- 专利标题： POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS
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申请号： US18590713申请日： 2024-02-28
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公开(公告)号： US20240279209A1公开(公告)日： 2024-08-22
- 发明人: Jason Allan Wiles , Srinivasa Karra , Mark George Saulnier , Jesse Jingyang Chen , Kevin Tyler Sprott , Soumya Ray
- 申请人： Avilar Therapeutics, Inc.
- 申请人地址： US MA Waltham
- 专利权人： Avilar Therapeutics, Inc.
- 当前专利权人： Avilar Therapeutics, Inc.
- 当前专利权人地址： US MA Waltham
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D405/14 ; C07D417/12 ; C07H17/00 ; C07H17/02
摘要：
Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.
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