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公开(公告)号：US20240316561A1
公开(公告)日：2024-09-26
申请号：US18579562
申请日：2022-07-29
Inventor： Bolin Fan , Le Gu , Yongjia Gao , Yingying Zhao , Li Yang , Huazhe Liu
IPC: B01L3/00
CPC classification number: B01L3/502792 , B01L2200/06 , B01L2300/0645 , B01L2400/0415
Abstract: Provided are a microfluidic substrate, a microfluidic chip, and an assay device. The microfluidic substrate includes: a base substrate; a conductive layer arranged on the base substrate, patterns of the conductive layer includes one or more electrode patterns and one or more trace patterns, an orthogonal projection of at least a portion of each trace pattern onto the base substrate is on one side of an orthogonal projection of a corresponding electrode pattern onto the base substrate with a minimum spacing of greater than or equal to 4 micrometers from an outer contour of the electrode pattern.
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公开(公告)号：US12257582B2
公开(公告)日：2025-03-25
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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公开(公告)号：US20240261785A1
公开(公告)日：2024-08-08
申请号：US18018795
申请日：2021-12-31
Applicant: BOE Technology Group Co., Ltd.
Inventor： Feifei Li , Bolin Fan , Ce Ning , Zhengliang Li , Hehe Hu , Nianqi Yao , Jiayu He , Jie Huang , Kun Zhao
IPC: B01L3/00
CPC classification number: B01L3/502761 , B01L2200/0647 , B01L2200/12 , B01L2300/0645 , B01L2300/0848 , B01L2400/0415
Abstract: Provided is a micro-nano fluidic substrate, a chip, a preparation method, and a system. The micro-nano fluidic substrate includes: a base; an electrode layer located on the base, the electrode layer includes a first electrode, a second electrode, and a control electrode; and a film layer located on the electrode layer and far away from the base, the film layer includes a groove layer, a nano-channel and a micro-channel, the groove layer includes a first groove, the nano-channel is located in the first groove, an orthographic projection of the nano-channel on the base at least partially coincides with an orthographic projection of the control electrode on the base, and the micro-channel is in communication with the nano-channel, the micro-channel includes a first micro-channel and a second micro-channel, and the first micro-channel is in communication with the first electrode, the second micro-channel is in communication with the second electrode.
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公开(公告)号：US11865538B2
公开(公告)日：2024-01-09
申请号：US16757902
申请日：2019-03-27
Inventor： Wenliang Yao , Nan Zhao , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Bolin Fan
IPC: B01L3/00 , G01N33/487 , H01L27/12
CPC classification number: B01L3/502715 , G01N33/48707 , H01L27/1214 , B01L2300/0645 , B01L2300/0819
Abstract: A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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Patent Agency Ranking
公开(公告)号：US12251698B2
公开(公告)日：2025-03-18
申请号：US17489920
申请日：2021-09-30
Inventor： Qiuxu Wei , Wenliang Yao , Yingying Zhao , Le Gu , Bolin Fan , Yongjia Gao
IPC: B01L3/00
Abstract: The disclosure provides a micro-fluidic chip, and belongs to the field of chip technology. The microfluidic chip provided in the present disclosure includes a plurality of microfluidic units, each microfluidic unit includes an operation region and a transition region located on at least one side of the operation region, the transition regions at adjacent side of two adjacent microfluidic units are disposed opposite to each other. Each microfluidic unit includes: a first substrate; a first electrode layer disposed on the first substrate, the first electrode layer including a plurality of first sub-electrodes located in the operation region and at least one second sub-electrode located in the transition region, and the at least one second sub-electrode configured to drive a droplet to move from one of the plurality of microfluidic units to an adjacent microfluidic unit.
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公开(公告)号：US11583855B2
公开(公告)日：2023-02-21
申请号：US17186186
申请日：2021-02-26
Inventor： Hui Liao , Yingying Zhao , Bolin Fan , Wenliang Yao , Nan Zhao , Le Gu , Yongjia Gao
IPC: B01L3/00 , G01N27/22 , G01N33/577
Abstract: The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US20210187507A1
公开(公告)日：2021-06-24
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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公开(公告)号：US12226775B2
公开(公告)日：2025-02-18
申请号：US17419970
申请日：2020-09-25
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Qiuxu Wei , Yingying Zhao , Wenliang Yao , Bolin Fan , Le Gu , Yongjia Gao
IPC: B01L3/00 , B01F23/00 , B01F23/41 , B01F101/23 , B01L9/00 , B23Q17/24 , C07K14/705 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N21/17 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/64 , G01N21/77 , G01N21/78 , G01N27/414 , G01N30/12 , G01N30/68 , G01N30/70 , G01N30/72 , G01N30/88 , G01N33/00 , G01N33/18 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/74 , G01N35/00 , G01N35/10 , G06T7/00 , G06T7/90 , H10K10/46 , H10K85/00 , H10K85/20
Abstract: An embodiment of the present disclosure provides a microfluidic chip, including: a first substrate; wherein the first substrate includes a first base, a first electrode layer on the first base; the first electrode layer includes a plurality of first electrodes at intervals along a first direction, wherein a cross-sectional shape of the first electrode parallel to the first base is a centrosymmetric shape, and the cross-sectional shape includes: a first boundary and a second boundary opposite to each other in the first direction; a shape of the first boundary is a centrosymmetric curve, a distance between two end points of the first boundary in a second direction perpendicular to the first direction is less than a length of the first boundary; the second boundary has a same shape and length as the first boundary, and the first and second boundaries are parallel to each other in the first direction.
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9.发明公开公开(公告)号：US20240293810A1
公开(公告)日：2024-09-05
申请号：US18024878
申请日：2022-03-15
CPC classification number: B01L3/502715 , B01L3/502746 , G01K7/16
Abstract: The application provides a microfluidic chip, a temperature measurement method using the same, and an analysis device, which relates to the field of microfluidic technology. The microfluidic chip includes: a substrate and at least one microfluidic module located on the substrate, wherein the microfluidic module includes a droplet control unit and at least one temperature detection unit, and wherein the temperature detection unit includes a temperature sensor, a first lead group and a second lead group, the temperature sensor is fixed on the substrate, the first lead group and the second lead group are electrically connected with the temperature sensor respectively, the first lead group is configured to transmit a constant current to the temperature sensor, and the second lead group is configured to electrically connect the temperature sensor and an external voltmeter.
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