公开(公告)号：US20200300762A1

公开(公告)日：2020-09-24

申请号：US16089394

申请日：2017-03-08

Applicant: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Shigetoshi OKAZAKI

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/36 ,  G02B21/02

Abstract: An image acquisition apparatus includes a spatial light modulator, an optical scanner, a detection unit, a control unit. The spatial light modulator performs focused irradiation on irradiation regions on a surface or inside of an observation object with modulated excitation light. The detection unit has imaging regions in an imaging relation with the irradiation regions on a light receiving surface, each of the imaging regions corresponds to one or two or more pixels, and a pixel that corresponds to none of the imaging regions exists adjacent to each imaging region. The control unit corrects a detection signal of a pixel corresponding to each imaging region on the basis of a detection signal of the pixel that exists adjacent to the imaging region and corresponds to none of the imaging regions, and generates an image of the observation object on the basis of the corrected detection signal.

公开(公告)号：US20190147816A1

公开(公告)日：2019-05-16

申请号：US16229980

申请日：2018-12-21

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Takashi INOUE ,  Norihiro FUKUCHI ,  Yuji KOBAYASHI ,  Tsutomu HARA

IPC: G09G3/36 ,  G01M11/02 ,  G02F1/133 ,  G09G5/10

Abstract: In an apparatus for modulating light, a spatial light modulator includes a plurality of pixels and configured to modulate input light in response to a drive voltage for each of the pixels. An input value setting unit is configured to set an input value for the each of pixels. The input value is a digital value, an entire gray level of the digital value is “N”, and “N” is a natural number. A converting unit is configured to convert the input value to a control value. A control value is a digital value, an entire gray level of the control value is “M”, and “M” is a natural number greater than “N”. A driving unit is configured to convert the control value to a voltage value and drive the each of the pixels in response to the drive voltage corresponding to the voltage value.

公开(公告)号：US20190033284A1

公开(公告)日：2019-01-31

申请号：US16046530

申请日：2018-07-26

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Koyo WATANABE ,  Hirotoshi TERADA

IPC: G01N33/483 ,  G01N21/41 ,  G03H1/00 ,  G01N21/64 ,  G02B27/00 ,  G03H1/08 ,  G02B5/32 ,  G01B11/24 ,  G03H1/22 ,  G02B21/00 ,  G01N21/63

CPC classification number: G01N33/4833 ,  G01B11/24 ,  G01N21/41 ,  G01N21/636 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B5/32 ,  G02B21/00 ,  G02B21/16 ,  G02B27/0068 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0072

Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

公开(公告)号：US20140232766A1

公开(公告)日：2014-08-21

申请号：US14264692

申请日：2014-04-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Takashi INOUE ,  Norihiro FUKUCHI ,  Yuji KOBAYASHI ,  Tsutomu HARA

IPC: G09G5/10

CPC classification number: G09G3/3648 ,  G01M11/0257 ,  G01M11/0271 ,  G02F1/13306 ,  G02F1/136277 ,  G02F2001/136254 ,  G02F2001/215 ,  G02F2203/12 ,  G02F2203/50 ,  G02F2203/69 ,  G09G3/3611 ,  G09G5/10 ,  G09G2300/0491 ,  G09G2300/08 ,  G09G2320/02 ,  G09G2320/0693

Abstract: In an apparatus for modulating light, an spatial light modulator includes a plurality of pixels and configured to modulate input light in response to a drive voltage for each of the pixels. An input value setting unit is configured to set an input value for the each of pixels. The input value is a digital value, an entire gray level of the digital value is “N”, and “N” is a natural number. A converting unit is configured to convert the input value to a control value. A control value is a digital value, an entire gray level of the control value is “M”, and “M” is a natural number greater than “N”. A driving unit is configured to convert the control value to a voltage value and drive the each of the pixels in response to the drive voltage corresponding to the voltage value.

Abstract translation: 在用于调制光的装置中，空间光调制器包括多个像素并且被配置为响应于每个像素的驱动电压来调制输入光。 输入值设置单元被配置为设置每个像素的输入值。 输入值为数字值，数字值的整个灰度级为“N”，“N”为自然数。 A转换单元被配置为将输入值转换为控制值。 控制值为数字值，控制值的全部灰度级为“M”，“M”为大于“N”的自然数。 驱动单元被配置为将控制值转换为电压值，并且响应于对应于电压值的驱动电压驱动每个像素。

公开(公告)号：US20130242373A1

公开(公告)日：2013-09-19

申请号：US13871396

申请日：2013-04-26

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Taro ANDO ,  Takashi INOUE ,  Yoshiyuki OHTAKE

