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公开(公告)号：US20230233661A1
公开(公告)日：2023-07-27
申请号：US18003547
申请日：2021-06-29
发明人： Benoit Christophe Stephan CALLENDRET , Els DE PAEPE , Christy Ann COMEAUX , Roland Christian ZAHN , Esther Mathilde Eugene Wilhelmus HEIJNEN
IPC分类号： A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： A61K39/155 , A61P31/14 , C12N2760/18534 , A61K2039/53 , C12N2710/10043 , A61K2039/54 , A61K2039/545
摘要： Methods of safely inducing a protective immune response against respiratory syncytial virus (RSV) and methods of preventing infection and/or replication of RSV in human subjects are described. The methods include administering to the subjects (a) an effective amount of an adenoviral vector encoding a recombinant RSV F protein that is stabilized in a pre-fusion conformation, and (b) an effective amount of an RSV F protein that is stabilized in a pre-fusion conformation.
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公开(公告)号：US20210353744A1
公开(公告)日：2021-11-18
申请号：US17317580
申请日：2021-05-11
IPC分类号： A61K39/295 , A61P31/20
摘要： Compositions comprising a recombinant adenovirus of type Ad26 comprising a polynucleotide that encodes an antigen, kits of parts and methods of using these compositions for inducing an immune response in a subject are provided.
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公开(公告)号：US20200093917A1
公开(公告)日：2020-03-26
申请号：US16579193
申请日：2019-09-23
IPC分类号： A61K39/21 , C12N15/861 , C12N15/113
摘要： Methods of inducing an immune response against human immunodeficiency virus (HIV) are described. In particular, methods of inducing an immune response against HIV by co-locally administering an immunogenically effective amount of an isolated HIV envelope (Env) polypeptide and an immunogenically effective amount of an adenovirus vector encoding an HIV antigen, e.g., Env antigen are described. The isolated HIV Env polypeptide and adenovirus vector can be administered in a single composition or in separate compositions, in which the composition or compositions do not contain an adjuvant.
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