公开(公告)号：US12076408B2

公开(公告)日：2024-09-03

申请号：US18220708

申请日：2023-07-11

申请人： Avilar Therapeutics, Inc.

发明人： Mark George Saulnier ,  Jesse Jingyang Chen ,  Srinivasa Karra ,  Kevin Tyler Sprott ,  Jason Allan Wiles ,  Soumya Ray

IPC分类号： C07H9/04 ,  A61K47/54 ,  A61K47/62 ,  C07H5/06 ,  C07H7/02 ,  C07H9/02 ,  C07H15/203 ,  C07H17/00 ,  C07H17/02 ,  C07H19/02 ,  C07H19/044 ,  H03L7/081 ,  H03L7/099

CPC分类号： A61K47/549 ,  A61K47/62 ,  C07H5/06 ,  C07H7/02 ,  C07H9/02 ,  C07H9/04 ,  C07H15/203 ,  C07H17/00 ,  C07H17/02 ,  C07H19/02 ,  C07H19/044 ,  H03L7/0814 ,  H03L7/0818 ,  H03L7/0998

摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

公开(公告)号：US20240270779A1

公开(公告)日：2024-08-15

申请号：US18564331

申请日：2022-03-14

申请人： NABOCUL COSMETICS CO., LTD.

发明人： Karl Wah-Keung TSIM ,  Takako SAKAI ,  Tina Ting-Xia DONG ,  Zhi-Tian PENG ,  Huai-You WANG ,  James WEI

IPC分类号： C07H15/203 ,  A61K8/02 ,  A61K8/60 ,  A61Q19/02 ,  A61Q19/08

CPC分类号： C07H15/203 ,  A61K8/0204 ,  A61K8/602 ,  A61Q19/02 ,  A61Q19/08

摘要： Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

公开(公告)号：US12024536B2

公开(公告)日：2024-07-02

申请号：US17863135

申请日：2022-07-12

申请人： UNIVERSITY OF KANSAS

发明人： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC分类号： C07H15/207 ,  C07C211/17 ,  C07H15/203

CPC分类号： C07H15/207 ,  C07C211/17 ,  C07H15/203

摘要： Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US11926640B2

公开(公告)日：2024-03-12

申请号：US17207388

申请日：2021-03-19

申请人： THE JOHNS HOPKINS UNIVERSITY ,  Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.

发明人： Barbara Slusher ,  Rana Rais ,  Lukas Tenora ,  Pavel Majer ,  Andrej Jancarik

IPC分类号： A61K31/404 ,  A61P35/00 ,  C07C227/14 ,  C07C245/18 ,  C07C271/22 ,  C07D209/18 ,  C07D209/20 ,  C07D211/90 ,  C07D263/04 ,  C07D263/18 ,  C07D309/10 ,  C07D317/38 ,  C07D317/40 ,  C07D473/34 ,  C07F9/24 ,  C07F9/6561 ,  C07H15/203 ,  C07H19/207 ,  C07K5/062 ,  C07K5/078 ,  C07K5/083 ,  A61K38/00

CPC分类号： C07F9/2458 ,  A61K31/404 ,  A61P35/00 ,  C07C227/14 ,  C07C245/18 ,  C07C271/22 ,  C07D209/18 ,  C07D209/20 ,  C07D211/90 ,  C07D263/04 ,  C07D263/18 ,  C07D309/10 ,  C07D317/38 ,  C07D317/40 ,  C07D473/34 ,  C07F9/65616 ,  C07H15/203 ,  C07H19/207 ,  C07K5/06026 ,  C07K5/06156 ,  C07K5/0808 ,  A61K38/00

摘要： The disclosure provides compounds having formula (I):




and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.

公开(公告)号：US11891655B2

公开(公告)日：2024-02-06

申请号：US17730004

申请日：2022-04-26

申请人： Battelle Memorial Institute

发明人： Aaron T. Wright ,  Susan Ramos-Hunter ,  Christopher Whidbey

IPC分类号： C12Q1/68 ,  C12Q1/6837 ,  C07K1/13 ,  C12Q1/6841 ,  C12Q1/48 ,  C07D311/16 ,  C07D405/04 ,  C07C233/33 ,  C07C233/20 ,  C07C247/00 ,  G01N33/58 ,  C07C305/22 ,  C07D203/26 ,  C07C247/12 ,  C07C203/04 ,  C07C271/28 ,  C07D405/12 ,  C07H19/067 ,  C07H15/203 ,  C12Q1/34 ,  C07C317/40

CPC分类号： C12Q1/6837 ,  C07C203/04 ,  C07C233/20 ,  C07C233/33 ,  C07C247/00 ,  C07C247/12 ,  C07C271/28 ,  C07C305/22 ,  C07C317/40 ,  C07D203/26 ,  C07D311/16 ,  C07D405/04 ,  C07D405/12 ,  C07H15/203 ,  C07H19/067 ,  C07K1/13 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/6841 ,  G01N33/582 ,  G01N33/583 ,  C12Q2565/514 ,  C12Q2600/106 ,  G01N2333/91177

摘要： Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.

