公开(公告)号：US12117341B1

公开(公告)日：2024-10-15

申请号：US18523463

申请日：2023-11-29

Applicant: ANSWERAY INC.

Inventor： Seong Ho Cho

IPC: G01J3/04 ,  G01J3/02 ,  G01J3/18 ,  G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/0208 ,  G01J3/04 ,  G01J3/2823

Abstract: Disclosed is a spectrometer including a slit unit and a collimating member sequentially arranged along a path of pre-diffraction radiation light, a focusing member and a detection unit sequentially arranged along a path of post-diffraction radiation light, and the diffraction grating located between the collimating member and the focusing member, wherein the slit unit, the collimating member, the diffraction grating, and the focusing member are seated in one plane and are spaced apart from each other by a predetermined distance, and the detection unit is spaced apart from one plane and is located under or above the diffraction grating.

公开(公告)号：US20240264460A1

公开(公告)日：2024-08-08

申请号：US18289878

申请日：2022-05-09

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  TRUSTEES OF BOSTON UNIVERSITY

Inventor： Kelvin Wagner ,  Nathan Dostart ,  Michael P. Brand ,  Milos Popovic ,  Bohan Zhang

IPC: G02B27/42 ,  G01J3/02 ,  G01J3/18 ,  G01J3/28 ,  G02B5/18

CPC classification number: G02B27/4272 ,  G01J3/0259 ,  G01J3/1804 ,  G01J3/2803 ,  G02B5/188

Abstract: A serpentine integrated grating spectrometer includes a serpentine delay line and a plurality of grating couplers. The serpentine delay line includes a plurality of parallel waveguide segments that are coplanar in a delay-line plane. The serpentine delay line serially connects each of the plurality of grating couplers. Each of the plurality of grating couplers (i) is located at a respective one of the plurality of parallel waveguide segments, and (ii) direct light propagating in the serpentine delay line out of the delay-line plane. The plurality of waveguide segments is M in number and impart a total group delay time ry on light propagating therethrough. Each of the plurality of grating couplers impart a grating coupler delay tx on light propagating therethrough that exceeds (ty/M), the time delay for a single segment of the M parallel segments.

公开(公告)号：US20180274977A1

公开(公告)日：2018-09-27

申请号：US15926362

申请日：2018-03-20

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Chanwook BAIK ,  Jaekwan KIM ,  Byonggwon SONG ,  Kiyeon YANG ,  Jaesoong LEE ,  Jeongyub LEE ,  Kyungsang CHO

IPC: G01J3/02 ,  F21V7/22 ,  G02B5/20

CPC classification number: G01J3/021 ,  F21V7/22 ,  G01J3/0224 ,  G01J3/1804 ,  G01J3/26 ,  G01J2003/1861 ,  G02B5/1809 ,  G02B5/1866 ,  G02B5/20 ,  G02B5/203 ,  G02B27/4272

Abstract: An optical filter may include a first reflector and a second reflector. The first reflector may include a plurality of first gratings having a first sub-wavelength dimension and being arranged to recur at a first interval in a first direction. The second reflector may be spaced apart from the first reflector and include a plurality of second gratings having a second sub-wavelength dimension and arranged to recur at a second interval in a direction parallel to the first direction. The first reflector and the second reflector may include different materials or different geometric structures from each other. Accordingly, it is easy to adjust the transmission wavelength characteristics of the optical filter.

公开(公告)号：US20180120555A1

公开(公告)日：2018-05-03

申请号：US15340253

申请日：2016-11-01

Applicant: Canon USA Inc. ,  The General Hospital Corporation

Inventor： Mitsuhiro Ikuta ,  Guillermo J. Tearney ,  Dongkyun Kang ,  Dukho Do

IPC: G02B23/24 ,  G02B6/34 ,  G02B23/26 ,  G02B26/10 ,  G02B27/42 ,  G02B6/293 ,  G01J3/18 ,  G01J3/02 ,  G01J3/28 ,  A61B5/00 ,  A61B1/04 ,  A61B1/06

CPC classification number: G02B23/2469 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00179 ,  A61B1/0638 ,  A61B5/0075 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01J3/10 ,  G01J3/1804 ,  G01J3/2823 ,  G01J3/36 ,  G02B6/29313 ,  G02B6/2938 ,  G02B6/30 ,  G02B6/34 ,  G02B6/3624 ,  G02B23/26 ,  G02B26/106 ,  G02B27/4294

Abstract: An apparatus comprising at least: a first waveguide; a second waveguide; and a diffractive element. The first waveguide guides a first band of onto the diffractive element such that the first band is diffracted at an mth non-zero order over a first range of angles. The second waveguide guides a second band onto the diffractive element such that the second band is diffracted at the mth non-zero over the first range of angles. The second waveguide guides a third band onto the diffractive element such that the third band is diffracted at the nth non-zero order over the first range of angles. Wavelengths of the first band, the second band, and the third band do not overlap with each other. The mth order and the nth order are different from each other.

