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公开(公告)号：US20230310573A1
公开(公告)日：2023-10-05
申请号：US17995158
申请日：2021-04-01
发明人： Tina RITSCHEL , Richard VOORZAAT , Lucy RUTTEN , Mandy Antonia Catharina JONGENEELEN , Tim Hugo Maria JONCKERS , Dirk André Emmy ROYMANS , Johannes Petrus Maria LANGEDIJK
IPC分类号： A61K39/145 , A61P31/12
CPC分类号： A61K39/145 , A61P31/12 , A61K2039/545
摘要： The present invention relates to vaccine composition comprising an immunologically effective amount of a viral fusion protein antigen, such as an RSV pre-fusion F protein, and a stabilizing amount of an antiviral compound, and to methods for preparing such vaccine compositions.
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公开(公告)号：US20240132548A1
公开(公告)日：2024-04-25
申请号：US18546798
申请日：2022-02-18
IPC分类号： C07K14/005 , A61P37/04 , C12N15/86
CPC分类号： C07K14/005 , A61P37/04 , C12N15/86 , C12N2710/10043
摘要： The present invention provides stable pre-fusion respiratory syncytial virus (RSV) FB proteins, nucleic acid molecules and vectors encoding such proteins, and compositions comprising said proteins, nucleic acid molecules and/or vectors, and uses thereof for the prevention and/or treatment of RSV infection.
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公开(公告)号：US20230250135A1
公开(公告)日：2023-08-10
申请号：US17753506
申请日：2020-09-03
发明人： Mandy Antonia Catharina JONGENEELEN , Tina RITSCHEL , Ferdinand Jacobus MILDER , Indigo KING , Yifan SONG , Johannes Petrus Maria LANGEDIJK , Boerries BRANDENBURG
IPC分类号： C07K14/005 , A61P31/16
CPC分类号： C07K14/005 , A61P31/16 , C07K2319/42 , A61K39/00
摘要： Provided herein are group 2 influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
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公开(公告)号：US20240228548A9
公开(公告)日：2024-07-11
申请号：US18546798
申请日：2022-02-18
IPC分类号： C07K14/005 , A61P37/04 , C12N15/86
CPC分类号： C07K14/005 , A61P37/04 , C12N15/86 , C12N2710/10043
摘要： The present invention provides stable pre-fusion respiratory syncytial virus (RSV) FB proteins, nucleic acid molecules and vectors encoding such proteins, and compositions comprising said proteins, nucleic acid molecules and/or vectors, and uses thereof for the prevention and/or treatment of RSV infection.
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公开(公告)号：US20230312654A1
公开(公告)日：2023-10-05
申请号：US17754922
申请日：2020-10-15
发明人： Boerries BRANDENBURG , Johannes Petrus Maria LANGEDIJK , Tina RITSCHEL , Ferdinand Jacobus MILDER , Mandy Antonia Catharina JONGENEELEN
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/00
摘要： Provided herein are isolated mutant influenza hemagglutinin polypeptides, methods for providing isolated mutant hemagglutinin polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.
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公开(公告)号：US20220204567A1
公开(公告)日：2022-06-30
申请号：US17594576
申请日：2020-04-23
发明人： Boerries BRANDENBURG , Tina RITSCHEL , Ferdinand Jacobus MILDER , Mandy Antonia, Catharina JONGENEELEN , Indigo KING , Yifan SONG , Johannes Petrus, Maria LANGEDIJK
IPC分类号： C07K14/005
摘要： The invention provides recombinant influenza A hemagglutinin (HA) polypeptides, comprising an HA1 and a HA2 domain of an influenza A virus HA, and comprising an amino acid sequence wherein: (a) the amino acid at position 355 is W; and (b) the amino acid at position 432 is I and/or the amino acid at position 380 is I; and wherein the numbering of the amino acid positions in the amino acid sequence of the HA polypeptide is according to the numbering of amino acids in the amino acid sequence of HA from a reference H3N2 influenza strain, in particular the reference strain H3N2 A/Aichi/2/68 (SEQ ID NO: 1), immunogenic fragments thereof, nucleic acid molecules encoding said polypeptides or immunogenic fragments, and uses thereof.
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公开(公告)号：US20200377555A1
公开(公告)日：2020-12-03
申请号：US16964089
申请日：2019-01-22
发明人： Ferdinand Jacobus MILDER , Tina RITSCHEL , Boerries BRANDENBURG , Mandy Antonia Catharina JONGENEELEN , Daphné TRUAN , Johannes Petrus Maria LANGEDIJK
IPC分类号： C07K14/005 , C12N7/00 , A61K39/145 , A61P31/16
摘要： Provided herein are influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
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