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公开(公告)号：US20240307546A1
公开(公告)日：2024-09-19
申请号：US18653655
申请日：2024-05-02
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/081 , H03L7/099
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/0814 , H03L7/0818 , H03L7/0998
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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公开(公告)号：US12091402B2
公开(公告)日：2024-09-17
申请号：US18220737
申请日：2023-07-11
发明人： Jason Allan Wiles , Srinivasa Karra , Mark George Saulnier , Jesse Jingyang Chen , Kevin Tyler Sprott , Soumya Ray
IPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
CPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
摘要： Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.
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公开(公告)号：US12076408B2
公开(公告)日：2024-09-03
申请号：US18220708
申请日：2023-07-11
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： C07H9/04 , A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/081 , H03L7/099
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/0814 , H03L7/0818 , H03L7/0998
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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4.发明公开公开(公告)号：US20240279209A1
公开(公告)日：2024-08-22
申请号：US18590713
申请日：2024-02-28
发明人： Jason Allan Wiles , Srinivasa Karra , Mark George Saulnier , Jesse Jingyang Chen , Kevin Tyler Sprott , Soumya Ray
IPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
CPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
摘要： Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.
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公开(公告)号：US20240245785A1
公开(公告)日：2024-07-25
申请号：US18584914
申请日：2024-02-22
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/081 , H03L7/099
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/0814 , H03L7/0818 , H03L7/0998
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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6.发明公开公开(公告)号：US20240239828A1
公开(公告)日：2024-07-18
申请号：US18586086
申请日：2024-02-23
发明人： Jason Allan Wiles , Srinivasa Karra , Daniel Grau , Soumya Ray
摘要： Compounds and compositions that have a mannose 6-phosphate receptor or ASGPR binding ligand bound to an extracellular protein binding ligand are provided for the selective degradation of a target extracellular protein in vivo to treat disorders mediated by the extracellular protein.
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公开(公告)号：US11819551B2
公开(公告)日：2023-11-21
申请号：US17877538
申请日：2022-07-29
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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公开(公告)号：US20230097256A1
公开(公告)日：2023-03-30
申请号：US17877538
申请日：2022-07-29
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H17/00 , C07H17/02 , C07H15/203 , C07H7/02 , C07H9/02 , C07H19/044 , C07H19/02
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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公开(公告)号：US12128106B2
公开(公告)日：2024-10-29
申请号：US18584914
申请日：2024-02-22
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/081 , H03L7/099
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/0814 , H03L7/0818 , H03L7/0998
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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10.发明公开公开(公告)号：US20240101539A1
公开(公告)日：2024-03-28
申请号：US18220737
申请日：2023-07-11
发明人： Jason Allan Wiles , Srinivasa Karra , Mark George Saulnier , Jesse Jingyang Chen , Kevin Tyler Sprott , Soumya Ray
IPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
CPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07H17/00 , C07H17/02
摘要： Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.
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