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公开(公告)号：US20230405488A1
公开(公告)日：2023-12-21
申请号：US18241405
申请日：2023-09-01
发明人： Kamalesh Sirkar
IPC分类号： B01D9/00 , C07C213/06 , C07C213/10 , B01D61/28 , B01D11/04 , C07D403/06 , B01D9/02
CPC分类号： B01D9/0059 , C07C213/06 , C07C213/10 , B01D61/28 , B01D11/0492 , C07D403/06 , B01D9/02 , B01D2009/0086
摘要： The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.
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公开(公告)号：US11633699B2
公开(公告)日：2023-04-25
申请号：US15502736
申请日：2015-08-05
申请人： OSAKA UNIVERSITY
发明人： Takashi Matsuzaki , Tetsuo Minamino , Ryo Araki
摘要： A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.
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公开(公告)号：US11413384B2
公开(公告)日：2022-08-16
申请号：US16762623
申请日：2018-12-10
申请人： GAMBRO LUNDIA AB
摘要： The present disclosure relates to capillary dialyzers for blood purification, in particular, capillary dialyzers suitable for home hemodialysis systems.
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公开(公告)号：US11383011B2
公开(公告)日：2022-07-12
申请号：US16200261
申请日：2018-11-26
申请人： GastroKlenz Inc.
发明人： Aly R. A. A. Elbadry
摘要： Devices, systems, and methods herein relate to performing dialysis to manage a chronic condition such as end-stage renal disease. These systems and methods may allow a patient to orally ingest a potable dialysate and excrete the dialysate via the urinary tract. In some variations, a method may include delivering a dialysate via the esophagus of a patient and draining the dialysate into a bladder of the patient. Delivering the dialysate may further comprise delivering the dialysate through the nasopharynx or oropharynx. Delivering the dialysate through the oropharynx may comprise the patient drinking the dialysate.
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公开(公告)号：US11040128B1
公开(公告)日：2021-06-22
申请号：US16752625
申请日：2020-01-25
申请人： Choon Kee Lee
发明人： Choon Kee Lee
摘要： To enhance diffusive mass transfer of small molecules and convective clearance of middle molecules, the present invention provides a cylindrical hemodialyzer which comprises a blood compartment having a packed bundle of hollow fibers in a doughnut configuration on a radial cross-section, and a motorized dialysate compartment comprising a dialysate inlet motor having an external stator and an internal rotor connected to an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers. The cylindrical hemodialyzer is configured to recirculate dialysate across the packed bundle of the hollow fibers propelled by the dialysate inlet motor. A dialysate outlet motor of the motorized dialysate compartment having an external stator and an internal rotor is configured to drain the dialysate and to control ultrafiltration by said cylindrical hemodialyzer.
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公开(公告)号：US10935474B1
公开(公告)日：2021-03-02
申请号：US16936650
申请日：2020-07-23
发明人： Iqbal Ahmed Moujdin
IPC分类号： G01N1/40 , B01D63/06 , B01D61/36 , B01D61/28 , B01D61/18 , B01D61/08 , B01D63/08 , B01D69/10 , B01D69/06 , B01D69/04
摘要： Provided herein is a membrane filter device comprising a cell top cover (A, Y) and a cell bottom cover (B, Z) covering the device, a flexible tube (35, E, F) whereas at the end of the tube, a nozzle jet (22) is also secured via conical reducer to produce upper Reynold's number and for distributing the feed fluid, within the hex hollow chamber (C, X) for storing and receiving feed fluid, a reducer chamber (C, R1, R2) for storing and receiving permeate filtrated fluid, a connector (32, 53, 56) connecting both feed chambers (A, Y, Z) and reducer chambers (A, Y, Z), a membrane assembly (M/F) comprising a layer of membrane (130) sandwiched by a pair of seal rings (P1, OR, P2) and a layer of support net (MS) for securing said membrane (M/F). Most of the joints are connected using threaded joint and flow pressure, therefore no external clamp, nuts or bolts is needed. The flexible tube and the cylindrical shape ensure uniform flow in chambers. The apparatus is therefore a user-friendly and steadfast membrane filter device.
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公开(公告)号：US10780399B2
公开(公告)日：2020-09-22
申请号：US15778460
申请日：2016-11-17
摘要： Membrane cell stack arrangement and method of manufacturing such a membrane cell stack arrangement. The arrangement has a housing (2) having a central axis, and a stack of membrane cells (4), each membrane cell (6) being arranged inside the housing (2) with a major surface (6a) of the membrane cell (6) oriented substantially perpendicular to the central axis. Each membrane cell (6) has a corner recess (12) between each two adjacent sides of at least four sides (10a-d). Sealing compartments (14) are provided by corner recesses (12) of adjacent membrane cells of the stack of membrane cells (4) in co-operation with a part of an inner surface (2a) of the housing (2).
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公开(公告)号：US20200268958A1
公开(公告)日：2020-08-27
申请号：US16666326
申请日：2019-10-28
摘要： Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge, where the one or more flowpaths including at least one of a blood flowpath for carrying a volume of blood to be treated in a dialyser and a dialysate flowpath, isolated from the blood flowpath, for delivering a flow of dialysate solution through the dialyser.
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公开(公告)号：US10729991B2
公开(公告)日：2020-08-04
申请号：US15580227
申请日：2016-06-20
摘要： A membrane contactor for degassing a gas-entrained liquid and to discharge gas-depleted liquid includes: a shell has two ends; a cap closes one shell end; a membrane extends between the shell ends and is enclosed within the shell; a first center tube discharges the gas-entrained liquid into the membrane; a second center tube discharges the gas-depleted liquid from the contactor; and one tube surrounds the other tube. The membrane may be a flat sheet membrane or a hollow fiber membrane. The cap has an in let in fluid communication with the first center tube and an outlet in fluid communication with the second center tube. A baffle may be located within the membrane between the shell ends.
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公开(公告)号：US10724986B2
公开(公告)日：2020-07-28
申请号：US14648497
申请日：2013-11-27
发明人： Afshin Izadian , Robert L. Bacallao
IPC分类号： G01N27/447 , B01D61/24 , B01D61/28 , G01N21/55 , G01N21/64
摘要： A system, device and apparatus for measuring electrolytes, where an electrical charge is applied to a measurement portion to draw ions from a liquid to a gel-solution via at least one electric field. The gel-solution containing the extracted ions is excited with light of a predetermined wavelength from an emitter. A receiver detects the illumination of the ions as a result of the excited gel-solution, and a processor converts the detected intensities of the illumination to a biologically useful value representing ionic concentration.
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