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公开(公告)号：US11603390B2
公开(公告)日：2023-03-14
申请号：US17266404
申请日：2019-08-13
发明人： Johannes Langedijk , Lucy Rutten , Sven Blokland
IPC分类号： A61K39/12 , C07K14/005
摘要： Filovirus glycoprotein mutations that stabilize the trimeric form of the glycoprotein are provided. The Filovirus glycoproteins have certain amino acid substitutions at specified positions in the glycoprotein sequence. The Filovirus glycoproteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to a Filovirus glycoprotein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the Filovirus glycoproteins, as well as compositions containing the Filovirus glycoproteins, nucleic acid, and vectors.
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公开(公告)号：US10456462B2
公开(公告)日：2019-10-29
申请号：US15742249
申请日：2016-07-07
IPC分类号： A61K39/155 , A61K39/12 , C07K14/005 , A61P31/14
摘要： Compositions including a recombinant respiratory syncitial virus (RSV) Fusion (F) polypeptide that is stabilized in the pre-fusion conformation are described. The RSV F polypeptide includes at least one mutation as compared to a wild type RSV F polypeptide and the at least one mutation is a) a mutation of the amino acid aspartic acid (D) on position 486, b) a mutation of the amino acid aspartic acid (D) on position 489, or c) a mutation of the amino acid serine (S) on position 398 and/or the amino acid lysine (K) on position 394. Compositions including an isolated nucleic acid molecule encoding the stable RSV F polypeptides are also described.
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公开(公告)号：US10457708B2
公开(公告)日：2019-10-29
申请号：US15742265
申请日：2016-07-07
IPC分类号： C07K14/005 , A61K39/12 , A61P31/14
摘要： Stable pre-fusion respiratory syncitial virus (RSV) F polypeptides, immunogenic compositions including the polypeptides, and uses thereof for the prevention and/or treatment of RSV infection are described.
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