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公开(公告)号：US12257582B2
公开(公告)日：2025-03-25
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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公开(公告)号：US11067570B2
公开(公告)日：2021-07-20
申请号：US16095023
申请日：2018-04-23
Inventor： Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu
IPC: G01N33/543 , B01L3/00 , G01N21/78
Abstract: The present disclosure relates to a bio-detection chip and a detection method associated therewith. The bio-detection chip includes an upper substrate, a lower substrate, a reference electrode, a driving electrode, and a first dielectric layer, a first hydrophobic layer, a second hydrophobic layer and a second dielectric layer disposed successively between the reference electrode and the driving electrode. The bio-detection chip further includes a plurality of micro-capsules arranged between the first hydrophobic layer and the second hydrophobic layer. Each micro-capsule encapsulates a plurality of charged microspheres, and surfaces of the charged microspheres have a first biomolecule for specifically binding with a second biomolecule that enters the bio-detection chip so as to give rise to a color change. The charged microspheres move close to the upper substrate when a voltage is applied between the reference electrode and the driving electrode. As such, a result of biomolecule detection may be observed intuitively.
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公开(公告)号：US10801984B2
公开(公告)日：2020-10-13
申请号：US16070396
申请日：2017-12-14
Inventor： Yue Geng , Fengchun Pang , Peizhi Cai , Le Gu
IPC: G01N27/22 , C12Q1/6874 , G01N27/327 , G01N33/487 , G01N15/10 , C12Q1/6825 , G01N27/74
Abstract: A chip substrate, a manufacturing method thereof, a gene sequencing chip, and a gene sequencing method. The chip substrate includes a base substrate; first electrode, located on the base substrate in an array; an insulating layer, located at gaps between two adjacent ones of the first electrodes, and partially covering the two adjacent ones of the first electrodes to form containing spaces being in one-to-one correspondence with the first electrodes; a capacitive dielectric layer, located on a side of the first electrodes away from the base substrate, and located in the containing spaces; and second electrodes, located on a side of the capacitive dielectric layer away from the base substrate, the capacitive dielectric layer includes a first region and a second region, an orthographic projection of the second electrodes on the base substrate is overlapped with an orthographic projection of the first region on the base substrate.
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公开(公告)号：US20190302605A1
公开(公告)日：2019-10-03
申请号：US16171195
申请日：2018-10-25
Inventor： Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che
Abstract: The present disclosure discloses a mask, which includes a first substrate and a second substrate. The mask further includes a polarity particle positioned between the first substrate and the second substrate. The polarity particle has a light absorption or light transmission effect. The first substrate includes a plurality of driving electrodes disposed toward the second substrate and arranged in an array. Each of the driving electrodes is configured to receive an electric signal and control the polarity particle to move to a designated driving electrode to form a pattern.
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公开(公告)号：US20240316561A1
公开(公告)日：2024-09-26
申请号：US18579562
申请日：2022-07-29
Inventor： Bolin Fan , Le Gu , Yongjia Gao , Yingying Zhao , Li Yang , Huazhe Liu
IPC: B01L3/00
CPC classification number: B01L3/502792 , B01L2200/06 , B01L2300/0645 , B01L2400/0415
Abstract: Provided are a microfluidic substrate, a microfluidic chip, and an assay device. The microfluidic substrate includes: a base substrate; a conductive layer arranged on the base substrate, patterns of the conductive layer includes one or more electrode patterns and one or more trace patterns, an orthogonal projection of at least a portion of each trace pattern onto the base substrate is on one side of an orthogonal projection of a corresponding electrode pattern onto the base substrate with a minimum spacing of greater than or equal to 4 micrometers from an outer contour of the electrode pattern.
