公开(公告)号：US09969778B2

公开(公告)日：2018-05-15

申请号：US15253535

申请日：2016-08-31

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jan Willem Meijberg ,  Antonietta Impagliazzo ,  Ronald Vogels ,  Robert H. E. Friesen ,  Philippe Alard ,  Stefan Loverix ,  Katarina Radosevic

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  C07K16/10 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/55522 ,  A61K2039/575 ,  C07K16/1018 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/73 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171

摘要： The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.

公开(公告)号：US10117925B2

公开(公告)日：2018-11-06

申请号：US15324939

申请日：2015-07-09

申请人： Janssen Vaccines & Prevention B.V.

发明人： Antonietta Impagliazzo ,  Jan Willem Meijberg ,  Katarina Radosevic ,  Michelle Wagner ,  Zhaoqing Ding

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/145 ,  A61K39/12 ,  C12N7/00 ,  C07K14/11

摘要： Provided herein are multimeric influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

公开(公告)号：US10517941B2

公开(公告)日：2019-12-31

申请号：US14952794

申请日：2015-11-25

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jan Willem Meijberg ,  Antonietta Impagliazzo ,  Katarina Radosevic ,  Jehangir Wadia ,  Robert Anthony Williamson ,  Michelle Wagner ,  Zhaoqing Ding

IPC分类号： A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

摘要： Provided are influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment comprising the amino acids from position 1 to position x, preferably from position p to position x, of the HA1 domain, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, comprising the amino acids from position y to and including the C-terminal amino acid of the HA1 domain; and (b) an influenza hemagglutinin HA2 domain, wherein the hemagglutinin stem domain polypeptide is resistant to protease cleavage at the junction between HA1 and HA2, and wherein one or more amino acid of the amino acids at positions 337, 340, 352, 353, 402, 406, 409, 413 and/or 416 have been mutated, as compared to the corresponding positions in wild-type influenza HA.

公开(公告)号：US10111944B2

公开(公告)日：2018-10-30

申请号：US15324964

申请日：2015-07-09

申请人： Janssen Vaccines & Prevention B.V.

发明人： Antonietta Impagliazzo ,  Jan Willem Meijberg ,  Katarina Radosevic ,  Michelle Wagner ,  Zhaoqing Ding

IPC分类号： A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C07K14/11 ,  A61K39/12 ,  C07K16/10 ,  A61K39/00

摘要： Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

公开(公告)号：US20160362455A1

公开(公告)日：2016-12-15

申请号：US15253535

申请日：2016-08-31

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jan Willem Meijberg ,  Antonietta Impagliazzo ,  Ronald Vogels ,  Robert H.E. Friesen ,  Philippe Alard ,  Stefan Loverix ,  Katarina Radosevic

IPC分类号： C07K14/005 ,  A61K39/145 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/55522 ,  A61K2039/575 ,  C07K16/1018 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/73 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171

摘要： The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.

公开(公告)号：US11472869B2

公开(公告)日：2022-10-18

申请号：US16514770

申请日：2019-07-17

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jehangir Wadia ,  Gabriel Pascual ,  Robert Anthony Williamson ,  Katarina Radosevic ,  Jaap Goudsmit

IPC分类号： C07K16/18 ,  A61K39/395 ,  G01N33/68

摘要： The invention relates to antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using anti-tau antibodies.

公开(公告)号：US10400034B2

公开(公告)日：2019-09-03

申请号：US15321918

申请日：2015-06-26

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jehangir Wadia ,  Gabriel Pascual ,  Robert Anthony Williamson ,  Katarina Radosevic ,  Jaap Goudsmit

IPC分类号： C07K16/18 ,  G01N33/68

摘要： The disclosure relates to antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The disclosure also relates to diagnostic, prophylactic and therapeutic methods using anti-tau antibodies.

公开(公告)号：US10328144B2

公开(公告)日：2019-06-25

申请号：US16141161

申请日：2018-09-25

申请人： Janssen Vaccines & Prevention B.V.

发明人： Antonietta Impagliazzo ,  Jan Willem Meijberg ,  Katarina Radosevic ,  Michelle Wagner ,  Zhaoqing Ding

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C07K16/10 ,  C07K14/11

摘要： Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

公开(公告)号：US20170152307A1

公开(公告)日：2017-06-01

申请号：US15321918

申请日：2015-06-26

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jehangir Wadia ,  Gabriel Pascual ,  Robert Anthony Williamson ,  Katarina Radosevic ,  Jaap Goudsmit

IPC分类号： C07K16/18 ,  G01N33/68

CPC分类号： C07K16/18 ,  A61K39/395 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/94 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2800/2821

摘要： The disclosure relates to antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The disclosure also relates to diagnostic, prophylactic and therapeutic methods using anti-tau antibodies.

公开(公告)号：US20160355553A1

公开(公告)日：2016-12-08

申请号：US15243738

申请日：2016-08-22

申请人： Janssen Vaccines & Prevention B.V.

发明人： Jan Willem Meijberg ,  Antonietta Impagliazzo ,  Ronald Vogels ,  Robert H.E. Friesen ,  Philippe Alard ,  Stefan Loverix ,  Katarina Radosevic

IPC分类号： C07K14/005 ,  C12N7/00 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/55522 ,  A61K2039/575 ,  C07K16/1018 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/73 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171

摘要： The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.

摘要翻译： 本公开提供流感血凝素干结构域多肽，其包含（a）流感血凝素HA1结构域，其包含通过0-50个氨基酸残基的连接序列与HA1 C-末端茎段共价连接的HA1N末端茎段， 和（b）流感血凝素HA2结构域，其中在HA2结构域中的多个氨基酸已被突变。 还提供了编码多肽的核酸，包含多肽和/或核酸分子的组合物，以及它们用途的方法，特别是在流感的检测，预防和/或治疗中。