发明申请
- 专利标题： Process for Producing Carbapenem Derivative and Intermediate Crystal Therefor
- 专利标题（中）： 生产碳氢化合物衍生物和中间体晶体的方法
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申请号： US11884195申请日： 2006-02-14
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公开(公告)号： US20080171864A1公开(公告)日： 2008-07-17
- 发明人: Masaaki Uenaka , Yasuyuki Hozumi , Kouichi Noguchi , Tadafumi Komurasaki
- 申请人： Masaaki Uenaka , Yasuyuki Hozumi , Kouichi Noguchi , Tadafumi Komurasaki
- 优先权： JP2005-037088 20050215; JP2005-193257 20050701
- 国际申请： PCT/JP06/02482 WO 20060214
- 主分类号： C07D477/12
- IPC分类号： C07D477/12
摘要：
An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).
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