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公开(公告)号：US20240197859A1
公开(公告)日：2024-06-20
申请号：US18553308
申请日：2022-03-31
发明人： Johannes Petrus Maria Langedijk , Mark Johannes Gerardus Bakkers , Tina Ritschel , Jaroslaw Juraszek
IPC分类号： A61K39/155 , A61K39/00 , C07K14/005 , C12N7/00 , C12N15/86
CPC分类号： A61K39/155 , C07K14/005 , C12N7/00 , C12N15/86 , A61K2039/53 , C07K2319/35 , C12N2710/10343 , C12N2760/18622 , C12N2760/18634
摘要： The present invention relates to stabilized pre-fusion human parainfluenza virus 3 (HPIV3) F protein, and fragments thereof. The invention also relates to nucleic acid molecules encoding such proteins and fragments, and to the use of the proteins, fragments and nucleic acid molecules.
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公开(公告)号：US20240091102A1
公开(公告)日：2024-03-21
申请号：US17754877
申请日：2020-10-16
发明人： Olga Labovitiadi , Martinus Anne Hobbe Capelle , Joao Miguel Calado Da Silva Freire , Willem Jan Timmer
IPC分类号： A61J1/14 , A61K39/13 , A61K39/235
CPC分类号： A61J1/1468 , A61K39/13 , A61K39/235 , A61K2039/5254
摘要： The present invention provides a vaccine product comprising a container, wherein the container comprises an internal surface, the internal surface comprising either (i) silicon dioxide, (ii) a polymeric material, or (iii) a surface treated with ethylene oxide; and a vaccine composition within the container in contact with the internal surface, wherein the vaccine composition comprises virus particles.
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公开(公告)号：US11872281B2
公开(公告)日：2024-01-16
申请号：US16760269
申请日：2018-10-30
IPC分类号： C12N15/00 , A61K39/235 , C12N15/86
CPC分类号： A61K39/235 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10342 , C12N2710/10343
摘要： Provided herein are adenoviral nucleic acid sequences and adenoviral vectors comprising said nucleic acid sequences. The provided adenoviral vectors can be used to induce a protective immune response in a subject.
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公开(公告)号：US20230310573A1
公开(公告)日：2023-10-05
申请号：US17995158
申请日：2021-04-01
发明人： Tina RITSCHEL , Richard VOORZAAT , Lucy RUTTEN , Mandy Antonia Catharina JONGENEELEN , Tim Hugo Maria JONCKERS , Dirk André Emmy ROYMANS , Johannes Petrus Maria LANGEDIJK
IPC分类号： A61K39/145 , A61P31/12
CPC分类号： A61K39/145 , A61P31/12 , A61K2039/545
摘要： The present invention relates to vaccine composition comprising an immunologically effective amount of a viral fusion protein antigen, such as an RSV pre-fusion F protein, and a stabilizing amount of an antiviral compound, and to methods for preparing such vaccine compositions.
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公开(公告)号：US20230233661A1
公开(公告)日：2023-07-27
申请号：US18003547
申请日：2021-06-29
发明人： Benoit Christophe Stephan CALLENDRET , Els DE PAEPE , Christy Ann COMEAUX , Roland Christian ZAHN , Esther Mathilde Eugene Wilhelmus HEIJNEN
IPC分类号： A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： A61K39/155 , A61P31/14 , C12N2760/18534 , A61K2039/53 , C12N2710/10043 , A61K2039/54 , A61K2039/545
摘要： Methods of safely inducing a protective immune response against respiratory syncytial virus (RSV) and methods of preventing infection and/or replication of RSV in human subjects are described. The methods include administering to the subjects (a) an effective amount of an adenoviral vector encoding a recombinant RSV F protein that is stabilized in a pre-fusion conformation, and (b) an effective amount of an RSV F protein that is stabilized in a pre-fusion conformation.
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公开(公告)号：US11603390B2
公开(公告)日：2023-03-14
申请号：US17266404
申请日：2019-08-13
发明人： Johannes Langedijk , Lucy Rutten , Sven Blokland
IPC分类号： A61K39/12 , C07K14/005
摘要： Filovirus glycoprotein mutations that stabilize the trimeric form of the glycoprotein are provided. The Filovirus glycoproteins have certain amino acid substitutions at specified positions in the glycoprotein sequence. The Filovirus glycoproteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to a Filovirus glycoprotein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the Filovirus glycoproteins, as well as compositions containing the Filovirus glycoproteins, nucleic acid, and vectors.
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公开(公告)号：US11472869B2
公开(公告)日：2022-10-18
申请号：US16514770
申请日：2019-07-17
发明人： Jehangir Wadia , Gabriel Pascual , Robert Anthony Williamson , Katarina Radosevic , Jaap Goudsmit
IPC分类号： C07K16/18 , A61K39/395 , G01N33/68
摘要： The invention relates to antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using anti-tau antibodies.
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公开(公告)号：US11459583B2
公开(公告)日：2022-10-04
申请号：US16760565
申请日：2018-10-30
IPC分类号： C12N15/86 , A61K39/235 , C07K14/005 , C12N7/00 , A61K39/00
摘要： Provided herein are chimeric adenoviral vectors. The provided chimeric adenoviral vectors can be used to induce a protective immune response in a subject.
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公开(公告)号：US20220273787A1
公开(公告)日：2022-09-01
申请号：US17595255
申请日：2020-05-14
摘要： Methods of inducing a protective immune response against respiratory syncytial virus (RSV) and against influenza virus, without inducing a severe adverse event in human subjects are described. The methods include administering to the subjects an effective amount of an adenoviral vector encoding a recombinant RSV F polypeptide that is stabilized in a pre-fusion conformation, along with an effective amount of an influenza vaccine.
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10.发明申请公开(公告)号：US20220096622A1
公开(公告)日：2022-03-31
申请号：US17457705
申请日：2021-12-06
发明人： Dan BAROUCH , Johanna SCHUITEMAKER , Maria Grazia PAU , Danielle VAN MANEN , Frank TOMAKA , Jennifer Anne HENDRIKS
IPC分类号： A61K39/21 , C07K14/005 , C12N15/86 , A61K39/12 , C12N7/00
摘要： Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
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