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Patent Agency Ranking
公开(公告)号：US11708604B2
公开(公告)日：2023-07-25
申请号：US16486038
申请日：2018-12-24
Inventor： Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Chuncheng Che
IPC: C12Q1/68 , G03F7/00 , C12Q1/6869
CPC classification number: C12Q1/6869 , G03F7/0002
Abstract: A gene sequencing substrate and a method for manufacturing the same, and a gene sequencing device are provided. It belongs to the technical field of gene sequencing, and can solve the problem of high cost of the high-throughput sequencing chip in the prior art. The gene sequencing substrate of the present disclosure comprises a plastic material with concave structures as base substrate, and the concave structures serve as reaction cells. Since the base substrate has plasticity, the concave structures can be formed by a simple process to reduce the cost of the gene sequencing substrate. Meanwhile, a first protective layer may be provided on the inner wall of the concave structures for preventing the inner wall of the concave structures from being corroded by the reaction liquid.
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公开(公告)号：US11684916B2
公开(公告)日：2023-06-27
申请号：US16632934
申请日：2019-01-09
Inventor： Wenliang Yao , Nan Zhao , Haochen Cui , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Chuncheng Che
CPC classification number: B01L3/502715 , C12Q1/686 , B01L2300/0645 , B01L2300/1827
Abstract: A chip for polymerase chain reaction, a method of operating a chip for polymerase chain reaction, and a reaction device are provided. The chip includes: a sample adding region, a mixing region, a temperature cycling region in a sequential arrangement, and at least one driving unit group. The at least one driving unit group includes a plurality of driving units and is configured to drive a liquid drop to move and sequentially pass through the sample adding region, the mixing region, and the temperature cycling region.
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公开(公告)号：US11351547B2
公开(公告)日：2022-06-07
申请号：US16610318
申请日：2019-03-26
Inventor： Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che , Nan Zhao
IPC: B01L3/00
Abstract: Micro-fluidic chip comprises substrate and plurality of driving circuits on substrate, each of plurality of driving circuits comprising: driving electrode comprising first electrode plate and second electrode plate made of different materials on substrate, first electrode plate being electrically coupled to second electrode plate; and detecting sub-circuit comprising first signal terminal electrically coupled to first electrode plate and second signal terminal electrically coupled to second electrode plate, wherein micro-fluidic chip further comprises: voltage supply sub-circuit configured to supply driving voltage to first signal terminal to control droplet to move toward driving circuit during droplet driving stage, and configured to supply constant voltage to first signal terminal, during temperature detecting stage, and wherein detecting sub-circuit is configured to measure voltage difference between first signal terminal and second signal terminal, and obtain temperature of droplet on second electrode plate according to voltage difference, during temperature detecting stage.
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公开(公告)号：US20210331162A1
公开(公告)日：2021-10-28
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US12226775B2
公开(公告)日：2025-02-18
申请号：US17419970
申请日：2020-09-25
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Qiuxu Wei , Yingying Zhao , Wenliang Yao , Bolin Fan , Le Gu , Yongjia Gao
IPC: B01L3/00 , B01F23/00 , B01F23/41 , B01F101/23 , B01L9/00 , B23Q17/24 , C07K14/705 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N21/17 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/64 , G01N21/77 , G01N21/78 , G01N27/414 , G01N30/12 , G01N30/68 , G01N30/70 , G01N30/72 , G01N30/88 , G01N33/00 , G01N33/18 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/74 , G01N35/00 , G01N35/10 , G06T7/00 , G06T7/90 , H10K10/46 , H10K85/00 , H10K85/20
Abstract: An embodiment of the present disclosure provides a microfluidic chip, including: a first substrate; wherein the first substrate includes a first base, a first electrode layer on the first base; the first electrode layer includes a plurality of first electrodes at intervals along a first direction, wherein a cross-sectional shape of the first electrode parallel to the first base is a centrosymmetric shape, and the cross-sectional shape includes: a first boundary and a second boundary opposite to each other in the first direction; a shape of the first boundary is a centrosymmetric curve, a distance between two end points of the first boundary in a second direction perpendicular to the first direction is less than a length of the first boundary; the second boundary has a same shape and length as the first boundary, and the first and second boundaries are parallel to each other in the first direction.
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