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    Carbapenem derivatives
    4.
    发明授权
    Carbapenem derivatives 失效
    卡巴培南衍生物

    公开(公告)号：US06908913B2

    公开(公告)日：2005-06-21

    申请号：US10344729

    申请日：2001-11-22

    申请人： Yuko Kano ,  Yasuo Yamamoto ,  Takahisa Maruyama ,  Takehiko Sawabe ,  Eiki Shitara ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Takashi Ida

    发明人： Yuko Kano ,  Yasuo Yamamoto ,  Takahisa Maruyama ,  Takehiko Sawabe ,  Eiki Shitara ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Takashi Ida

    IPC分类号： A61P31/04 ,  C07D477/14 ,  C07D519/00 ,  A61K31/429 ,  C07D519/06

    CPC分类号： C07D477/14

    摘要： An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl, R2 and R3 each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

    摘要翻译： 本发明的目的是提供对MRSA，PRSP，流感病毒和产生β-内酰胺酶的细菌具有强抗生素活性并且对DHP-1稳定的碳青霉烯衍生物。 根据本发明的碳青霉烯衍生物是由式（I）和（II）表示的化合物或其药学上可接受的盐：其中R 1表示H或甲基，R 2， 和R 3各自独立地表示H; 卤素; 取代或未取代的烷基; 环烷基 取代或未取代的烷基羰基; 氨基甲酰基; 取代或未取代的芳基; 取代或未取代的烷硫基; 吗啉基 烷基磺酰基; 或甲酰基，n为0（零）至4，Hy表示取代或未取代的单环或双环杂环基。

    Novel carbapenem derivatives
    5.
    发明申请
    Novel carbapenem derivatives 失效
    新型碳青霉烯衍生物

    公开(公告)号：US20030149016A1

    公开(公告)日：2003-08-07

    申请号：US10217670

    申请日：2002-08-14

    发明人： Yuko Kano ,  Toshiro Sasaki ,  Yumiko Sambongi ,  Kiyoshi Tanabe ,  Yoshihisa Akiyama ,  Hideo Kitagawa ,  Takahisa Maruyama ,  Hiromasa Takizawa ,  Takashi Ando ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Takashi Ida

    IPC分类号： A61K031/407 ,  C07D487/08

    CPC分类号： C07D477/14

    摘要： Disclosed is a novel carbapenem derivative having a substituted imidazonull5,1-bnullthiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against null-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof: 1

    摘要翻译： 公开了一种在碳青霉烯环的2-位上具有取代的咪唑并[5,1-b]噻唑基的新型碳青霉烯衍生物对β-内酰胺酶生产细菌，MRSA，耐药铜绿假单胞菌PRSP具有高抗微生物活性 ，肠球菌和流感，以及DHP-1的高度稳定性。 根据本发明，提供由式（I）表示的化合物或其药理学上可接受的盐或其碳青霉烯环的3-位上的酯：

    Adhesive composition
    8.
    发明授权
    Adhesive composition 失效
    粘合剂组合物

    公开(公告)号：US5480720A

    公开(公告)日：1996-01-02

    申请号：US204929

    申请日：1994-03-01

    申请人： Eric K. Eisenhart ,  Louis C. Graziano ,  Jose P. Lalas

    发明人： Eric K. Eisenhart ,  Louis C. Graziano ,  Jose P. Lalas

    IPC分类号： C07C307/04 ,  C07D207/26 ,  C07D207/273 ,  C07D477/02 ,  C07D477/14 ,  C07D477/20 ,  C07D501/00 ,  C08L63/00 ,  C09J133/06 ,  B32B27/38

    CPC分类号： C07D207/273 ,  C07C307/04 ,  C07D477/02 ,  C07D477/14 ,  C07D477/20 ,  C07D501/00 ,  C09J133/064 ,  C08L63/00 ,  Y10T428/31515 ,  Y10T428/31895 ,  Y10T428/31928

    摘要： An adhesive composition includes from about 30 weight percent to about 70 weight percent solids dispersed in an aqueous medium. The solids include from about 60 weight percent to about 97.9 weight percent of a polymer having a glass transition temperature of about -40.degree. C. to about 10.degree. C. and including first repeating units derived from an alkyl (meth)acrylate monomer, a vinyl ester monomer, a styrenic monomer or a mixture thereof and second repeating units derived from a hydroxyalkyl (meth)acrylate monomer, a monoethylenically unsaturated nitrogenous monomer or a mixture thereof; from about 2 weight percent to about 30 weight percent of a polyfunctional epoxy resin including two or more epoxide groups per molecule; from about 0.1 weight percent to about 10 weight percent of a polyfunctional curing agent including two or more amino groups or amido groups per molecule; and from about 0.01 weight percent to about 30 weight percent of a metal salt. A method for making a laminate includes applying a layer of the aqueous adhesive composition to a first substrate layer and covering the layer of adhesive composition with a second substrate layer to form the laminated article. A laminate includes two substrate layers bonded together by an interposed layer of the solids of the adhesive composition.

    摘要翻译： 粘合剂组合物包含分散在水性介质中的约30重量％至约70重量％的固体。 固体包括约60重量％至约97.9重量％的玻璃化转变温度为约-40℃至约10℃的聚合物，并且包括衍生自（甲基）丙烯酸烷基酯单体的第一重复单元， 乙烯基酯单体，苯乙烯单体或其混合物，以及衍生自（甲基）丙烯酸羟烷基酯单体，单烯属不饱和含氮单体或其混合物的第二重复单元; 约2重量％至约30重量％的每分子包含两个或更多个环氧基团的多官能环氧树脂; 约0.1重量％至约10重量％的每分子含有两个或多个氨基或酰氨基的多官能固化剂; 和约0.01重量％至约30重量％的金属盐。 制造层压体的方法包括将水性粘合剂组合物层施加到第一基材层并用第二基材层覆盖粘合剂组合物层以形成层压制品。 层压体包括通过粘合剂组合物的固体的插入层粘合在一起的两个基底层。