公开(公告)号：US09404861B2

公开(公告)日：2016-08-02

申请号：US14617635

申请日：2015-02-09

Applicant: Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville

Inventor： Junpeng Guo

IPC: G01N21/552 ,  G01J3/18 ,  G02B5/18 ,  G01N21/65 ,  G02B5/00

CPC classification number: G01N21/554 ,  G01J3/1804 ,  G01N21/658 ,  G01N2201/02 ,  G01N2201/06113 ,  G02B5/008 ,  G02B5/18 ,  G02B5/1809

Abstract: The present disclosure pertains to metal or dielectric nanostructures of the subwavelength scale within the grating lines of optical diffraction gratings. The nanostructures have surface plasmon resonances or non-plasmon optical resonances. A linear photodetector array is used to capture the resonance spectra from one of the diffraction orders. The combined nanostructure super-grating and photodetector array eliminates the use of external optical spectrometers for measuring surface plasmon or optical resonance frequency shift caused by the presence of chemical and biological agents. The nanostructure super-gratings can be used for building integrated surface enhanced Raman scattering (SERS) spectrometers. The nanostructures within the diffraction grating lines enhance Raman scattering signal light while the diffraction grating pattern of the nanostructures diffracts Raman scattering light to different directions of propagation according to their wavelengths. Therefore, the nanostructure super-gratings allows for the use of a photodetector array to capture the surface enhanced Raman scattering spectra.

公开(公告)号：US20160187200A1

公开(公告)日：2016-06-30

申请号：US14909666

申请日：2014-08-04

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： Jacques LUCE

IPC: G01J3/30 ,  G01J3/18

CPC classification number: G01J3/30 ,  G01J3/0205 ,  G01J3/0256 ,  G01J3/1804

Abstract: A spectrometer including: a spectral dispersion mechanism of an initial light beam; and a photodetector. The spectral dispersion mechanism includes at least three reflective diffraction gratings parallel to consecutive sides of a convex polygon, arranged such that a portion of the initial light beam is diffracted once by each diffraction grating in turn and is diffracted at least a second time by at least one of the diffraction gratings.

Abstract translation: 一种光谱仪，包括：初始光束的光谱色散机构; 和光电检测器。 光谱色散机构包括平行于凸多边形的连续侧面的至少三个反射衍射光栅，其布置成使得初始光束的一部分依次由每个衍射光栅衍射一次，并且至少第二次衍射至少 其中一个衍射光栅。

公开(公告)号：US09322780B2

公开(公告)日：2016-04-26

申请号：US13774539

申请日：2013-02-22

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Thomas Kalkbrenner ,  Ralf Wolleschensky

IPC: G01N21/64 ,  G02B21/16 ,  G01J3/18 ,  G01J3/44

CPC classification number: G01N21/64 ,  G01J3/1804 ,  G01J3/4406 ,  G01N21/6456 ,  G02B21/16

Abstract: A method for wavelength-resolving and high spatial resolution fluorescence microscopy in which fluorescence labels in a sample are repeatedly excited to emit fluorescence radiation and frames including images of isolated labels are produced with a microscope. The positions of the images of the isolated fluorescing labels are localized with a localization precision exceeding the optical resolution of the imaging beam path of the microscope. The imaging beam path of the microscope has a diffractive element which, during the imaging, diffracts the image of the sample comprising the isolated fluorescing labels into a first diffraction order so that each frame contains the first diffraction order images of the isolated fluorescing labels. A parameter of the first diffraction order images of the isolated fluorescing labels is evaluated and an indication of the wavelength of the isolated fluorescing labels is derived from this evaluated parameter.

Abstract translation: 一种用于波长分辨和高空间分辨率荧光显微镜的方法，其中样品中的荧光标记被重复激发以发射荧光辐射，并且使用显微镜产生包括分离标记图像的框架。 分离的荧光标记的图像的位置以超过显微镜的成像光束路径的光学分辨率的定位精度进行定位。 显微镜的成像光束路径具有衍射元件，其在成像期间将包含分离的荧光标记的样品的图像衍射成第一衍射级，使得每个帧包含分离的荧光标记的第一衍射级图像。 评估分离的荧光标记的第一衍射级图像的参数，并从该评估参数导出分离的荧光标记的波长的指示。

公开(公告)号：US09274348B2

公开(公告)日：2016-03-01

申请号：US14302180

申请日：2014-06-11

Applicant: Sumitomo Electric Industries, Ltd.

