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公开(公告)号：US5017292A
公开(公告)日：1991-05-21
申请号：US521784
申请日：1990-05-10
CPC分类号： B01D61/145 , A61L2/0017 , A61L2/022 , B01D61/142 , B01D69/02 , B01D69/12 , C07K1/34
摘要： A composite membrane and process utilizing the membrane which is capable of selectively removing particles such as viral particles from a solution such as a protein solution is provided. The membrane comprises a porous membrane substrate, a surface skin having ultrafiltration separation properties and an intermediate porous zone between the substrate and the skin which intermediate zone has an average pore size smaller than that of the substrate. The intermediate zone is free of voids which break the skin and which directly fluid communicate with the substrate. The composite is capable of a log reduction value of at least 3 (99.9% removal) of particles selectively from solution.
摘要翻译： 提供一种复合膜和利用该膜的方法，其能够从诸如蛋白质溶液的溶液中选择性地除去诸如病毒颗粒的颗粒。 膜包括多孔膜基底，具有超滤分离性能的表面皮肤和在基底和皮肤之间的中间多孔区，该中间区的平均孔径小于基底的平均孔径。 中间区域没有空隙，其破坏皮肤并且与基底直接流体连通。 复合材料能够从溶液中选择性地减少至少3（99.9％去除）颗粒的对数减少值。
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公开(公告)号：US5096637A
公开(公告)日：1992-03-17
申请号：US623856
申请日：1990-12-05
CPC分类号： B01D61/145 , A61L2/0017 , A61L2/022 , B01D61/142 , B01D69/02 , B01D69/12 , C07K1/34 , Y10S264/48 , Y10S264/62
摘要： A composite membrane and process utilizing the membrane which is capable of selectively removing particles such as viral particles from a solution such as a protein solution is provided. The membrane comprises a porous membrane substrate, a surface skin having ultrafiltration separation properties and an intermediate porous zone between the substrate and the skin which intermediate zone has an average pore size smaller than that of the substrate. The intermediate zone is free of voids which break the skin and which directly fluid communicate with the substrate. The composite is capable of a log reduction value of at least 3 (99.9% removal) of particles selectively from solution.
摘要翻译： 提供一种复合膜和利用该膜的方法，其能够从诸如蛋白质溶液的溶液中选择性地除去诸如病毒颗粒的颗粒。 膜包括多孔膜基底，具有超滤分离性能的表面皮肤和在基底和皮肤之间的中间多孔区，该中间区的平均孔径小于基底的平均孔径。 中间区域没有空隙，其破坏皮肤并且与基底直接流体连通。 复合材料能够从溶液中选择性地减少至少3（99.9％去除）颗粒的对数减少值。
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公开(公告)号：US06447684B2
公开(公告)日：2002-09-10
申请号：US09855311
申请日：2001-05-14
IPC分类号： B01D6114
CPC分类号： B01D67/0093 , B01D61/00 , B01D61/14 , B01D2323/30 , B01J45/00 , C02F1/44 , C02F1/683 , C02F2101/20 , Y10S210/90
摘要： The invention pertains to a method for simultaneously removing metallic ions and particulate material from a pH neutral solution using particle-removing membranes (e.g., ultra high molecular weight polyethylene) having immobilized ligands that possess the capacity and high equilibrium binding constants for ion removal. The method is particularly useful for simultaneously filtering/purifying deionized water.
摘要翻译： 本发明涉及一种使用具有固定化配体的除去微粒的膜（例如超高分子量聚乙烯）从pH中性溶液中除去金属离子和颗粒材料的方法，所述固定化配体具有用于离子去除的能力和高平衡结合常数。 该方法对于同时过滤/净化去离子水特别有用。
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公开(公告)号：US5339675A
公开(公告)日：1994-08-23
申请号：US958384
申请日：1992-10-08
申请人： Anthony J. DiLeo , James T. Snow , Daniel A. Cote
发明人： Anthony J. DiLeo , James T. Snow , Daniel A. Cote
IPC分类号： G01N5/02 , G01N27/00 , G01N29/00 , G01N29/02 , G01N29/036
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/014 , G01N2291/0256 , G01N2291/02809 , G01N2291/02845 , G01N2291/0423 , G01N2291/0426
摘要： A device is provided comprising a piezoelectric material and at least one coating reactive with trace quantities of oxygen and/or water in reactive and inert gases. The piezoelectric material is bonded to a conductor for delivering an alternating electric current and to a conductor for transmitting resonant vibration frequency of the crystal. The reactive coating has an effective thickness which provides a serviceable life for the coating while not being so thick as to prevent vibration of the piezoelectric material.
