公开(公告)号：US20240067612A1

公开(公告)日：2024-02-29

申请号：US18218149

申请日：2023-07-05

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zach Owyang ,  Robert Malmstrom

IPC: C07D239/34 ,  C07D403/06 ,  C07K14/00 ,  A61P35/00

CPC classification number: C07D239/34 ,  C07D403/06 ,  C07K14/001 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):






or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

公开(公告)号：US20240140915A1

公开(公告)日：2024-05-02

申请号：US18370519

申请日：2023-09-20

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zachary Owyang ,  Robert Malmstrom

IPC: C07D239/34 ,  A61P35/00 ,  C07D403/06 ,  C07K14/00

CPC classification number: C07D239/34 ,  A61P35/00 ,  C07D403/06 ,  C07K14/001

Abstract: Disclosed are compounds of Formula (I):




or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

公开(公告)号：US12187685B2

公开(公告)日：2025-01-07

申请号：US18370519

申请日：2023-09-20

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zachary Owyang ,  Robert Malmstrom

IPC: C07D237/34 ,  A61P35/00 ,  C07D239/34 ,  C07D403/06 ,  C07K14/00

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.