- 专利标题： ASGPR-binding compounds for the degradation of extracellular proteins
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申请号： US17877538申请日： 2022-07-29
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公开(公告)号： US11819551B2公开(公告)日： 2023-11-21
- 发明人: Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
- 申请人： Avilar Therapeutics, Inc.
- 申请人地址： US MA Waltham
- 专利权人： Avilar Therapeutics, Inc.
- 当前专利权人： Avilar Therapeutics, Inc.
- 当前专利权人地址： US MA Waltham
- 代理机构： Knowles Intellectual Property Strategies, LLC
- 主分类号： A61K47/54
- IPC分类号： A61K47/54 ; A61K47/62 ; C07H5/06 ; C07H7/02 ; C07H9/02 ; C07H15/203 ; C07H17/00 ; C07H17/02 ; C07H19/02 ; C07H19/044
摘要：
Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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