专利检索 ap:("Janssen Vaccines & Prevention B.V.") AND inv:"Esther Mathilde Eugene Wilhelmus HEIJNEN" 第 1 页

1.

发明公开
VACCINE COMBINATION AGAINST REPIRATORY SYNCYTIAL VIRUS INFECTION 审中-公开

公开(公告)号：US20230233661A1

公开(公告)日：2023-07-27

申请号：US18003547

申请日：2021-06-29

申请人： Janssen Vaccines & Prevention B.V.

发明人： Benoit Christophe Stephan CALLENDRET , Els DE PAEPE , Christy Ann COMEAUX , Roland Christian ZAHN , Esther Mathilde Eugene Wilhelmus HEIJNEN

IPC分类号： A61K39/155 , A61P31/14 , A61K39/00

CPC分类号： A61K39/155 , A61P31/14 , C12N2760/18534 , A61K2039/53 , C12N2710/10043 , A61K2039/54 , A61K2039/545

摘要： Methods of safely inducing a protective immune response against respiratory syncytial virus (RSV) and methods of preventing infection and/or replication of RSV in human subjects are described. The methods include administering to the subjects (a) an effective amount of an adenoviral vector encoding a recombinant RSV F protein that is stabilized in a pre-fusion conformation, and (b) an effective amount of an RSV F protein that is stabilized in a pre-fusion conformation.