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公开(公告)号：US11572380B2
公开(公告)日：2023-02-07
申请号：US16718702
申请日：2019-12-18
发明人： Norihisa Hamaguchi , Hitoshi Takaguchi , Yoshinori Fujimoto , Yutaka Kimoto , Hirokazu Hirai , Masayasu Takada
IPC分类号： C07H3/00 , A23L2/60 , A23L2/52 , A23L2/56 , C07H1/00 , C12C5/02 , A23C9/13 , A23G3/42 , A23G9/34 , A23C13/12 , A23G4/10 , A23C9/154 , A21D2/18 , A23L33/21 , A23L15/00 , A23L33/10 , A23L33/25 , C12C11/00
摘要： An object of the present invention is to provide a method for producing a saccharide polycondensate which is inexpensive and is applicable to a food or beverage product. Disclosed is a method for producing a saccharide polycondensate, which comprises carrying out a saccharide polycondensation reaction in the presence of activated carbon.
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公开(公告)号：US11498939B2
公开(公告)日：2022-11-15
申请号：US16332169
申请日：2017-09-14
申请人： ROQUETTE FRERES
发明人： Denis Simon , Olaf Haeusler , Solène Bock
IPC分类号： A61K31/718 , C08B33/00 , C07H3/00 , A61K31/70 , C07H1/00 , A23L29/30 , A23L29/20 , A23L33/125 , C08B31/00 , A23L33/10 , C08L3/12 , A23L13/40
摘要： The invention relates to a novel glucose polymer which is particularly useful for administration by the parenteral route, and to the method for the production thereof. The invention also relates to compositions comprising such a glucose polymer, and to the methods for the production thereof. The invention further relates to the use thereof as a medicament, for example as an osmotic agent for peritoneal dialysis.
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公开(公告)号：US20210310088A1
公开(公告)日：2021-10-07
申请号：US17100672
申请日：2020-11-20
申请人： Virdia, LLC
发明人： Robert JANSEN , Aharon EYAL
IPC分类号： C13K13/00 , C07H3/00 , C12P7/10 , C12P7/14 , C13K1/02 , A23K20/163 , A23K50/10 , C07H1/00 , C13K1/00
摘要： A method including: (a) selectively reacting a first sugar in a mixture which includes at least one second sugar to form a product mixture comprising a product of said first sugar; (b) separating said product of said first sugar from said product mixture; and (c) separating at least one of said at least one second sugar from said product mixture.
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公开(公告)号：US10550064B2
公开(公告)日：2020-02-04
申请号：US15769568
申请日：2016-11-01
IPC分类号： C07C51/47 , B01D15/36 , C07H3/00 , B01D15/34 , C07H3/02 , B01J20/26 , B01J20/28 , C07C59/265 , C07C55/10 , C07C59/08
摘要： A process of separating carboxylic acids comprising two steps. The first step is to provide an aqueous solution comprising (i) one or more mono-carboxylic acids, (ii) one or more di-carboxylic acids, and (iii) one or more tri-carboxylic acids. The second step is to pass the aqueous solution through a collection of resin particles, where the resin particles comprise covalently bound quaternary ammonium groups, and wherein the collection of resin particles has uniformity coefficient of 1.5 or less.
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公开(公告)号：US20200000911A1
公开(公告)日：2020-01-02
申请号：US16268287
申请日：2019-02-05
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/00 , A61K39/095 , C07H3/00 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
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公开(公告)号：US20190300558A1
公开(公告)日：2019-10-03
申请号：US16332169
申请日：2017-09-14
申请人： ROQUETTE FRERES
发明人： Denis SIMON , Olaf HAEUSLER
摘要： The invention relates to a novel glucose polymer which is particularly useful for administration by the parenteral route, and to the method for the production thereof. The invention also relates to compositions comprising such a glucose polymer, and to the methods for the production thereof. The invention further relates to the use thereof as a medicament, for example as an osmotic agent for peritoneal dialysis.
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公开(公告)号：US20190298822A1
公开(公告)日：2019-10-03
申请号：US16179476
申请日：2018-11-02
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , C12N7/00 , A61K39/00 , A61K39/095 , A61K39/102 , A61K39/145 , C07H3/00 , A61K39/116
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US10130653B2
公开(公告)日：2018-11-20
申请号：US15098096
申请日：2016-04-13
发明人： Youn-Mook Lim , Sung In Jeong , Hui-Jeong Gwon , Jong Seok Park , Jung-Bo Huh
摘要： An absorbable periodontal tissue and bone regeneration material uses bacterial cellulose that has been exposed to radiation. The bacterial cellulose was confirmed to block the invasion of soft tissue in a calvarial defect in rat and rabbit models and to display excellent absorptiveness enough to contribute bone formation. Therefore, the bacterial cellulose can be developed as an absorbable periodontal tissue and bone regeneration material useful in the field of medical engineering by regulating biodegradability without using chemicals that are toxic to human and environment.
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公开(公告)号：US09358279B2
公开(公告)日：2016-06-07
申请号：US14525883
申请日：2014-10-28
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/102 , A61K39/095 , A61K39/116 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/00 , A61K39/12
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising a Hib saccharide conjugate, at least one additional bacterial, for example N. meningitidis, saccharide conjugate(s), and a further antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 μg.
摘要翻译： 本申请公开了一种免疫原性组合物，其包含Hib糖结合物，至少一种额外的细菌，例如脑膜炎奈瑟球菌，糖结合物和选自全细胞百日咳和乙型肝炎表面抗原的另外的抗原， 其中Hib糖共轭物的糖剂量小于5μg。
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公开(公告)号：US09233151B2
公开(公告)日：2016-01-12
申请号：US13439829
申请日：2012-04-04
IPC分类号： A61K39/095 , A61K39/116 , A61K39/02 , A61K47/48 , A61K39/29 , A61K39/102 , A61K39/08 , A61K39/05 , C07H3/00 , A61K39/385 , A61K39/00
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminum adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
摘要翻译： 描述了一种多价疫苗组合物，其包含未吸附到铝佐剂盐上的流感嗜血杆菌b的荚膜多糖的缀合物和两种或更多种其它细菌多糖。 还描述了一种多价疫苗组合物，其包括全细胞百日咳组分，破伤风类毒素，白喉类毒素，乙型肝炎表面抗原，流感嗜血杆菌b的荚膜多糖的缀合物和荚膜多糖的缀合物。 A型或C型脑膜炎（或两者）。 此外，描述了包含全细胞百日咳组分，破伤风类毒素，白喉类毒素和低剂量流感嗜血杆菌b的荚膜多糖的缀合物的多价疫苗组合物。
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