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公开(公告)号：US20170258941A1
公开(公告)日：2017-09-14
申请号：US15069198
申请日：2016-03-14
Applicant: GENERAL ELECTRIC COMPANY
Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
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公开(公告)号：US09040019B2
公开(公告)日：2015-05-26
申请号：US13689819
申请日：2012-11-30
Applicant: General Electric Company
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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公开(公告)号：US20140154178A1
公开(公告)日：2014-06-05
申请号：US13689819
申请日：2012-11-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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公开(公告)号：US11730830B2
公开(公告)日：2023-08-22
申请号：US16994127
申请日：2020-08-14
Applicant: General Electric Company
CPC classification number: A61K49/0021 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61K9/0014 , A61K47/10 , A61K47/22 , A61K47/32 , A61K49/0071
Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
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Patent Agency Ranking
公开(公告)号：US20210015946A1
公开(公告)日：2021-01-21
申请号：US16994127
申请日：2020-08-14
Applicant: General Electric Company
Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
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公开(公告)号：US10744212B2
公开(公告)日：2020-08-18
申请号：US15069198
申请日：2016-03-14
Applicant: GENERAL ELECTRIC COMPANY
Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
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公开(公告)号：US20230364269A1
公开(公告)日：2023-11-16
申请号：US18350268
申请日：2023-07-11
Applicant: General Electric Company
CPC classification number: A61K49/0021 , A61K9/0014 , A61K47/22 , A61K47/32 , A61K49/0071 , A61B5/0071 , A61B5/0084 , A61K47/10 , A61B5/0068
Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
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公开(公告)号：US08977331B2
公开(公告)日：2015-03-10
申请号：US13713745
申请日：2012-12-13
Applicant: General Electric Company
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B5/4893 , A61B5/6847 , A61B17/00 , A61B90/361 , A61B90/37 , A61B2090/373 , A61B2505/05 , A61B2576/02
Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.
Abstract translation: 介绍了成像系统和方法。 该方法包括产生激发光，其被配置为在选择性地结合还包括背景物种的对象的感兴趣区域（ROI）中的靶物种的成像剂中诱导荧光。 选择第一和第二光谱区域，使得对应于目标的荧光和第一光谱区域中的背景物质之间的确定的差异与第二光谱区域中的相应差异不同。 从对应于第一和第二光谱区域的荧光产生第一和第二荧光图像。 此外，确定第一和第二荧光图像中背景物质的荧光比。 然后将第一荧光图像与所确定的比率相乘或分割，以产生从第二荧光图像中减去的中间图像，以重构背景相减的图像。
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公开(公告)号：US20140171764A1
公开(公告)日：2014-06-19
申请号：US13713745
申请日：2012-12-13
Applicant: GENERAL ELECTRIC COMPANY
IPC: A61B5/00
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B5/4893 , A61B5/6847 , A61B17/00 , A61B90/361 , A61B90/37 , A61B2090/373 , A61B2505/05 , A61B2576/02
Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.
Abstract translation: 介绍了成像系统和方法。 该方法包括产生激发光，其被配置为在选择性地结合还包括背景物种的对象的感兴趣区域（ROI）中的靶物种的成像剂中诱导荧光。 选择第一和第二光谱区域，使得对应于目标的荧光和第一光谱区域中的背景物质之间的确定的差异与第二光谱区域中的相应差异不同。 从对应于第一和第二光谱区域的荧光产生第一和第二荧光图像。 此外，确定第一和第二荧光图像中背景物质的荧光比。 然后将第一荧光图像与所确定的比率相乘或分割，以产生从第二荧光图像中减去的中间图像，以重构背景相减的图像。
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