-
1.发明申请D-homoandrosta-17-yl carbamate derivatives as selective glucocorticoid receptor ligands 失效D-雄甾烷基-17-氨基甲酸酯衍生物作为选择性糖皮质激素受体配体公开(公告)号：US20090306202A1
公开(公告)日：2009-12-10
申请号：US11919195
申请日：2006-05-15
IPC分类号： A61K31/27 , C07C261/00
CPC分类号： C07J63/008
摘要： The present invention is directed to D-homoandrosta-17-yl-carbamate derivatives as selective glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明涉及作为用于治疗各种自身免疫性和炎性疾病或病症的选择性糖皮质激素受体配体的D-雄性雄激素-17-氨基甲酸酯衍生物。 还包括药物组合物和使用方法。
-
公开(公告)号：US20090163559A1
公开(公告)日：2009-06-25
申请号：US12378198
申请日：2009-02-12
IPC分类号： A61K31/4192
CPC分类号： A61K31/4192
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.
-
公开(公告)号：US5356889A
公开(公告)日：1994-10-18
申请号：US966969
申请日：1992-10-26
IPC分类号： A61K31/40 , A61K31/397 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61P31/04 , C07D477/00 , C07D477/14 , C07D521/00 , A01N43/00 , A61K31/395 , C07D487/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D477/14
摘要： Disclosed are carbapenems of the formula ##STR1## which are 2-(9-fluorenonyl)-carbapenems useful as antibacterial agents. Intermediates for preparation of these compounds is also disclosed.
摘要翻译： 公开的是具有用作抗菌剂的2-（9-芴基） - 碳青霉烯类的式“IMAGE”的碳青霉烯。 还公开了用于制备这些化合物的中间体。
-
公开(公告)号：US5214139A
公开(公告)日：1993-05-25
申请号：US686109
申请日：1991-04-16
申请人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
发明人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
IPC分类号： C07D477/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D477/14 , Y02P20/55
摘要： Carbapenems of the formula ##STR1## wherein: P' is a removable protecting group for hydroxy; andM is a removable protecting group for carboxy;are useful intermediates for carbapenem antibiotics.
摘要翻译： 式中：P'是羟基的可除去的保护基; M为羧基的可除去保护基; 是碳青霉烯类抗生素的有用中间体。
-
公开(公告)号：US5182384A
公开(公告)日：1993-01-26
申请号：US705238
申请日：1991-05-24
申请人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
发明人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
摘要翻译： 公式为“IMAGE”
的碳青霉烯类是抗菌剂的有用中间体。 -
公开(公告)号：US5034384A
公开(公告)日：1991-07-23
申请号：US561547
申请日：1990-08-01
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## wherein either the 2-fluoren-9-one or 3-fluoren-9-one is attached at the 2-position of the carbapenem are useful antibacterial agents.
摘要翻译： 其中2-碳烯-9-酮或3-芴-9-酮在碳青霉烯类的2-位上连接的式“IMAGE”的碳青霉烯类是有用的抗菌剂。
-
公开(公告)号：US5006519A
公开(公告)日：1991-04-09
申请号：US551707
申请日：1990-07-11
申请人： Frank P. DiNinno , Mark L. Greenlee
发明人： Frank P. DiNinno , Mark L. Greenlee
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful antibacterial agents.
摘要翻译： 配方
的碳青霉烯类是有用的抗菌剂。 -
公开(公告)号：US08722727B2
公开(公告)日：2014-05-13
申请号：US13058227
申请日：2009-08-10
申请人： Mark L. Greenlee , Robert Wilkening , James Apgar , Donald Sperbeck , Kenneth J. Wildonger , Dongfang Meng , Dann L. Parker, Jr. , Ahmed Mamai
发明人： Mark L. Greenlee , Robert Wilkening , James Apgar , Donald Sperbeck , Kenneth J. Wildonger , Dongfang Meng , Dann L. Parker, Jr. , Ahmed Mamai
IPC分类号： A61K31/35 , C07D311/78
CPC分类号： A61K31/21 , A61K31/41 , C07D405/04
摘要： Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
摘要翻译： 本文公开了enfumafungin的新型衍生物以及“其药学上可接受的盐，水合物和前药”。 还公开了包含这种化合物的组合物，制备这些化合物的方法和使用这些化合物作为抗真菌剂和/或（1,3） - ＆bgr-D-葡聚糖合酶抑制剂的方法。 所公开的化合物，其药学上可接受的盐，水合物和前药，以及包含这些化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。
-
9.发明授权17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators 失效17-氨甲酰氧基皮质醇衍生物作为选择性糖皮质激素受体调节剂公开(公告)号：US07732432B2
公开(公告)日：2010-06-08
申请号：US10540757
申请日：2004-01-16
CPC分类号： C07J41/005 , C07J43/00
摘要： The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括式（I）化合物或其药学上可接受的盐或水合物，其可用作治疗各种自身免疫性和炎性疾病或病症的选择性糖皮质激素受体配体。 还包括药物组合物和使用方法。
-
公开(公告)号：US5153186A
公开(公告)日：1992-10-06
申请号：US705239
申请日：1991-05-24
申请人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
发明人： Frank DiNinno , Thomas A. Rano , Mark L. Greenlee
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful antibacterial agents.
摘要翻译： 公式
的碳青霉烯类是有用的抗菌剂。
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.03 秒)
