USE OF INHIBITOR OF BETA-LACTAMASES AND ITS COMBINATION WITH BETA-LACTAM ANTIBIOTICS
    3.
    发明申请
    USE OF INHIBITOR OF BETA-LACTAMASES AND ITS COMBINATION WITH BETA-LACTAM ANTIBIOTICS 审中-公开
    β-LACTAMASES抑制剂的使用及其与BETA-LACTAM抗生素的组合

    公开(公告)号:US20110172200A1

    公开(公告)日:2011-07-14

    申请号:US12864671

    申请日:2009-01-28

    CPC分类号: C07D477/00 A61K31/397

    摘要: The present invention relates to a pharmaceutical composition with broad-spectrum of activity against class A, class C and D enzymes comprising an antibiotic and a pharmaceutically effective amount of a compound of Formula (I), compounds of Formula (I), the use of a therapeutically effective amount of one or more compounds of Formula (I) as a broad-spectrum beta-lactamase inhibitor and the use of such a pharmaceutical composition for the treatment of an infection in humans or animals caused by bacteria.

    摘要翻译: 本发明涉及具有针对A类,C类和D类的广谱活性的药物组合物,其包含抗生素和药学有效量的式(I)化合物,式(I)化合物,使用 治疗有效量的一种或多种式(I)化合物作为广谱β-内酰胺酶抑制剂,以及这种药物组合物用于治疗由细菌引起的人或动物感染的用途。

    Process for Producing Carbapenem Derivative and Intermediate Crystal Therefor
    6.
    发明申请
    Process for Producing Carbapenem Derivative and Intermediate Crystal Therefor 有权
    生产碳氢化合物衍生物和中间体晶体的方法

    公开(公告)号:US20080171864A1

    公开(公告)日:2008-07-17

    申请号:US11884195

    申请日:2006-02-14

    IPC分类号: C07D477/12

    摘要: An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).

    摘要翻译: 本发明的目的是提供一种在工业过程中有利的碳青霉烯合成中间体。 提供了一种制备化合物(I)或其药学上可接受的盐或其溶剂化物或其结晶的方法,其包括在仲胺存在下使化合物(III)和化合物(IV)与苄醇化的 化合物(I)的晶体。 还提供了使用Pd催化剂和化合物(IV)的结晶使化合物(I)脱保护的方法。