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1.发明申请公开(公告)号：US20170080392A1
公开(公告)日：2017-03-23
申请号：US15311477
申请日：2015-05-12
发明人： Patrick Joseph McCloskey , Julia Lam Lee , David Roger Moore , Cathryn Ellen Olsen , MATTHEW JEREMIAH MISNER , Louisa Ruth Carr , Hongyi Zhou
IPC分类号： B01D71/80 , B01D71/68 , C08F293/00 , B01D69/08
CPC分类号： B01D71/80 , A61M1/16 , B01D69/08 , B01D71/40 , B01D71/68 , B01D71/82 , B01D2323/36 , B01D2325/18 , C08F293/00
摘要： A membrane including a block copolymer is presented. The block copolymer includes at least one block A including structural units having a formula (I), and at least one block B including structural units having a formula (II). A hollow-fiber membrane for hemodialysis or hemofiltration, and associated block copolymer are also presented.
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公开(公告)号：US09289730B2
公开(公告)日：2016-03-22
申请号：US13945459
申请日：2013-07-18
发明人： Dhaval Ajit Bhandari , Patrick Joseph McCloskey , Paul Edward Howson , Kristi Jean Narang , William Koros
IPC分类号： B01D53/22 , B01D71/70 , B29D23/00 , B01D69/08 , B01D69/12 , B01D69/14 , B01D71/16 , B01D71/44 , B01D71/68 , B01D71/02
CPC分类号： B01D71/70 , B01D53/228 , B01D69/088 , B01D69/12 , B01D69/148 , B01D71/024 , B01D71/027 , B01D71/16 , B01D71/44 , B01D71/68 , B01D2257/102 , B01D2257/504 , B29D23/00 , B29D23/001 , Y02C10/10
摘要： The invention provides improved hollow fiber membranes having at least two layers, and methods for forming the same. The methods include co-extruding a first composition, a second composition, and a third composition to form a dual layer hollow fiber membrane. The first composition includes a glassy polymer; the second composition includes a polysiloxane; and the third composition includes a bore fluid. The dual layer hollow fiber membranes include a first layer and a second layer, the first layer being a porous layer which includes the glassy polymer of the first composition, and the second layer being a polysiloxane layer which includes the polysiloxane of the second composition.
摘要翻译： 本发明提供了具有至少两层的改进的中空纤维膜及其形成方法。 所述方法包括共挤出第一组合物，第二组合物和第三组合物以形成双层中空纤维膜。 第一组合物包括玻璃状聚合物; 第二组合物包括聚硅氧烷; 并且第三组合物包括孔流体。 双层中空纤维膜包括第一层和第二层，第一层是包含第一组合物的玻璃状聚合物的多孔层，第二层是包含第二组合物的聚硅氧烷的聚硅氧烷层。
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3.发明授权公开(公告)号：US10518227B2
公开(公告)日：2019-12-31
申请号：US15311477
申请日：2015-05-12
发明人： Patrick Joseph McCloskey , Julia Lam Lee , David Roger Moore , Cathryn Ellen Olsen , Matthew Jeremiah Misner , Louisa Ruth Carr , Hongyi Zhou
摘要： A membrane including a block copolymer is presented. The block copolymer includes at least one block A including structural units having a formula (I), and at least one block B including structural units having a formula (II). A hollow-fiber membrane for hemodialysis or hemofiltration, and associated block copolymer are also presented.
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4.发明授权Method for synthesis of N-methyl piperazine diphenolamide and related composition 有权N-甲基哌嗪二酚的合成方法及相关成分公开(公告)号：US09085542B1
公开(公告)日：2015-07-21
申请号：US14303150
申请日：2014-06-12
IPC分类号： C07D295/192
CPC分类号： C07D295/192 , C07D295/185
摘要： A method for synthesis of N-methyl piperazine diphenolamide is presented. The method includes contacting diphenolic acid with N-methyl piperazine to form a reaction mixture; and heating the reaction mixture to form a reaction product including N-methyl piperazine diphenolamide. An associated composition is also presented.
摘要翻译： 提出了合成N-甲基哌嗪二酚酰胺的方法。 该方法包括使二酚酸与N-甲基哌嗪接触以形成反应混合物; 并加热反应混合物以形成包括N-甲基哌嗪二酚酰胺的反应产物。 还提供了相关的组合物。
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公开(公告)号：US20160136589A1
公开(公告)日：2016-05-19
申请号：US14958939
申请日：2015-12-04
CPC分类号： B01D69/02 , B01D67/0011 , B01D69/06 , B01D71/68 , B01D71/76 , B01D71/82 , B01D2323/36 , B01D2325/18 , B01D2325/38
摘要： Provided herein are certain sulfone polymers having zwitterionic functionality and blends thereof which are suitable for preparation of flat sheet membranes. The polymer blends comprise a blend of a first polymer comprising a sulfone polymer having zwitterionic functionality and a second polymer comprising a sulfone polymer.
