公开(公告)号：US20230312496A1

公开(公告)日：2023-10-05

申请号：US18022601

申请日：2021-08-23

Applicant: The Lubrizol Corporation ,  Ohio State Innovation Foundation

Inventor： Paul E. Adams ,  Shiyu Zhang ,  Christopher M. Rasik ,  Shelby Davis ,  Madison Tuttle ,  Ryan Richard Konrad

IPC: C07D285/12 ,  H01M8/18 ,  H01M8/0239

CPC classification number: C07D285/12 ,  H01M8/188 ,  H01M8/0239 ,  H01M2300/0002

Abstract: The disclosed technology relates to 2,5-dimercapto-1,3,4-thiadiazole metal salts and electrolytes therewith for use in redox flow batteries.

公开(公告)号：US20210127678A1

公开(公告)日：2021-05-06

申请号：US17041919

申请日：2019-03-29

Applicant: ISAGRO, S.P.A.

Inventor： Giuseppe D'ORAZIO ,  Serena CARIELLO ,  Marilena GUSMEROLI ,  Paolo BELLANDI ,  Chiara SARGIOTTO ,  Daniele BIANCHI ,  Riccardo LIGUORI

IPC: A01N43/78 ,  A01N43/82 ,  C07D277/56 ,  C07D285/12

Abstract: Fluoroalkenyl heterocyclic compounds having Formula (I) are described together with agronomic compositions containing said compounds having formula (I) and their use for the control of nematodes in agricultural crops.

公开(公告)号：US10738040B2

公开(公告)日：2020-08-11

申请号：US16190964

申请日：2018-11-14

Applicant: Proteostasis Therapeutics, Inc.

Inventor： Cecilia M. Bastos ,  Benito Munoz ,  Bradley Tait

IPC: C07D261/08 ,  C07D413/12 ,  C07F7/18 ,  C07D413/14 ,  C07D231/12 ,  C07D233/61 ,  C07D417/12 ,  C07D261/18 ,  C07D285/12 ,  A61K31/16 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/695 ,  A61K45/06 ,  C07C243/36

Abstract: The present disclosure features disclosed compounds which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound.

公开(公告)号：US10653681B2

公开(公告)日：2020-05-19

申请号：US16085505

申请日：2017-03-15

Applicant: Recurium IP Holdings, LLC

Inventor： Kevin Duane Bunker ,  Deborah Helen Slee ,  Chad Daniel Hopkins ,  Joseph Robert Pinchman ,  Mehmet Kahraman ,  Peter Qinhua Huang

IPC: A61K31/433 ,  A61K31/137 ,  A61K31/167 ,  A61K31/415 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  C07D213/38 ,  C07D271/113 ,  C07D233/12 ,  C07D285/08 ,  C07D277/42 ,  C07D239/42 ,  C07C233/07 ,  C07D263/48 ,  C07C233/15 ,  C07D231/12 ,  A61K31/165 ,  C07D277/32 ,  C07D285/12 ,  C07D277/28 ,  C07C211/29 ,  C07C233/13 ,  C07D277/40 ,  C07D213/73 ,  C07D285/125 ,  C07C233/25 ,  C07C211/52 ,  C07D285/135 ,  A61P29/00 ,  A61K31/136 ,  A61K9/00 ,  A61K45/06

Abstract: Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.

公开(公告)号：US10647688B2

公开(公告)日：2020-05-12

申请号：US15537549

申请日：2015-12-17

Applicant: GALDERMA RESEARCH & DEVELOPMENT

Inventor： Thibaud Portal

IPC: C07D277/30 ,  C07D231/12 ,  C07D261/08 ,  C07D271/06 ,  A61K8/49 ,  C07D233/64 ,  C07D333/24 ,  C07D207/337 ,  C07D263/32 ,  C07D271/10 ,  A61Q19/00 ,  C07D249/08 ,  C07D285/12 ,  A61Q5/00 ,  A61Q19/08 ,  A61Q7/00 ,  C07D271/107

Abstract: Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that modulate RARs.

公开(公告)号：US10577338B2

公开(公告)日：2020-03-03

申请号：US15914977

申请日：2018-03-07

Applicant: Citizen Finedevice Co., Ltd.

