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公开(公告)号：US09677975B2
公开(公告)日：2017-06-13
申请号：US14529203
申请日：2014-10-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith
CPC classification number: G01N1/18 , C12M23/00 , C12M23/40 , C12M33/00 , C12M33/06 , C12M37/02 , C12M41/00
Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
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公开(公告)号：US20160122798A1
公开(公告)日：2016-05-05
申请号：US14529203
申请日：2014-10-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith
CPC classification number: G01N1/18 , C12M23/00 , C12M23/40 , C12M33/00 , C12M33/06 , C12M37/02 , C12M41/00
Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
Abstract translation: 提供了一种采样组件，其被配置为耦合到采样源并且在一个或多个时间上促进无菌采样。 此外，采样组件包括具有第一和第二端口的第一导管，其中第一端口被配置为耦合到采样源。 采样组件还包括具有对应的子端口的多个子管道，其中多个子导管中的每一个在相应的连接器接合处可操作地联接到第一导管。 此外，每个子端口与第一导管流体连通。 采样组件还包括多个采样套件和一个或多个抽吸装置。 此外，每个采样套件可操作地耦合到相应子导管的相应子端口。 此外，一个或多个泵送装置可操作地和无菌地联接到第一管道的第二端口。
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公开(公告)号：US20170167228A1
公开(公告)日：2017-06-15
申请号：US14969915
申请日：2015-12-15
Applicant: General Electric Company
Inventor： James Rollins Maughan , Jeremy Daniel Van Dam , Kalpesh Singal , Chengkun Zhang
CPC classification number: E21B43/00
Abstract: A gas vent system for use in a wellbore that includes a substantially horizontal portion is provided. The gas vent system includes a gas vent conduit positioned within the wellbore. The gas vent conduit defining a gas vent intake passage situated within the substantially horizontal portion of the wellbore and configured to facilitate a flow of gaseous substances therethrough. A gas vent valve coupled to the gas vent conduit and situated outside the wellbore. The gas vent valve controls the flow of gaseous substances through the gas vent conduit.
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公开(公告)号：US09587215B2
公开(公告)日：2017-03-07
申请号：US14453683
申请日：2014-08-07
Applicant: General Electric Company
Inventor： Ying Mao , Kenneth Roger Conway , Weston Blaine Griffin , Reginald Donovan Smith , Evelina Roxana Loghin , Vandana Keskar , Chengkun Zhang , Zhipeng Zhang
CPC classification number: C12M33/00 , A01N1/0236 , A01N1/0268 , B01L7/00 , B01L2300/1827 , C12M1/26 , C12M33/04 , C12M41/12 , C12M45/20 , C12M45/22
Abstract: A coupling device configured to form a sample access assembly is provided. The sample access assembly is configured to house a sample. The coupling device includes a heating component and a separating component. Further, the separating component is configured to separate portions of first and second containers that form first and second compartments of the sample access assembly. Moreover, the heating component is configured to heat at least a portion of the sample.
Abstract translation: 提供了构造成形成样品存取组件的联接装置。 样品存取组件被配置为容纳样品。 联接装置包括加热部件和分离部件。 此外，分离部件构造成分离形成样品进入组件的第一和第二隔室的第一和第二容器的部分。 此外，加热部件构造成加热样品的至少一部分。
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公开(公告)号：US20170058252A1
公开(公告)日：2017-03-02
申请号：US14841072
申请日：2015-08-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Reginald Donovan Smith , Kenneth Roger Conway , Anshika Bajaj
CPC classification number: C12M41/22 , C12M21/08 , C12M23/14 , C12M23/38 , C12M23/48 , C12M27/16 , C12M29/24 , C12M41/48 , C12Q3/00
Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
Abstract translation: 提供了用于启动细胞培养的系统和方法。 该系统和方法包括一个包含位于平台表面区域上的热质量的第一外壳。 所述系统和方法包括放置在第一外壳上的包含培养液和气体混合物的第二外壳，使得第一外壳位于第二外壳和平台之间。 所述系统和方法还包括固定在第二外壳上的盖，并且在平台的表面区域上产生第一热能并且从盖产生第二热能。
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Patent Agency Ranking
公开(公告)号：US20160123848A1
公开(公告)日：2016-05-05
申请号：US14529201
申请日：2014-10-31
Applicant: General Electric Company
Abstract: A semi-automated sampling assembly configured for aseptic sampling at one or more instances from a sample source having a biological inoculum is provided. The semi-automated sampling assembly includes a sampling conduit, a recovery conduit, one or more sampling kits, and a pumping device. The sampling conduit includes a first port and a second port, where the first port of the sampling conduit is configured to be operatively coupled to the sample source. Further, the recovery conduit includes a first port and a second port, where the first port of the recovery conduit is configured to be operatively coupled to the sample source. Also, the second port of the recovery conduit is operatively coupled to at least a portion of the sampling conduit. Moreover, the one or more sampling kits are operatively coupled to the sampling conduit, and the pumping device is operatively coupled to the sampling conduit.
Abstract translation: 提供了一种半自动采样组件，其被配置为在具有生物接种物的样品源的一个或多个实例处进行无菌取样。 半自动采样组件包括采样导管，回收管道，一个或多个采样套件以及泵送装置。 采样导管包括第一端口和第二端口，其中采样导管的第一端口被配置为可操作地耦合到采样源。 此外，回收管道包括第一端口和第二端口，其中回收管道的第一端口被配置为可操作地耦合到采样源。 此外，回收管道的第二端口可操作地联接到采样管道的至少一部分。 此外，一个或多个采样套件可操作地耦合到采样导管，并且泵送装置可操作地耦合到采样导管。
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公开(公告)号：US20160053296A1
公开(公告)日：2016-02-25
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
Abstract translation: 提供了一种被配置为耦合到采样源的采样组件。 采样组件被配置为便于在一个或多个实例的时间进行无菌取样。 采样组件包括具有第一端口和第二端口的第一导管，其中第一端口被配置为耦合到采样源，并且其中第二端口被配置为气密密封。 采样组件还包括具有对应子端口的多个子导管，其中多个子导管中的每一个在相应的连接点处可操作地耦合到第一导管，并且其中每个子端口处于流体连通 与第一个导管。 此外，采样组件包括多个采样套件，其中多个采样套件的每个采样套件可操作地连接到相应副导管的相应子端口。
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公开(公告)号：US10465157B2
公开(公告)日：2019-11-05
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
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公开(公告)号：US20190105609A1
公开(公告)日：2019-04-11
申请号：US15726013
申请日：2017-10-05
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kashan Ali Shaikh , Reginald Donovan Smith , Weston Blaine Griffin
Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
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公开(公告)号：US10190950B2
公开(公告)日：2019-01-29
申请号：US14529201
申请日：2014-10-31
Applicant: General Electric Company
Abstract: A semi-automated sampling assembly configured for aseptic sampling at one or more instances from a sample source having a biological inoculum is provided. The semi-automated sampling assembly includes a sampling conduit, a recovery conduit, one or more sampling kits, and a pumping device. The sampling conduit includes a first port and a second port, where the first port of the sampling conduit is configured to be operatively coupled to the sample source. Further, the recovery conduit includes a first port and a second port, where the first port of the recovery conduit is configured to be operatively coupled to the sample source. Also, the second port of the recovery conduit is operatively coupled to at least a portion of the sampling conduit. Moreover, the one or more sampling kits are operatively coupled to the sampling conduit, and the pumping device is operatively coupled to the sampling conduit.
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