IPC: G02B26/06

CPC classification number: G02B26/06 ,  G02B21/086 ,  G02B26/0808 ,  G02B27/4205 ,  G02F2203/12

Abstract: A light control device 1 includes a light source 10, a prism 20, a spatial light modulator 30, a drive unit 31, a control unit 32, a lens 41, an aperture 42, and a lens 43. The spatial light modulator 30 is a phase modulating spatial light modulator, includes a plurality of two-dimensionally arrayed pixels, is capable of phase modulation in each of these pixels in a range of 4π or more, and presents a phase pattern to modulate the phase of light in each of the pixels. This phase pattern is produced by superimposing a blazed grating pattern for light diffraction and a phase pattern having a predetermined phase modulation distribution, and with a phase modulation range of 2π or more.

Abstract translation: 光控制装置1包括光源10，棱镜20，空间光调制器30，驱动单元31，控制单元32，透镜41，孔42和透镜43.空间光调制器30是 包括多个二维排列的像素的相位调制空间光调制器能够在4pi或更大的范围内在这些像素的每一个中进行相位调制，并且呈现相位图案以调制每个像素中的每一个中的相位 像素。 该相位图案通过叠加用于光衍射的闪耀光栅图案和具有预定相位调制分布的相位图案，并且相位调制范围为2pi或更大来产生。

公开(公告)号：US20180143137A1

公开(公告)日：2018-05-24

申请号：US15858818

申请日：2017-12-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Koyo WATANABE ,  Hirotoshi TERADA

IPC: G01N21/64 ,  G02B21/08 ,  G01B11/24 ,  G03H1/00 ,  G02B21/26 ,  G01B9/021

CPC classification number: G01N21/6458 ,  G01B9/021 ,  G01B11/24 ,  G01N21/64 ,  G01N21/6486 ,  G01N2201/06113 ,  G02B5/32 ,  G02B21/00 ,  G02B21/08 ,  G02B21/26 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0068 ,  G03H1/0005 ,  G03H2001/005

Abstract: A microscope apparatus (1A) includes a biological sample table (11) that supports the biological sample (B), an objective lens (12) disposed to face the biological sample table (11), a laser light source (13) that outputs light with which the biological sample (B) is irradiated via the objective lens (12), a shape measurement unit (20) that acquires a surface shape of the biological sample (B), a control unit (40) that generates aberration correction hologram data for correcting an aberration caused by the surface shape of the biological sample (B) on the basis of information acquired in the shape measurement unit (20), a first spatial light modulator (33) to which a hologram based on the aberration correction hologram data is presented and that modulates the light output from the laser light source (31), and a photodetector (37) that detects an intensity of light to be detected (L2) generated in the biological sample (B). Thus, a microscope apparatus and an image acquisition method capable of suppressing a decrease in condensing intensity of irradiation light inside a biological sample and spreading of a condensing shape are realized.

公开(公告)号：US20170030776A1

公开(公告)日：2017-02-02

申请号：US15303900

申请日：2015-04-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takashi INOUE ,  Koyo WATANABE ,  Koji TAKAHASHI ,  Naoya MATSUMOTO

IPC: G01J11/00 ,  G02B5/32

CPC classification number: G01J11/00 ,  G01J9/00 ,  G02B5/32 ,  G02F2203/56

Abstract: A waveform measurement device includes an input spectrum acquisition unit for acquiring an input intensity spectrum being an intensity spectrum of pulsed light, an optical element inputting the pulsed light and outputting light having an intensity spectrum corresponding to a phase spectrum of the pulsed light, an output spectrum acquisition unit for acquiring an output intensity spectrum being an intensity spectrum of the light output from the optical element, and a phase spectrum determination unit for determining the phase spectrum of the pulsed light by comparing an output intensity spectrum calculated when the pulsed light having an input intensity spectrum and a virtual phase spectrum is assumed to be input to the optical element with the output intensity spectrum acquired in the output spectrum acquisition unit. The phase spectrum determination unit sets the virtual phase spectrum by deforming the control phase spectrum.

