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21 条记录 (耗时 0.019 秒)

    Process of producing 8A- and 9A-azalide antibiotics
    4.
    发明授权
    Process of producing 8A- and 9A-azalide antibiotics 失效
    生产8A-和9A-氮杂抗生素的方法

    公开(公告)号：US5332807A

    公开(公告)日：1994-07-26

    申请号：US48048

    申请日：1993-04-14

    申请人： Sherman T. Waddell ,  Timothy A. Blizzard

    发明人： Sherman T. Waddell ,  Timothy A. Blizzard

    IPC分类号： C07H17/00 ,  C07H17/02 ,  C07D273/01 ,  C07H17/08

    CPC分类号： C07H17/02 ,  C07H17/00

    摘要： A process of producing 8a- and 9a- azalide compounds is disclosed, comprised of reacting an 8a- aza or 9a- aza azalide eastern fragment or a derivative thereof with a compound of the formula:X--A'--Ywherein X and Y are appropriate reactive groups and A' is a fragment or compound which forms the western portion of the azalide, andcyclizing this intermediate to form the target 8a- or 9a-azalide compound. Compounds of formula I, II and III as well as other azalides can be synthesized according to this process.

    摘要翻译： 公开了一种制备8α和9α-氮杂化合物的方法，其包括使8-氮杂或9-氮杂氮杂东片段或其衍生物与下式化合物：X-A'-Y反应，其中X和Y为 合适的反应性基团和A'是形成氮杂环化合物的西部的片段或化合物，并使该中间体环化以形成目标8a-或9a-氮杂化合物。 式I，II和III的化合物以及其它的氮杂化物可以根据该方法合成。

    Synthetic marcfortine derivatives useful as antiparasitic agents
    10.
    发明授权
    Synthetic marcfortine derivatives useful as antiparasitic agents 失效
    用作抗寄生虫剂的合成马可氟汀衍生物

    公开(公告)号：US4923867A

    公开(公告)日：1990-05-08

    申请号：US235418

    申请日：1988-08-24

    申请人： Timothy A. Blizzard ,  Helmut Mrozik

    发明人： Timothy A. Blizzard ,  Helmut Mrozik

    IPC分类号： A01N43/90 ,  C07D491/22

    CPC分类号： C07D491/22 ,  A01N43/90

    摘要： There are disclosed synthetic marcfortine derivatives of the natural products marcfortine A, marcfortine B, and marcfortine C. The synthetic derivatives are described in the following formula: ##STR1## wherein: n is 0 or 1R.sub.1 is hydrogen, loweralkyl, benzyl, lower alkanoyl, benzenesulfonyl in which the benzene ring is substituted with from 0 to 3 substituents selected from lower alkyl groups, lower alkoxy groups and halogen atoms, lower alkylamino-carbonyl, lower alkoxy-carbonyl;R.sub.24 is hydrogen, halogen or lower alkoxy (provided that R.sub.24 is other than hydrogen only if the broken line represents a single bond at the 24, 25-position),R.sub.25 is hydrogen or halogen (provided that R.sub.25 is other than hydrogen only if the broken line represents a single bond at the 24, 25-position);R.sub.29 is hydrogen, lower alkyl, alkoxyalkyl, haloalkyl, lower alkenyl, lower alkynyl, benzyl, lower alkanoyl, substituted benzenesulfonyl, lower alkylamino-carbonyl, not hydrogen or methyl if R.sub.1 is hydrogen; and the broken line represents a single or double bond between carbons 24 and 25.The compounds are active antiparasitic agents useful in particular against insect and nematode pests, and compositions for that use are disclosed.

    摘要翻译： 公开了天然产物马可氟汀A，马可氟汀B和马可氟汀C的合成马可氟汀衍生物。合成衍生物描述于下式中：其中：n为0或1，R1为氢，低级烷基，苄基，低级烷酰基 苯磺酰基，其中苯环被0-3个选自低级烷基，低级烷氧基和卤素原子的取代基取代，低级烷基氨基 - 羰基，低级烷氧羰基; R24是氢，卤素或低级烷氧基（只要虚线表示24,25位的单键，R24不是氢），R25是氢或卤素（只要R25不是氢，只要是 虚线代表24,25位的单键）; 如果R1是氢，R29是氢，低级烷基，烷氧基烷基，卤代烷基，低级烯基，低级炔基，苄基，低级烷酰基，取代的苯磺酰基，低级烷基氨基 - 羰基，不是氢或甲基; 并且虚线表示碳24和25之间的单键或双键。化合物是有效的抗寄生虫剂，特别适用于昆虫和线虫害虫，并且公开了该用途的组合物。