摘要翻译： 提供了一种装置，其包括压电材料和至少一种在反应性和惰性气体中与微量氧和/或水反应的涂层。 压电材料结合到用于传递交流电的导体和用于传输晶体的谐振频率的导体。 反应性涂层具有有效的厚度，其为涂层提供可使用的寿命，同时不会如此厚以致于防止压电材料的振动。
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公开(公告)号：US5282380A
公开(公告)日：1994-02-01
申请号：US906730
申请日：1992-06-30
CPC分类号： B01D65/102 , G01N15/0826 , G01N2015/086
摘要： A process is provided for rapidly and non-destructively evaluating the particle retention characteristics of porous membranes using a novel liquid-porosimetric technique. A ratio of two membrane permeabilities is measured at preselected operating conditions using a pair of mutually immiscible fluids, one of which is employed as a membrane wetting agent and the other used as an intrusion fluid. The first operating condition, a particular transmembrane pressure, is chosen so as to selectively intrude those pores accessible to a given sized particle, such as a virus. The second operating condition, either a second preselected transmembrane pressure or a water permeability measurement, is chosen such that nearly all of the membrane pores are intruded. The ratio of the two permeabilities obtained with each set of operating conditions is thus the percentage of total flow through the membrane pores accessible to a given sized particle. By experimentally measuring this permeability ratio on membranes with known particle retention behavior, a calibration curve relating the permeability ratio to the particle retention characteristics can be constructed. From this standard correlation, the particle retention capabilities of an unchallenged membrane can be predicted in a non-destructive manner solely by measuring its permeability ratio.
摘要翻译： 提供了使用新的液体 - 孔隙率法快速且非破坏性地评估多孔膜的颗粒保留特性的方法。 使用一对相互混溶的流体在预选的操作条件下测量两个膜渗透性的比例，其中一种用作膜润湿剂，另一种用作侵入流体。 选择第一操作条件，特定的跨膜压力，以便选择性地侵入给定大小的颗粒例如病毒可接近的那些孔。 选择第二操作条件，即第二预选跨膜压力或透水性测量，使得几乎所有的膜孔都被侵入。 因此，通过每组操作条件获得的两个渗透率的比例是通过给定尺寸颗粒可接近的膜孔的总流量的百分比。 通过实验测量具有已知颗粒保留行为的膜的渗透率比，可以构建将渗透率与颗粒保持特性相关联的校准曲线。 从这个标准的相关性，单独通过测量其渗透率比，无损检测的膜的颗粒保留能力可以非破坏性地预测。
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公开(公告)号：US06524482B2
公开(公告)日：2003-02-25
申请号：US09838664
申请日：2001-04-19
IPC分类号： B01D6100
CPC分类号： B01D67/0088 , B01D15/00 , B01D61/00 , B01D67/0093 , B01D69/141 , B01D2323/30 , B01J20/3219 , B01J20/3242 , B01J45/00
摘要： The present invention provides methods for removing species of ions from biological solutions, thereby allowing controlled study of the biological effect of one or more ion on a biological system or environment. In general, a solution from which one or more ion species are to be removed is contacted with an ion binding ligand having an affinity for the desired ion wherein the ligand is bound to a substrate such as a solid support or membrane. After the ions have been bound by the ligand-substrate composition, the composition having the ions bound thereto is removed, leaving a solution with a reduced concentration of the one or more ions which were targeted. The biological solution may then be compared to a control biological solution in its original state, or ions may added back into the depleted biological solution at known concentrations. Under either scenario, the biological effects of one or more ions may be studied.
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公开(公告)号：US4728430A
公开(公告)日：1988-03-01
申请号：US828105
申请日：1986-02-10
CPC分类号： A61M1/3472 , A61M1/3482 , A61M2205/7563
摘要： A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation: ##EQU1## called Equation 1.
摘要翻译： 提供了一种将患者的全血分离为细胞成分和血浆成分并将血浆成分分离成高分子量血浆级分和低分子量血浆级分的方法和装置，其中将抗凝血剂加入到全血中 并将生理上可接受的液体稀释剂加入到血浆组分中。 稀释剂的添加速度由以下等式控制：
+ TR 称为等式1。 -
公开(公告)号：US20110049042A1
公开(公告)日：2011-03-03
申请号：US12925915
申请日：2010-11-02
申请人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
发明人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
IPC分类号： B01D15/00
CPC分类号： B01D15/20 , B01D15/265 , B01D15/361 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J2220/54 , B01J2220/58 , B01J2220/62
摘要： A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.
摘要翻译： 能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。 所得到的底物具有良好的对流和扩散流量和容量。 底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。
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公开(公告)号：US07479223B2
公开(公告)日：2009-01-20
申请号：US11050004
申请日：2005-02-03
申请人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
发明人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/28078 , B01J20/28085 , B01J20/3035 , B01J20/305 , B01J20/321 , B01J20/3251 , B01J20/3274 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J2220/62 , B01J2220/82
摘要： A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be crosslinked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.
摘要翻译： 能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附性涂层的多孔基材，其包含基材孔隙体积的约1至约80％。 所得到的底物具有良好的对流和扩散流量和容量。 底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。
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公开(公告)号：US07479222B2
公开(公告)日：2009-01-20
申请号：US11049803
申请日：2005-02-03
申请人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
发明人： Anthony J. DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil P. Soice , Volkmar Thom , Sarah Yuan
IPC分类号： B01D15/08
CPC分类号： B01D15/20 , B01D15/265 , B01D15/361 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J2220/54 , B01J2220/58 , B01J2220/62
摘要： A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.
摘要翻译： 能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。 所得到的底物具有良好的对流和扩散流量和容量。 底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。
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