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    BRANCHED PEPTIDES FOR ENZYMATIC ASSEMBLY AND MITOCHONDRIA DRUG DELIVERY
    94.
    发明申请
    BRANCHED PEPTIDES FOR ENZYMATIC ASSEMBLY AND MITOCHONDRIA DRUG DELIVERY 有权

    公开(公告)号：US20220112240A1

    公开(公告)日：2022-04-14

    申请号：US17537418

    申请日：2021-11-29

    申请人： BRANDEIS UNIVERSITY

    发明人： Hongjian HE ,  Bing XU

    IPC分类号： C07K7/06 ,  C07K7/08 ,  A61K9/107 ,  C07K19/00 ,  A61P9/00 ,  A61P35/00

    摘要： The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.

    High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
    96.
    发明授权
    High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides 有权

    公开(公告)号：US11268099B2

    公开(公告)日：2022-03-08

    申请号：US16538291

    申请日：2019-08-12

    申请人： Brandeis University

    发明人： Isaac J. Krauss

    IPC分类号： C12N15/117 ,  C12Q1/6886 ,  G01N33/574 ,  C07H21/04 ,  A61K39/21 ,  C12N15/10 ,  C12P19/34 ,  G01N33/53 ,  G01N33/68 ,  A61K39/00

    摘要： The invention relates to an oligonucleotide including one or more modified nucleoside bases having the structure -B-L-A wherein for each of the modified nucleosides A is independently a monosaccharide or oligosaccharide, Lisa linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide; and wherein the oligonucleotide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nM. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. Various method of using the oligonucleotides, immunogenic conjugates, and pharmaceutical compositions are disclosed, including inducing an immune response, inhibiting viral or bacterial infection, treating a cancerous condition, and detecting a neutralizing antibody. A method is also disclosed for selecting the oligonucleotides using an alternative Selection of Modified Aptamers (SELMA).

    Branched peptides for enzymatic assembly and mitochondria drug delivery
    98.
    发明授权
    Branched peptides for enzymatic assembly and mitochondria drug delivery 有权

    公开(公告)号：US11191724B2

    公开(公告)日：2021-12-07

    申请号：US16648295

    申请日：2018-09-18

    申请人： BRANDEIS UNIVERSITY

    发明人： Hongjian He ,  Bing Xu

    IPC分类号： C07K7/06 ,  A61K9/107 ,  A61K47/69 ,  A61P35/00 ,  A61K31/704 ,  A61K47/42

    摘要： The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.

    Devices for simultaneous generation and storage of isolated droplets, and methods of making and using the same
    99.
    发明授权
    Devices for simultaneous generation and storage of isolated droplets, and methods of making and using the same 有权

    公开(公告)号：US11148140B2

    公开(公告)日：2021-10-19

    申请号：US16477749

    申请日：2018-01-16

    申请人： BRANDEIS UNIVERSITY

    发明人： Seth Fraden

    IPC分类号： B01L3/00 ,  B01L3/02

    摘要： A microfluidic device comprising at least one isolation unit and at least one capillary valve. The at least one isolation unit has at least one chamber. The at least one chamber configured to receive at least two different aqueous solutions. The at least one capillary valve is configured to allow for the at least two different aqueous solutions to be introduced into the at least one chamber without mixing prior to entering the at least one chamber based at least in part on pressure levels of the at least two different aqueous solutions.