公开(公告)号：US20240018174A1

公开(公告)日：2024-01-18

申请号：US18232909

申请日：2023-08-11

申请人： Ventana Medical Systems, Inc.

发明人： Christopher Bieniarz ,  Julia Ashworth-Sharpe ,  Brian D. Kelly ,  Nathan Polaske

IPC分类号： C07F9/6561 ,  C07F9/6518 ,  C07F9/6558 ,  C07F9/12 ,  C07D209/14 ,  C07H15/203 ,  C07H15/26 ,  C07F9/58 ,  C07F9/6503 ,  C12Q1/42 ,  C07H15/207 ,  G01N33/58 ,  C07D403/06 ,  C07F9/6533 ,  C07H17/02 ,  C07F9/06

CPC分类号： C07F9/6561 ,  C07F9/6518 ,  C07F9/65583 ,  C07F9/12 ,  C07D209/14 ,  C07H15/203 ,  C07H15/26 ,  C07F9/58 ,  C07F9/65031 ,  C12Q1/42 ,  C07H15/207 ,  G01N33/581 ,  C07D403/06 ,  C07F9/65335 ,  C07H17/02 ,  C07F9/06

摘要： Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

公开(公告)号：US11786586B2

公开(公告)日：2023-10-17

申请号：US16471738

申请日：2017-12-22

申请人： AOA Dx

发明人： Horacio Uri Saragovi

IPC分类号： A61K39/00 ,  A61K39/385 ,  C07K16/30 ,  A61P35/04 ,  C07H15/203 ,  A61P37/04 ,  A61P35/00 ,  C40B40/02 ,  A61P31/20 ,  A61P31/14 ,  C40B30/04 ,  A61P31/04 ,  A61P31/18

CPC分类号： A61K39/001171 ,  A61K39/385 ,  A61P31/04 ,  A61P31/14 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  A61P37/04 ,  C07H15/203 ,  C07K16/3084 ,  C40B30/04 ,  C40B40/02 ,  A61K2039/6081 ,  A61K2039/6093 ,  A61K2039/627

摘要： The present invention provides methods and compositions related to multivalent carbohydrate antigen structures comprising cancer or infection associated ganglioside carbohydrate antigens. Said carbohydrate structures may be used to induce immunity against said carbohydrate antigens. In some embodiments, carbohydrate structures may be administered to a subject thereby inducing immunity in the subject, for example, the administration of a vaccine comprising said carbohydrate structure. Also provided are methods to induce an immune response in a subject in need thereof by administering said carbohydrate structure. Further provided are methods of producing an antibody or TCR that bind said carbohydrate antigens.

公开(公告)号：US20230114811A1

公开(公告)日：2023-04-13

申请号：US17904632

申请日：2021-02-19

申请人： THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED

发明人： Yule WANG ,  Ross Graham ATKINSON ,  Yar-Khing YAUK ,  Pengmin LI

IPC分类号： C12N15/82 ,  C12P19/56 ,  C12N9/10 ,  C07H15/203

摘要： The invention provides a method of producing a host cell, plant cell or plant with increased trilobatin content or increased N 4′-O-glycosyltransferase activity, the method comprising transformation of the host cell or plant cell with a polynucleotide encoding a polypeptide with 4′-O-glycosyltransferase activity. The invention also provides host cells, plant cells and plants, genetically modified to contain and or express the polynucleotides.

公开(公告)号：US20230102047A1

公开(公告)日：2023-03-30

申请号：US17863135

申请日：2022-07-12

申请人： UNIVERSITY OF KANSAS

发明人： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC分类号： C07H15/207 ,  C07H15/203 ,  C07C211/17

摘要： Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20230033327A1

公开(公告)日：2023-02-02

申请号：US17896154

申请日：2022-08-26

申请人： Washington University

发明人： James W. JANETKA ,  Zhenfu HAN ,  Scott HULTGREN ,  Jerry PINKER ,  CORINNE CUSUMANO

IPC分类号： C07H15/203 ,  C07H15/26 ,  A61K31/7034 ,  A61K31/7042 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K45/06

摘要： The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.