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公开(公告)号：US09920292B2
公开(公告)日：2018-03-20
申请号：US14841072
申请日：2015-08-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Reginald Donovan Smith , Kenneth Roger Conway , Anshika Bajaj
CPC classification number: C12M41/22 , C12M21/08 , C12M23/14 , C12M23/38 , C12M23/48 , C12M27/16 , C12M29/24 , C12M41/48 , C12Q3/00
Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
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公开(公告)号：US10465157B2
公开(公告)日：2019-11-05
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
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公开(公告)号：US09677975B2
公开(公告)日：2017-06-13
申请号：US14529203
申请日：2014-10-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith
CPC classification number: G01N1/18 , C12M23/00 , C12M23/40 , C12M33/00 , C12M33/06 , C12M37/02 , C12M41/00
Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
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公开(公告)号：US20160122798A1
公开(公告)日：2016-05-05
申请号：US14529203
申请日：2014-10-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith
CPC classification number: G01N1/18 , C12M23/00 , C12M23/40 , C12M33/00 , C12M33/06 , C12M37/02 , C12M41/00
Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
Abstract translation: 提供了一种采样组件，其被配置为耦合到采样源并且在一个或多个时间上促进无菌采样。 此外，采样组件包括具有第一和第二端口的第一导管，其中第一端口被配置为耦合到采样源。 采样组件还包括具有对应的子端口的多个子管道，其中多个子导管中的每一个在相应的连接器接合处可操作地联接到第一导管。 此外，每个子端口与第一导管流体连通。 采样组件还包括多个采样套件和一个或多个抽吸装置。 此外，每个采样套件可操作地耦合到相应子导管的相应子端口。 此外，一个或多个泵送装置可操作地和无菌地联接到第一管道的第二端口。
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Patent Agency Ranking
公开(公告)号：US20150299657A1
公开(公告)日：2015-10-22
申请号：US14254152
申请日：2014-04-16
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Patrick Joseph McCloskey , James Edward Pickett , Gregory Daryll Goddard , Reginald Donovan Smith , Anshika Bajaj
IPC: C12N5/078
CPC classification number: C12N5/0087 , C12N2500/50 , G01N33/491
Abstract: Provided herein are gamma stable dextran solutions and kits that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation and maintain sufficient molecular weight to act as a red blood cell aggregant. Further provided are methods of use.
Abstract translation: 本文提供了γ稳定的葡聚糖溶液和试剂盒，其通过使葡聚糖溶液通过暴露于γ辐射而被消毒并且保持足够的分子量以充当红细胞聚集体来提高血液分离的效率。 进一步提供使用的方法。
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公开(公告)号：US20170058252A1
公开(公告)日：2017-03-02
申请号：US14841072
申请日：2015-08-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Reginald Donovan Smith , Kenneth Roger Conway , Anshika Bajaj
CPC classification number: C12M41/22 , C12M21/08 , C12M23/14 , C12M23/38 , C12M23/48 , C12M27/16 , C12M29/24 , C12M41/48 , C12Q3/00
Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
Abstract translation: 提供了用于启动细胞培养的系统和方法。 该系统和方法包括一个包含位于平台表面区域上的热质量的第一外壳。 所述系统和方法包括放置在第一外壳上的包含培养液和气体混合物的第二外壳，使得第一外壳位于第二外壳和平台之间。 所述系统和方法还包括固定在第二外壳上的盖，并且在平台的表面区域上产生第一热能并且从盖产生第二热能。
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公开(公告)号：US20160053296A1
公开(公告)日：2016-02-25
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
Abstract translation: 提供了一种被配置为耦合到采样源的采样组件。 采样组件被配置为便于在一个或多个实例的时间进行无菌取样。 采样组件包括具有第一端口和第二端口的第一导管，其中第一端口被配置为耦合到采样源，并且其中第二端口被配置为气密密封。 采样组件还包括具有对应子端口的多个子导管，其中多个子导管中的每一个在相应的连接点处可操作地耦合到第一导管，并且其中每个子端口处于流体连通 与第一个导管。 此外，采样组件包括多个采样套件，其中多个采样套件的每个采样套件可操作地连接到相应副导管的相应子端口。
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公开(公告)号：US09040019B2
公开(公告)日：2015-05-26
申请号：US13689819
申请日：2012-11-30
Applicant: General Electric Company
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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公开(公告)号：US20140154178A1
公开(公告)日：2014-06-05
申请号：US13689819
申请日：2012-11-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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