applying an allergen-specific weighting to the numeric value for each variable, and correlating the weighted numeric values with allergic status for the subject. The weighted numeric values is correlated with allergenicity status using a deterministic probability function.

Abstract translation: 评估受试者对特定变应原的过敏状态的方法包括以下步骤：确定包括年龄，性别，SPT，IgE，（sIgE或tIgE减去sIgE）和变态反应症状的多种变量的受试者特异性数值 对每个变量对数值应用变应原特异性权重，并将加权数值与受试者的过敏状态相关联。 加权数值与使用确定性概率函数的变应原性状态相关。

公开(公告)号：US20130154690A1

公开(公告)日：2013-06-20

申请号：US13715529

申请日：2012-12-14

Applicant: University College Cork -National University of Ireland, Cork

Inventor： Michael Peter Kennedy

IPC: H03B21/00

CPC classification number: H03B21/00 ,  H03L7/1974

Abstract: Methods and systems are disclosed that provide a radio frequency synthesizer that generates precise frequencies over a large radio frequency range. The radio frequency synthesizer can provide a high resolution of frequency generation and still provide precise frequencies over a range of radio frequencies. The precision and resolution while maintaining a large operating range come from the ability of the frequency synthesizer to generate frequencies as a product of a plurality of moduli. For example, the frequency can be generated from a reference frequency using a first modulus and a second modulus. The plurality of modulo can be implemented using nested digital delta-sigma modulators in a fractional-N frequency synthesizer.

Abstract translation: 公开了提供在大的射频范围内产生精确频率的射频合成器的方法和系统。 无线电频率合成器可以提供高分辨率的频率产生，并且还能在无线电频率范围内提供精确的频率。 维持较大工作范围的精度和分辨率来自于频率合成器产生频率作为多个模数乘积的能力。 例如，可以使用第一模数和第二模数从参考频率产生频率。 可以使用分数N频率合成器中的嵌套数字Δ-Σ调制器来实现多个模数。

公开(公告)号：US20120289681A1

公开(公告)日：2012-11-15

申请号：US13143309

申请日：2009-06-08

Applicant: Dmitri Papkovsky ,  Ruslan Dmitriev

Inventor： Dmitri Papkovsky ,  Ruslan Dmitriev

IPC: C07K7/08 ,  C07K7/06 ,  C07K7/02 ,  C07K2/00

CPC classification number: A61K49/0015 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/6432 ,  G01N2021/6439

Abstract: A phosphorescent compound of general Formula I, or phosphorescent analogs thereof, wherein: at least one of R1 to R4 has a formula X—Y, wherein Y is a peptide sequence providing cell penetration, and X is absent or is a chemical linker; the or each of the remaining R1 to R4 groups are, independently, lipophilic, uncharged chemical groups; and Me is selected from Pt2+ or Pd2+, which probe is capable of measurement of molecular oxygen within live respiring cells by quenched-phosphorescence detection.

Abstract translation: 一种通式I的磷光化合物或其磷光类似物，其中：R 1至R 4中的至少一个具有式X-Y，其中Y为提供细胞穿透的肽序列，X不存在或为化学连接体; 剩余的R 1至R 4基团中的或每一个独立地为亲脂性，不带电荷的化学基团; 并且Me选自Pt2 +或Pd2 +，该探针能够通过淬灭磷光检测来测量活的呼吸细胞内的分子氧。

公开(公告)号：US20120177608A1

公开(公告)日：2012-07-12

申请号：US13330744

申请日：2011-12-20

Applicant: Paul Ross ,  Debebe Alemayehu ,  Colin Hill ,  James Gerard Martin

Inventor： Paul Ross ,  Debebe Alemayehu ,  Colin Hill ,  James Gerard Martin

IPC: A61K35/76 ,  A61P31/04 ,  C12N7/00

CPC classification number: C12N7/00 ,  A61K35/76 ,  C12N2795/10132 ,  C12N2795/10232

Abstract: An isolated bacteriophage MR299-2 or NH-4 deposited under NCIMB Deposit Accession Nos. 41729 and 41730, respectively, is described. The phages have lytic activity against P. aeruginosa strains, including mucoid and CF clinical isolate strains. Variant hages are also described, wherein said variants retain the phenotypic characteristics of said phage and wherein said phage and variants thereof have lytic activity against P. aeruginosa strains.