Inventor： William Thurmes ,  Christopher Gabriel

IPC: G02F1/1333 ,  C07D285/12 ,  C07D271/107 ,  C09K19/34 ,  C07D417/04 ,  C07D413/04 ,  C09K19/02 ,  G02F1/141

Abstract: New classes of thiadiazole and oxadiazole compounds for use in LC mixtures are disclosed. In an embodiment, the new classes of thiadiazoles and oxadiazoles comprise at least one phenyl ring attached to the heterocyclic ring, where no alkyl, alkenyl or alkynyl tails are attached to the phenyl ring, but one alkyl, alkenyl or alkynyl tail is attached to the other end of the molecule, and a fluoro or cyano group appears in the para position of the phenyl ring. These compounds are disclosed as being effective at inducing smectic A phases in liquid crystal mixtures, particularly in liquid crystal mixtures also possessing a smectic C phase, more particularly in materials possessing a chiral smectic C (ferroelectric) phase.

公开(公告)号：US10377695B2

公开(公告)日：2019-08-13

申请号：US15820194

申请日：2017-11-21

Applicant: Sanford Burnham Prebys Medical Research Institute

Inventor： Raveendra Panickar Dhanya ,  Douglas J. Sheffler ,  Nicholas D. P. Cosford

IPC: C07D333/24 ,  C07C65/40 ,  C07D257/04 ,  C07D271/06 ,  C07C259/10 ,  C07C311/51 ,  C07C235/46 ,  C07C235/54 ,  C07D213/79 ,  C07D213/80 ,  C07D239/26 ,  C07D241/12 ,  C07D271/07 ,  C07D285/08 ,  C07D295/108 ,  C07D213/50 ,  C07D213/68 ,  C07D213/70 ,  C07D307/42 ,  C07D307/68 ,  C07F7/02 ,  C07D213/64 ,  C07C49/84 ,  C07C59/90 ,  C07C69/92 ,  C07C251/48 ,  C07C255/56 ,  C07D213/55 ,  C07D241/24 ,  C07D277/24 ,  C07D285/12 ,  C07D295/16 ,  C07D295/26 ,  C07D307/54 ,  C07D311/16 ,  C07F5/02 ,  C07F5/04

Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

公开(公告)号：US20180370930A1

公开(公告)日：2018-12-27

申请号：US15996723

申请日：2018-06-04

Applicant: Agios Pharmaceuticals, Inc.

Inventor： Rene M. Lemieux ,  Janeta Popovici-Muller ,  Francesco G. Salituro ,  Jeffrey O. Saunders ,  Jeremy Travins ,  Shunqi Yan

IPC: C07D285/135 ,  C07D471/04 ,  C07D417/12 ,  C07D417/14 ,  C07D285/12

CPC classification number: C07D285/135 ,  C07D285/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

公开(公告)号：US10011574B2

公开(公告)日：2018-07-03

申请号：US14646239

申请日：2013-11-21

Applicant: AGIOS PHARMACEUTICALS, INC.

Inventor： Rene M. Lemieux ,  Janeta Popovici-Muller ,  Francesco G. Salituro ,  Jeffrey O. Saunders ,  Jeremy Travins ,  Shunqi Yan

IPC: C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D421/00 ,  C07D513/00 ,  C07D285/14 ,  C07D285/08 ,  A61K31/44 ,  A61K31/41 ,  C07D285/135 ,  C07D417/14 ,  C07D285/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D285/135 ,  C07D285/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

公开(公告)号：US20180016243A1

公开(公告)日：2018-01-18

申请号：US15550155

申请日：2016-02-12

Applicant: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE

Inventor： Andreas MEYERHANS ,  Miguel-Angel MARTINEZ DE LA SIERRA ,  Annalaura BRAI ,  Roberta FAZI ,  Cristina TINTORI ,  Maurizio BOTTA ,  Jose-Este ARAQUE ,  Javier MARTINEZ

IPC: C07D249/06 ,  A61K31/4192 ,  C07D405/12 ,  C07D401/12 ,  C07D401/04 ,  C07D285/12 ,  C07D271/10 ,  C07D271/06 ,  C07D261/08 ,  A61K45/06 ,  A61K31/7056 ,  A61K31/675 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/42 ,  C07F9/6518 ,  C07H15/18

CPC classification number: C07D249/06 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7056 ,  A61K45/06 ,  C07D249/04 ,  C07D257/04 ,  C07D261/08 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07F9/6518 ,  C07H15/18

Abstract: The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.