公开(公告)号：US20250059217A1

公开(公告)日：2025-02-20

申请号：US18562587

申请日：2022-05-25

Applicant: Bright Minds Biosciences Inc. ,  The Medical College of Wisconsin Inc.

Inventor： Alan Kozikowski ,  Werner Tueckmantel ,  John McCorvy ,  Uro Laban

IPC: C07F9/572 ,  A61K31/4045 ,  A61K31/5383 ,  A61K31/675 ,  C07D209/16 ,  C07D403/06 ,  C07D498/06

Abstract: This disclosure relates to heterocyclic compounds of Formula (I), Formula (II), and Formula (III) as well as the preparation and use thereof. As contemplated herein, heterocyclic compounds of Formula (I), Formula (II), and Formula (III) may be used for the treatment of neuropsychiatric, and neurodegenerative, neuroinflammatory and pain disorders including depression, as well as tobacco, opiate, and cocaine addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain syndromes including cluster headaches and chemotherapy induced peripheral neuropathy. Formula (I), Formula (II), Formula (III).

公开(公告)号：US20250051313A1

公开(公告)日：2025-02-13

申请号：US18722747

申请日：2022-12-22

Applicant: Sitryx Therapeutics Limited

Inventor： David COUSIN ,  Oscar BARBA

IPC: C07D403/14 ,  A61K31/502 ,  C07D403/06 ,  C07D405/14

Abstract: The invention relates to a compound of formula (I) which is 6-((1H-pyrazol-4-yl)sulfonyl)-2-((1-cyclopropyl-1H-pyrazol-3-yl)methyl)phthalazin-1(2H)-one; or a salt and/or solvate thereof; and to its use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder.

公开(公告)号：US12187687B2

公开(公告)日：2025-01-07

申请号：US16621585

申请日：2018-06-26

Applicant: University of Virginia Patent Foundation

Inventor： Ku-Lung Hsu ,  Caroline Elise Franks ,  Heung Sik Hahm ,  Jeffrey W. Brulet ,  Tao Huang

IPC: C07D241/04 ,  A61P35/00 ,  C07D211/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D471/08 ,  C07D513/04

Abstract: The disclosure is directed to compounds of the formula (1A), (I)—(V) and others disclosed herein and uses of such compounds.

公开(公告)号：US12187685B2

公开(公告)日：2025-01-07

申请号：US18370519

申请日：2023-09-20

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zachary Owyang ,  Robert Malmstrom

IPC: C07D237/34 ,  A61P35/00 ,  C07D239/34 ,  C07D403/06 ,  C07K14/00

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

公开(公告)号：US20250002464A1

公开(公告)日：2025-01-02

申请号：US18701800

申请日：2022-10-18

Applicant: SAPIENSBIO INC.

Inventor： Dong-Oh YOON ,  Kanghyun RYOO ,  Hyunseung LEE ,  Incheol RYU ,  Eun Jeong JEONG ,  Myoungwoo LEE ,  Jin Woo LEE ,  Je Hak KIM

IPC: C07D241/42 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D487/04

Abstract: The present invention relates to a novel compound that is effective in inhibiting fibrosis. The inventors confirmed that the compound has an effect of inhibiting actin polymerization and not only reduces the levels of all types of fibrosis biomarkers but also effectively inhibits the expression of α-SMA, which is a major causative factor of fibrosis. Therefore, the novel compound according to the present invention is expected to be effectively used as a preparation having an excellent effect of alleviating and inhibiting fibrosis to prevent and treat a fibrosis disease.

公开(公告)号：US20240383866A1

公开(公告)日：2024-11-21

申请号：US18783231

申请日：2024-07-24

Applicant: ASTRAZENECA AB

Inventor： KAROLINA NILSSON ,  MARTIN BAUER ,  MARIA OLWEGARD HALVARSSON ,  MIKAEL BRINK ,  JON PAUL JANET

IPC: C07D251/18 ,  C07D401/06 ,  C07D403/06 ,  C07D405/10 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04

Abstract: There are disclosed certain 2,4,6-trisubstituted 1,3,5-triazine compounds of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are modulators of CX3CR1 and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as non-ischemic dilated cardiomyopathy and heart failure.

公开(公告)号：US12139458B2

公开(公告)日：2024-11-12

申请号：US17309956

申请日：2020-01-07

Applicant: UNIWERSYTET JAGIELLONSKI ,  WARSZAWSKI UNIWERSYTET MEDYCZNY

Inventor： Krzysztof Kaminski ,  Michal Abram ,  Anna Rapacz ,  Szczepan Mogilski ,  Gniewomir Latacz ,  Bartlomiej Szulczyk

IPC: C07D403/06 ,  A61K31/496 ,  A61P25/04 ,  C07D207/40 ,  C07D207/416 ,  C07D401/06

Abstract: The first object of the invention is the compound of general formula (I) or pharmaceutically acceptable salts thereof. A second object of the invention is the use of compounds described by general formula (I) as active ingredient in pharmaceutical compositions for the treatment of epileptic seizures or neuropathic pain or migraine.

公开(公告)号：US20240368087A1

公开(公告)日：2024-11-07

申请号：US18433099

申请日：2024-02-05

Applicant: VANDERBILT UNIVERSITY ,  The UAB Research Foundation ,  The Trustees of the University of Pennsylvania ,  The Trustees of the University of Pennsylvania

Inventor： David J. MALONEY ,  Alex Gregory WATERSON ,  Ganesh Rai BANTUKALLU ,  Kyle Ryan BRIMACOMBE ,  Plamen CHRISTOV ,  Chi V. DANG ,  Victor DARLEY-USMAR ,  Xin HU ,  Ajit JADHAV ,  Somnath JANA ,  Kwangho KIM ,  Jennifer L. KOUZNETSOVA ,  William J. MOORE ,  Bryan T. MOTT ,  Leonard M. NECKERS ,  Anton SIMEONOV ,  Gary Allen SULIKOWSKI ,  Daniel Jason URBAN ,  Shyh Ming YANG

IPC: C07D231/20 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5355 ,  A61K45/06 ,  C07D231/38 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D495/14

Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

公开(公告)号：US20240360115A1

公开(公告)日：2024-10-31

申请号：US18764292

申请日：2024-07-04

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C07D413/06 ,  A61K31/341 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00

CPC classification number: C07D413/06 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  A61K31/341 ,  A61K2300/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20240336641A1

公开(公告)日：2024-10-10

申请号：US18747540

申请日：2024-06-19

Applicant: Mindset Pharma Inc.

Inventor： Abdelmalik Slassi ,  Joseph Araujo

IPC: C07F9/572 ,  A61K31/675 ,  C07D403/06

CPC classification number: C07F9/5728 ,  C07D403/06 ,  A61K31/675 ,  C07B2200/05

Abstract: The present application relates to 3-cyclic amine-indole derivatives of general Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses, and other neurological diseases, disorders and conditions.