Abstract translation: 描述了分别在NCIMB沉积物登录号41729和41730下沉积的分离的噬菌体MR299-2或NH-4。 噬菌体对铜绿假单胞菌菌株具有裂解活性，包括粘液样和CF临床分离菌株。 还描述了变体hage，其中所述变体保留所述噬菌体的表型特征，并且其中所述噬菌体及其变体具有针对铜绿假单胞菌菌株的裂解活性。

公开(公告)号：US20110136898A1

公开(公告)日：2011-06-09

申请号：US13057548

申请日：2009-08-05

Applicant: Thomas Cotter ,  Francesca Doonan ,  Nuria Sanvicens Diez ,  Carolyn O' Driscoll ,  Angel Ramon Messeguer Peypoch

Inventor： Thomas Cotter ,  Francesca Doonan ,  Nuria Sanvicens Diez ,  Carolyn O' Driscoll ,  Angel Ramon Messeguer Peypoch

IPC: A61K31/353 ,  A61P27/02

CPC classification number: A61K31/353 ,  A61K9/0048 ,  A61K9/0051

Abstract: The use of a compound of general formula (I): or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment or prevention of a disease or condition characterised by apoptosis or degeneration of mammalian cells, wherein: R1 is a alkoxy, alkyl, ether or ester group; R2 is H or has the formula wherein Y is linear or branched, saturated or unsaturated, aliphatic group with from 2 to 23 carbon atoms, or a cyclic group, and which can contain substituents selected from the group consisting of hydroxyl, alkoxy, amino, carboxyl, cyano, nitro, alkylsuphonyl or halogen atoms, X is O or S; and R3 is any substituent.

Abstract translation: 通式（I）的化合物或其药学上可接受的盐在制备用于治疗或预防以哺乳动物细胞凋亡或变性为特征的疾病或病症的药物中的用途，其中：R1是烷氧基 ，烷基，醚或酯基; R 2为H或具有下式其中Y为具有2至23个碳原子的直链或支链，饱和或不饱和的脂族基团或环状基团，并且其可以含有选自羟基，烷氧基，氨基， 羧基，氰基，硝基，烷基仲酰基或卤素原子，X是O或S; 并且R 3是任何取代基。

公开(公告)号：US20110136163A1

公开(公告)日：2011-06-09

申请号：US12997073

申请日：2008-06-25

Applicant: Dmitri Papkovsky ,  Grzegorz Jasionek ,  Alexander Zhdanov

Inventor： Dmitri Papkovsky ,  Grzegorz Jasionek ,  Alexander Zhdanov

IPC: G01N33/50 ,  C12Q1/02 ,  G01N27/26

CPC classification number: G01N33/5014

Abstract: A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function; and correlating the measured data of the at least one parameter of cellular function with toxicity, wherein the step of exposing the cells to the candidate agent is carried out in the presence of a reagent capable of facilitating transport of the candidate agent into the cell. The transport reagent may be an endocytosis, pinocytosis inducing agent, a peptide, or a liposome. The at least one parameter of cellular function may be selected from the group consisting of: cell viability; proliferation rate; membrane integrity; and a metabolic parameter. Also described is a method of generating a toxicity signature for a candidate agent comprising the step of carrying out the method of the invention for a plurality of cellular function parameters, and compiling the measured data for each of the cellular function parameters to provide a toxicity signature.

Abstract translation: 评估候选试剂对细胞样品的毒性的方法包括以下步骤：提供细胞样品，将细胞暴露于候选试剂一段合适的时间，测定细胞以测量至少一个参数的数据 细胞功能; 以及将所述至少一个细胞功能参数的测量数据与毒性相关联，其中将所述细胞暴露于所述候选试剂的步骤在能够促进候选试剂转运到细胞中的试剂存在下进行。 转运试剂可以是内吞作用，促生成细胞诱导剂，肽或脂质体。 细胞功能的至少一个参数可以选自：细胞活力; 增殖率; 膜完整性; 和代谢参数。 还描述了生成候选药剂的毒性特征的方法，其包括对多个细胞功能参数进行本发明的方法的步骤，以及编码每个细胞功能参数的测量数据以提供毒性特征 。

公开(公告)号：US20110110853A1

公开(公告)日：2011-05-12

申请号：US13001880

申请日：2009-06-30

Applicant: Noel Caplice

Inventor： Noel Caplice

IPC: A61K51/10 ,  C12N5/071 ,  G01N33/53 ,  A61K35/12 ,  A61K49/00 ,  A61P9/00

CPC classification number: G01N33/6893 ,  C12N5/0692 ,  G01N33/56966 ,  G01N2800/32

Abstract: Described herein are isolated mammalian cells (progenitor cell biomarkers), referred to as primitive vascular progenitor cells (PVPC), which are present in and isolated from blood (e.g., peripheral blood) and useful as biomarkers of vascular remodeling in mammals (e.g., humans, rodents).

Abstract translation: 本文描述的是分离的哺乳动物细胞（祖细胞生物标志物），被称为原始血管祖细胞（PVPC），其存在于血液中并且从血液中分离（例如外周血），并且可用作哺乳动物（例如，人）中血管重塑的生物标志物 ，啮齿动物）。