Abstract translation: 波形测量装置包括：输入频谱获取单元，用于获取作为脉冲光的强度谱的输入强度谱;输入脉冲光的光学元件，并输出具有与脉冲光的相位谱对应的强度光谱的光;输出 光谱获取单元，用于获取作为从光学元件输出的光的强度谱的输出强度谱;以及相位谱确定单元，用于通过比较当脉冲光具有 假设输入强度谱和虚拟相位谱被输入到具有在输出频谱获取单元中获取的输出强度谱的光学元件。 相位谱确定单元通过使控制相位频谱变形来设定虚拟相位频谱。

公开(公告)号：US20160202477A1

公开(公告)日：2016-07-14

申请号：US15073924

申请日：2016-03-18

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Haruyasu ITO ,  Naoya MATSUMOTO ,  Takashi INOUE

IPC: G02B27/00 ,  G02B5/18 ,  G02B21/02 ,  G02B21/00 ,  G02B21/36

CPC classification number: G02B27/0025 ,  B23K26/00 ,  B23K26/03 ,  B23K26/032 ,  B23K26/06 ,  B23K26/064 ,  B23K26/36 ,  B23K26/364 ,  B23K26/38 ,  B23K26/40 ,  B23K26/53 ,  B23K26/57 ,  B23K2101/40 ,  B23K2103/50 ,  G02B5/1876 ,  G02B5/32 ,  G02B21/0032 ,  G02B21/02 ,  G02B21/06 ,  G02B21/361 ,  G02B27/0068 ,  G02F1/01 ,  G02F2203/18

Abstract: In an aberration-correcting method according to an embodiment of the present invention, in an aberration-correcting method for a laser irradiation device 1 which focuses a laser beam on the inside of a transparent medium 60, aberration of a laser beam is corrected so that a focal point of the laser beam is positioned within a range of aberration occurring inside the medium. This aberration range is not less than n×d and not more than n×d+Δs from an incidence plane of the medium 60, provided that the refractive index of the medium 60 is defined as n, a depth from an incidence plane of the medium 60 to the focus of the lens 50 is defined as d, and aberration caused by the medium 60 is defined as Δs.

Abstract translation: 在根据本发明实施例的像差校正方法中，在将激光束聚焦在透明介质60的内部的激光照射装置1的像差校正方法中，校正激光束的像差，使得 激光束的焦点位于介质内发生的像差范围内。 该像差范围不小于介质60的入射面的n×d且不大于n×d +＆Dgr·s，条件是介质60的折射率定义为n，入射面的深度 将介质60到透镜50的焦点定义为d，并且由介质60引起的像差被定义为＆Dgr; s。

公开(公告)号：US20130341308A1

公开(公告)日：2013-12-26

申请号：US13963299

申请日：2013-08-09

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Haruyasu ITO ,  Naoya MATSUMOTO ,  Takashi INOUE

IPC: B23K26/00

CPC classification number: G02B27/0025 ,  B23K26/00 ,  B23K26/03 ,  B23K26/032 ,  B23K26/06 ,  B23K26/064 ,  B23K26/36 ,  B23K26/364 ,  B23K26/38 ,  B23K26/40 ,  B23K26/53 ,  B23K26/57 ,  B23K2101/40 ,  B23K2103/50 ,  G02B5/1876 ,  G02B5/32 ,  G02B21/0032 ,  G02B21/02 ,  G02B21/06 ,  G02B21/361 ,  G02B27/0068 ,  G02F1/01 ,  G02F2203/18

Abstract: In an aberration-correcting method according to an embodiment of the present invention, in an aberration-correcting method for a laser irradiation device 1 which focuses a laser beam on the inside of a transparent medium 60, aberration of a laser beam is corrected so that a focal point of the laser beam is positioned within a range of aberration occurring inside the medium. This aberration range is not less than n×d and not more than n×d+Δs from an incidence plane of the medium 60, provided that the refractive index of the medium 60 is defined as n, a depth from an incidence plane of the medium 60 to the focus of the lens 50 is defined as d, and aberration caused by the medium 60 is defined as Δs.

Abstract translation: 在根据本发明实施例的像差校正方法中，在将激光束聚焦在透明介质60的内部的激光照射装置1的像差校正方法中，校正激光束的像差，使得 激光束的焦点位于介质内发生的像差范围内。 该像差范围不小于介质60的入射面的n×d且不大于n×d + Deltas，条件是介质60的折射率定义为n，从 到透镜50的焦点的介质60被定义为d，并且由介质60引起的像差被定义为Deltas。

公开(公告)号：US20220019094A1

公开(公告)日：2022-01-20

申请号：US17370468

申请日：2021-07-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koyo WATANABE ,  Naoya MATSUMOTO ,  Hisanari TAKAHASHI ,  Kyohei SHIGEMATSU ,  Takashi INOUE

IPC: G02F1/01

Abstract: Provided is a light shaping device including: an intensity modulation unit that modulates a spectrum intensity of an optical pulse that is input light, and outputs the optical pulse of which a temporal width is narrowed as output light. The intensity modulation unit modulates the spectrum intensity of the optical pulse with a mask expressed by a starting end wavelength from a central wavelength of the input light and a wavelength width.