摘要翻译： 本文提供了具有两性离子官能团的某些砜聚合物及其共混物，其适用于制备平片膜。 聚合物共混物包含包含具有两性离子官能团的砜聚合物的第一聚合物和包含砜聚合物的第二聚合物的共混物。
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6.发明申请ZWITTERION-FUNCTIONALIZED COPOLYMER HOLLOW-FIBER MEMBRANES AND ASSOCIATED METHOD 审中-公开中性官能化共聚物中空纤维膜及相关方法公开(公告)号：US20160136587A1
公开(公告)日：2016-05-19
申请号：US14547306
申请日：2014-11-19
发明人： Patrick Joseph McCloskey , Cathryn Ellen Olsen , Hongyi Zhou , Louisa Ruth Carr , Matthew Jeremiah Misner
CPC分类号： B01D71/68 , A61M1/16 , B01D67/0002 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D71/76 , B01D71/82 , B01D2323/00 , B01D2325/18 , B01D2325/38 , B01D2325/42
摘要： A hollow-fiber membrane is presented. The hollow fiber membrane, includes a copolymer including sulfone structural units having a formula (I) and zwitterion-functionalized structural units having a formula (II). Method of making the hollow-fiber membrane is also presented.
摘要翻译： 介绍了一种中空纤维膜。 中空纤维膜包括具有式（I）的砜结构单元和具有式（II）的两性离子官能化结构单元的共聚物。 还提出了制造中空纤维膜的方法。
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公开(公告)号：US20150053608A1
公开(公告)日：2015-02-26
申请号：US13970965
申请日：2013-08-20
发明人： Gary William Yeager , Julia Lam Lee , Paul Edward Howson , Hongyi Zhou , Cathryn Ellen Olsen , Patrick Joseph McCloskey , Matthew Jeremiah Misner , Louisa Ruth Carr , Daniel Steiger
CPC分类号： B01D71/68 , B01D69/02 , B01D69/08 , B01D71/38 , B01D71/42 , B01D71/76 , B01D2325/02 , B01D2325/36 , C08G65/4006 , C08G75/23
摘要： A membrane including a polyarylnitrile copolymer is presented. The polyarylnitrile copolymer includes structural units having a formula (I) and at least one terminal group having a formula (II): wherein “a” is 0, 1, 2, or 3; “m” is an integer having a value of 35 to 150; R1 is independently at each occurrence a hyrogen atom, a halogen atom, a nitro group, a cyano group, a C1-C12 aliphatic radical, a C3-C12 cycloaliphatic radical, or a C3-C12 aromatic radical; R2 and R3 are independently a C1-C12 aliphatic radical, a C3-C12 cycloaliphatic radical, or a C3-C12 aromatic radical; L is an oxygen atom or a sulfur atom; and Ar is independently at each occurrence a residue of an aromatic diol or a residue of an aromatic dihalide.
摘要翻译： 提出了一种包括聚芳基腈共聚物的膜。 聚芳基腈共聚物包括具有式（I）和至少一个具有式（II）的端基的结构单元：其中“a”为0,1,2或3; “m”为35〜150的整数， R1在每次出现时独立地为氢原子，卤素原子，硝基，氰基，C 1 -C 12脂族基，C 3 -C 12脂环族基或C 3 -C 12芳族基; R2和R3独立地为C1-C12脂族基团，C3-C12脂环族基团或C3-C12芳族基团; L是氧原子或硫原子; 并且Ar在每次出现时独立地是芳族二醇的残基或芳族二卤化物的残基。
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公开(公告)号：US20180292298A1
公开(公告)日：2018-10-11
申请号：US16010183
申请日：2018-06-15
摘要： Provided herein are kit for providing a gamma sterilized aqueous dextran solution that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation while maintaining sufficient molecular weight to act as a red blood cell aggregate. Also provided are methods of use.
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9.发明授权Zwitterion-functionalized block copolymer membranes and associated block copolymer composition 有权两性离子官能化嵌段共聚物膜和相关的嵌段共聚物组成公开(公告)号：US09440198B2
公开(公告)日：2016-09-13
申请号：US14279377
申请日：2014-05-16
发明人： Patrick Joseph McCloskey , Julia Lam Lee , Hongyi Zhou , Cathryn Ellen Olsen , David Roger Moore , Matthew Jeremiah Misner , Louisa Ruth Carr
CPC分类号： B01D71/80 , A61M1/16 , B01D69/08 , B01D71/40 , B01D71/68 , B01D71/82 , B01D2323/36 , B01D2325/18 , C08L81/06
摘要： A membrane including a block copolymer is presented. The block copolymer includes at least one block A including structural units having a formula (I), and at least one block B including structural units having a formula (II). A hollow-fiber membrane for hemodialysis or hemofiltration, and associated block copolymer are also presented.
摘要翻译： 提出了一种包含嵌段共聚物的膜。 嵌段共聚物包括至少一个包含具有式（I）的结构单元的嵌段A和至少一个包含具有式（II）的结构单元的嵌段B。 还提出了用于血液透析或血液滤过的中空纤维膜和相关的嵌段共聚物。
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公开(公告)号：US20150299657A1
公开(公告)日：2015-10-22
申请号：US14254152
申请日：2014-04-16
发明人： Patrick Joseph McCloskey , James Edward Pickett , Gregory Daryll Goddard , Reginald Donovan Smith , Anshika Bajaj
IPC分类号： C12N5/078
CPC分类号： C12N5/0087 , C12N2500/50 , G01N33/491
摘要： Provided herein are gamma stable dextran solutions and kits that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation and maintain sufficient molecular weight to act as a red blood cell aggregant. Further provided are methods of use.
摘要翻译： 本文提供了γ稳定的葡聚糖溶液和试剂盒，其通过使葡聚糖溶液通过暴露于γ辐射而被消毒并且保持足够的分子量以充当红细胞聚集体来提高血液分离的效率。 进一步提供使用的方法。
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