Inventor： Manabu Shiozaki ,  Hidehisa Tazawa

IPC: G02B5/18 ,  G02B27/42 ,  G02B27/10 ,  G01J3/14 ,  G01J3/18 ,  G01J3/02

CPC classification number: G02B27/4244 ,  G01J3/0286 ,  G01J3/14 ,  G01J3/1804 ,  G02B27/1006 ,  G02B27/4283

Abstract: A dispersive device has a beam expanding optical system which includes first and second prisms each having a pair of faces inclined relative to each other, and expands light containing a plurality of wavelength components by passing the light through each of the faces of the first and second prisms; and a dispersive element which emits the light expanded by the beam expanding optical system, at different diffraction angles by the respective wavelength components. A direction of variation of an output angle of the light emitted from the beam expanding optical system due to temperature change is configured to be a direction to suppress variation of the diffraction angles of the respective wavelength components emitted from the dispersive element due to the temperature change.

Abstract translation: 分散装置具有扩束光学系统，该光束扩展光学系统包括第一和第二棱镜，每个棱镜具有相对于彼此倾斜的一对面，并且通过使光穿过第一和第二透镜的每个面而使包含多个波长分量的光展开 棱镜 以及分散元件，其通过各个波长分量以不同的衍射角发射由扩束光学系统扩展的光。 由于温度变化而从扩束光学系统发射的光的输出角度的变化方向被配置为抑制由于温度变化而从色散元件发射的各个波长分量的衍射角的变化的方向 。

公开(公告)号：US20150294076A1

公开(公告)日：2015-10-15

申请号：US14440987

申请日：2013-11-06

Applicant: Patrick TREADO ,  Shona STEWART ,  Heather KIRSCHNER ,  Ryan PRIORE ,  Alan WILSON ,  CHEMIMAGE CORPORATION

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G06F19/00 ,  G06F19/24 ,  G01N21/65 ,  G01N33/49

CPC classification number: G16H50/20 ,  G01J3/1804 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N33/49 ,  G01N33/57419 ,  G16B40/00

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

Abstract translation: 用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。 使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。 该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。 系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。 检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。 该系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置分析样本。

公开(公告)号：US08976359B2

公开(公告)日：2015-03-10

申请号：US13716122

申请日：2012-12-15

Applicant: Junpeng Guo

Inventor： Junpeng Guo

IPC: G02B5/18 ,  G01N21/55 ,  G01N21/552 ,  G01N21/65

CPC classification number: G01N21/554 ,  G01J3/1804 ,  G01N21/658 ,  G01N2201/02 ,  G01N2201/06113 ,  G02B5/008 ,  G02B5/18 ,  G02B5/1809

Abstract: The present disclosure pertains to metal or dielectric nanostructures of the subwavelength scale within the grating lines of optical diffraction gratings. The nanostructures have surface plasmon resonances or non-plasmon optical resonances. A linear photodetector array is used to capture the resonance spectra from one of the diffraction orders. The combined nanostructure super-grating and photodetector array eliminates the use of external optical spectrometers for measuring surface plasmon or optical resonance frequency shift caused by the presence of chemical and biological agents. The nanostructure super-gratings can be used for building integrated surface enhanced Raman scattering (SERS) spectrometers. The nanostructures within the diffraction grating lines enhance Raman scattering signal light while the diffraction grating pattern of the nanostructures diffracts Raman scattering light to different directions of propagation according to their wavelengths. Therefore, the nanostructure super-gratings allows for the use of a photodetector array to capture the surface enhanced Raman scattering spectra.

Abstract translation: 本公开涉及在光学衍射光栅的光栅线内的亚波长标尺的金属或电介质纳米结构。 纳米结构具有表面等离子体共振或非等离子体光学共振。 线性光电检测器阵列用于从一个衍射级捕获共振光谱。 组合的纳米结构超光栅和光电检测器阵列消除了使用外部光谱仪来测量由化学和生物试剂的存在引起的表面等离子体激元或光学共振频移。 纳米结构超光栅可用于构建集成表面增强拉曼散射（SERS）光谱仪。 衍射光栅线内的纳米结构增强了拉曼散射信号光，而纳米结构的衍射光栅图案根据其波长将拉曼散射光衍射到不同的传播方向。 因此，纳米结构超光栅允许使用光电检测器阵列来捕获表面增强的拉曼散射光谱。